Bromides-buliding-blocks

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols was written by Xia, Anjie;Qi, Xueyu;Mao, Xin;Wu, Xiaoai;Yang, Xin;Zhang, Rong;Xiang, Zhiyu;Lian, Zhong;Chen, Yingchun;Yang, Shengyong. And the article was included in Organic Letters in 2019.Application of 18791-79-2 This article mentions the following:

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcs. is reported. This reaction was highly efficient and tolerated various heteroaryl alcs., generating a carboxylic acid derivative and a neutral heteroaromatic compound Exptl. studies combined with d. functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Application of 18791-79-2).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 18791-79-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Molecular organization in the 6-bromo-6-deoxycyclodextrins, formation of molecular layers, and the first crystal structure of a selectivity perfunctionalized 閻?cyclodextrin was written by Nicolis, Ioannis;Coleman, Anthony W.;Charpin, Pierrette;Villain, Francoise;Zhang, Ping;Ling, Chang Chung;de Rango, Colette. And the article was included in Journal of the American Chemical Society in 1993.Synthetic Route of C42H63Br7O28 This article mentions the following:

6-Bromo-6-deoxycyclodextrins form stable monomol. at the air-H₂O interface, with mol. areas of 180, 220 and 260 闁?sup>2 for 濞?, 閻? and 缂?Br-CD. In the case of the heptakis-bromo-閻?CD compound 3 dimensional crystal structure was determined The heptakis-Br-閻?CD compound is monoclinic, space group P2₁, with a 15.714(3), b 15.917(6), c 30.102(4) 闁? 閻?90.55(2)闁? Z = 2. The structure is as a novel packing of dimeric 閻?cyclodextrin systems in a square arrangement. The layers are held together by Br-Br Van der Waals interactions giving rise to a quasi-continuous hydrophobic interface between the layers. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1Synthetic Route of C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Synthetic Route of C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Role of Molecular Weight in the Mechanical Properties and Charge Transport of Conjugated Polymers Containing Siloxane Side Chains was written by Huang, Gang;Wu, Ning;Wang, Xiaohong;Zhang, Guobing;Qiu, Longzhen. And the article was included in Macromolecular Rapid Communications in 2022.Electric Literature of C4H4BrNO2 This article mentions the following:

The mol. weight is a key factor affecting the properties of conjugated polymers. To determine the critical mol. weights of conjugated polymers modified with siloxane side chains, poly(diketo-pyrrolopyrrole-selenophene) (PTDPPSe-5Si) samples with mol. weights ranging from 20 to 350 kDa are synthesized. The critical mol. weight of the polymer is determined in the range of 60-100 kDa by testing the viscosity of the solution When the mol. weight of the 27-60 kDa polymers is below the critical mol. weight, they exhibit a high crystallinity and low ductility. When the mol. weight of the 100 kDa polymer reaches the critical mol. weight, the crystallinity decreases, and the ductility increases. As the mol. weight increases, the polymer film also gradually changes from brittle to ductile. Furthermore, when the mol. weight of the 315 kDa polymer is much higher than the critical mol. weight, the film exhibits a significant ductility, which results in the polymer films showing no pronounced cracks after high-percentage stretching. Addnl., due to the oriented alignment of the mol. chains caused by stretching, the carrier mobility in the parallel direction becomes 2.14-fold of the initial film. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Electric Literature of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 was written by Baqi, Younis;Pillaiyar, Thanigaimalai;Abdelrahman, Aliaa;Kaufmann, Olesja;Alshaibani, Samer;Rafehi, Muhammad;Ghasimi, Saman;Akkari, Rhalid;Ritter, Kirsten;Simon, Katharina;Spinrath, Andreas;Kostenis, Evi;Zhao, Qiang;Kose, Meryem;Namasivayam, Vigneshwaran;Muller, Christa E.. And the article was included in Journal of Medicinal Chemistry in 2018.Formula: C6H5BrClN This article mentions the following:

The orphan receptor GPR17 may be a novel drug target for inflammatory diseases. 3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL29,951, 1) was previously identified as a moderately potent GPR17 agonist. In the present study, we investigated the structure-activity relationships (SARs) of 1. Substitution of the indole 1-, 5-, or 7-position was detrimental. Only small substituents were tolerated in the 4-position while the 6-position accommodated large lipophilic residues. Among the most potent compounds were 3-(2-carboxyethyl)-1H-indole-2-carboxylic acid derivatives containing the following substituents: 6-phenoxy (26, PSB-1737, EC₅₀ 270 nM), 4-fluoro-6-bromo (33, PSB-18422, EC₅₀ 27.9 nM), 4-fluoro-6-iodo (35, PSB-18484, EC₅₀ 32.1 nM), and 4-chloro-6-hexyloxy (43, PSB-1767, EC₅₀ 67.0 nM). (3-(2-Carboxyethyl)-6-hexyloxy-1H-indole-2-carboxylic acid (39, PSB-17183, EC₅₀ 115 nM) behaved as a partial agonist. Selected potent compounds tested at human P2Y receptor subtypes showed high selectivity for GPR17. Docking into a homol. model of the human GPR17 and mol. dynamic simulation studies rationalized the observed SARs. In the experiment, the researchers used many compounds, for example, 3-Bromo-5-chlorophenylamine (cas: 96558-78-0Formula: C6H5BrClN).

3-Bromo-5-chlorophenylamine (cas: 96558-78-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon闁艰京鐗梤omine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Formula: C6H5BrClN

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators: An Opportunity for Treating Multiple Sclerosis was written by Weng, Qinjie;Che, Jinxin;Zhang, Zhikang;Zheng, Jiahuan;Zhan, Wenhu;Lin, Sendong;Tian, Tian;Wang, Jincheng;Gai, Renhua;Hu, Yongzhou;Yang, Bo;He, Qiaojun;Dong, Xiaowu. And the article was included in Journal of Medicinal Chemistry in 2019.Reference of 179232-29-2 This article mentions the following:

Multiple sclerosis (MS) is a disease of the autoimmune-mediated disorder in the central nervous system, for which no effective therapeutic agent is currently available. The regulation of macrophage polarization toward M2 is a general benefit for treating MS. The gene biomarker-based phenotypic screening approach was developed, and 3,4-disubstituted piperidine derivative S-28 was identified as a lead compound modulating macrophage M2 polarization. Further SAR studies resulted in the discovery of the most potent modulator D11 that showed good oral bioavailability and significant in vivo therapeutic effects. Mechanistic studies demonstrated that the M2 polarization macrophages modulated by D11 mainly functioned through inhibiting the proliferation of T-cells and activating the phosphorylation of Stat3 and Akt. Therefore, the gene biomarker-based phenotypic screening was demonstrated as a promising tool for the discovery of novel macrophage M2 polarization modulators. Compound D11 may serve as a promising starting point for the development of therapeutics to treat MS. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Reference of 179232-29-2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Reference of 179232-29-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Polyamide-Scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal was written by Lo, Anthony T. S.;Salam, Noeris K.;Hibbs, David E.;Rutledge, Peter J.;Todd, Matthew H.. And the article was included in PLoS One in 2011.HPLC of Formula: 1196-90-3 This article mentions the following:

Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed “click” reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodn. profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3HPLC of Formula: 1196-90-3).

Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.HPLC of Formula: 1196-90-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Double C(sp³)-H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles was written by Mori, Keiji;Kurihara, Kazuki;Yabe, Shinnosuke;Yamanaka, Masahiro;Akiyama, Takahiko. And the article was included in Journal of the American Chemical Society in 2014.Reference of 61150-57-0 This article mentions the following:

Described herein are two novel types of double C(sp³)-H bond functionalizations triggered by a sequential hydride shift/cyclization process: (1) construction of a bicyclo[3.2.2]nonane skeleton, e.g., I, by a [1,6]- and [1,5]-hydride shift sequence and (2) sequential [1,4]- and [1,5]-hydride shift mediated construction of a linear tricyclic skeleton, e.g., II. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Reference of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases was written by Thomson, Andrew;O’Connor, Sean;Knuckley, Bryan;Causey, Corey P.. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Related Products of 954-81-4 This article mentions the following:

Agmatine deiminases (AgDs) belong to a family of enzymes known as guanidinium group modifying enzymes (GMEs). Many pathogenic bacteria encode an AgD that participates in the catabolism of agmatine (decarboxylated arginine). This catabolism may confer a competitive survival advantage, by virtue of energy production and increased acid tolerance, making this sub-family of enzymes a potential therapeutic target that warrants further study. Herein we report the development of an activity-based protein profiling (ABPP) probe that selectively targets the AgD from Streptococcus mutans. Due to the selectivity and covalent nature of the modification, this probe could prove to be a valuable tool for the study of other AgD family members. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Related Products of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon闁艰京鐗梤omine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Potent and Highly Selective Inhibitor of Human 濞?1,3-Fucosyltransferase via Click Chemistry was written by Lee, Lac V.;Mitchell, Michael L.;Huang, Shih-Jung;Fokin, Valery V.;Sharpless, K. Barry;Wong, Chi-Huey. And the article was included in Journal of the American Chemical Society in 2003.Name: N-(5-Bromopentyl)phthalimide This article mentions the following:

Potent inhibitors of fucosyltransferases, and glycosyltransferases in general, have been elusive due to the inherent barriers surrounding the family of glycosyl transfer reactions. The problems of weak substrate affinity and low catalytic proficiency of fucosyltransferase was offset by recruiting addnl. binding features, in this case hydrophobic interactions, to produce a high affinity inhibitor, 24, with K_i = 62 nM. The mol. was identified from a GDP-triazole library of 85 compounds, which was produced by the Cu(I)-catalyzed [2+3] cycloaddition reaction between azide and acetylene reactants, followed by in situ screening without product isolation. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Name: N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Name: N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of (5’S)-5′-C-alkyl-2′-deoxynucleosides was written by Trafelet, Huldreich;Stulz, Eugen;Leumann, Christian. And the article was included in Helvetica Chimica Acta in 2001.Recommanded Product: Isopentyltriphenylphosphonium bromide This article mentions the following:

We describe the synthesis of (5’S)-5′-C-butylthymidine, of the (5’S)-5′-C-butyl- and the (5’S)-5′-C-isopentyl derivatives of 2′-deoxy-5-methylcytidine, as well as of the corresponding cyanoethyl phosphoramidites resp. Starting from thymidin-5′-al, the alkyl chain at C(5′) is introduced via Wittig chem. to selectively yield the (Z)-olefin derivatives The secondary OH function at C(5′) is then introduced by epoxidation followed by regioselective reduction of the epoxy derivatives 4a and 4b with diisobutylaluminium hydride. In the latter step, a kinetic resolution of the diastereoisomer mixture occurs, yielding the alkylated nucleoside, with (5’S)-configuration in high diastereoisomer purity (de = 94%). The corresponding 2′-deoxy-5-methylcytidine derivatives are obtained from the protected 5′-alkylated thymidine derivatives via known base interconversion processes in excellent yields. Application of the same strategy to the purine nucleoside 2′-deoxyadenine to obtain 5′-C-butyl-2′-deoxyadenosine 25 proved to be difficult due to the sensitivity of the purine base to hydride-based reducing agents. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Recommanded Product: Isopentyltriphenylphosphonium bromide).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: Isopentyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary