Physicochemical properties and membrane interactions of per(6-desoxy-6-halogenated) cyclodextrins was written by Debouzy, J.-C.;Crouzier, D.;Gadelle, A.. And the article was included in Annales Pharmaceutiques Francaises in 2007.Quality Control of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin This article mentions the following:
Per(6-iodo-6-desoxy) cyclodextrins are synthesis intermediates used in the design of the cation chelating per(3,6-anhydro) cyclodextrins. The modifications of the properties of these mols. resulting from the nature of the halogen substituent and also the number of osidic building blocks were investigated by varying both factors, using 1H and 31P-NMR and EPR spectroscopies. These nearly water insoluble mols. exhibits no complexing properties (for both ionic and apolar structures) but can be partially solubilized in micelles of detergent (SDS) and also in phospholipid vesicles. Dipolar connectivity (nOesy) NMR experiments show that they are embedded at the chain level of the micelles/vesicles, without any inclusion complex formation. Changing the number of glucose building blocks (6,7 or 8) or/and the nature of the halogen nuclei at the positions 6 strongly modify cyclodextrin affinities and membrane interactions. For instance the per(6-bromo-6-desoxy)-cyclomaltohexaose (ABR) and -cyclomalto-heptaose (BBR) exhibit a selective affinity for cobalt (apparent Ka of 2500 and 790 M-1, resp.). In terms of interactions with membranes, 濞?derivatives induce sterical hindrance at the phosphorus level while destructuring the chains. Other derivatives are located deeper and rigidify the most superficial part of the chain, suppressing the jump in membrane fluidity at transition temperature In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1Quality Control of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin).
Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary