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Reference of 4549-33-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4549-33-1 name is 1,9-Dibromononane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of mixture of 3,7-bis(tert-butoxycarbonylamino)-2,8-dimethyl-5- phenylphenazin-5-ium chloride and 3,7-bis(tert-butoxycarbonylamino)-2,6-dimethyl-5- phenylphenazin-5-ium chloride (500 mg, 0.909 mmol) in 10 mL of DMF was added cesium carbonate (738 mg, 2.27 mmol) and stirred at RT for 15 min. The reaction mixture was cooled to 0C and 1,9-dibromononane (156 mg, 0.545 mmol, diluted with 1 mL of DMF) was added dropwise. The reaction mixture was stirred at RT for 12 h. The reaction was monitored by TLC and LCMS. After completion of reaction, the mixture was diluted with ice-cold water and filtered. The solid residue obtained after filtration was dissolved in diethyl ether (200 mL) and washed with brine solution (3×50 mL). The ether layer was dried over anhydrous sodium sulfate, concentrated under reduced pressure to afford the crude product which was purified by column chromatography (neutral alumina, eluent 0-20% EtOAc in hexane) to afford the desired product (mixture of 2 products of same mass) as a dark brown solid (400 mg).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,9-Dibromononane, and friends who are interested can also refer to it.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; RAI, Roopa; PHAM, Son Minh; HART, Barry Patrick; (437 pag.)WO2017/19832; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 103273-01-4 as follows. name: 2-Bromo-4-(tert-butyl)aniline

2-Bromo-4-tert-butyl-5-nitro-phenylamine 2-Bromo-4-tert-butyl-phenylamine (160 g, 0.71 mol) was added dropwise to H2SO4 (410 mL) at room temperature to yield a clear solution. This clear solution was then cooled down to -5 to -10 C. A solution of KNO3 (83 g, 0.82 mol) in H2SO4 (410 mL) was added dropwise while the temperature was maintained between -5 to -10 C. Upon completion, the reaction mixture was poured into ice/water and extracted with EtOAc. The combined organic layers were washed with 5% Na2CO3 and brine, dried over Na2SO4 and concentrated. The residue was purified by a column chromatography (ethyl acetate/petroleum ether 1:10) to give 2-bromo-4-tert-butyl-5-nitro-phenylamine as a yellow solid (150 g, 78%).

According to the analysis of related databases, 103273-01-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Vertex Pharmaceuticals Incorported; US2011/98311; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, This compound has unique chemical properties. The synthetic route is as follows., Formula: C4H10Br3N

PREPARATION 5 A mixture of 6-amino-8-methyl-3,4-dihydro-2(1H)-quinolinone (19.4 g), bis(2-bromoethyl)amine hydrobromide (41 g) and methanol (140 ml) was stirred for 13 hours at 64 C. After cooling, sodium carbonate (5.83 g) was added thereto and the mixture was stirred for 9 hours at 70 C. After cooling, the resulting precipitate was collected by filtration and the residue was washed with methanol to give 3,4-dihydro-8-methyl-6-(1-piperazinyl)-2(1H)-quinolinone hydrobromide (21.6 g). mp: >250 C. IR (Nujol): 1680, 1595 cm-1

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 43204-63-3.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4988698; (1991); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Safety of L-Theanine, 3081-61-6, Name is L-Theanine, molecular formula is C7H14N2O3, belongs to bromides-buliding-blocks compound. In a document, author is Rahim, Md. Abdur, introduce the new discover.

Influence of Polyol/Salt Additives on the Drug-Mediated Phase Separation and Thermodynamic Properties of Triton X-100

Herein, we investigated the impact of different additives [polyols (glucose, galactose, and maltose)/electrolytes (KCl, K2SO4, and K3PO4 center dot 7H(2)O)] on the interaction between quinolone antibiotic drug, ciprofloxacin hydrochloride (CFH), and Triton X-100 (TX-100) via the cloud point (CP) measurement technique. The magnitudes of CP of TX-100 were observed to be reduced with the enlargement of TX-100 concentration. The CP values show U-shaped variation as a function of CFH concentration in the aqueous medium. The CP values dwindle in the existence of electrolyte, which continues with the rise of electrolyte concentration. The observed CP values in the electrolyte medium follow the order CPK3PO4.7H2O > CPK2SO4 > CPKCl. The CP values reduced in the presence of organic additives (polyols) also. The executed magnitudes of Gibbs free energy (Delta G(c)degrees) of clouding were positive in all cases, signifying the nonspontaneous phenomenon. The Delta G(c)degrees values reduce with TX-100 concentration. The values of enthalpy of clouding (Delta H-c degrees) and entropy of clouding (Delta S-c degrees), as well as different transfer properties of thermodynamic parameters, were estimated and interpreted in detail. Excellent entropy-enthalpy compensation was observed in all cases.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 3081-61-6. Safety of L-Theanine.