Category: 957061-13-1

Dunn, Derek published the artcileFrom an atypical wake-promoting agent to potent histamine-3 receptor inverse agonists, HPLC of Formula: 957061-13-1, the publication is Chemical Biology & Drug Design (2013), 81(3), 433-435, database is CAplus and MEDLINE.

Utilizing atypical wake-promoting agent modafinil (inactive in both rH₃ and hH₃ binding assays) as a launching pad, a series of sulfinyl- and sulfone-derived H₃ receptor inverse agonists were developed. A potent member of the series displayed excellent selectivity against related family members (H₁, H₂, and H₄ receptors).

Chemical Biology & Drug Design published new progress about 957061-13-1. 957061-13-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronate Esters, name is 2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H22BBrO3, HPLC of Formula: 957061-13-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Xiaobo published the artcileCrowding-Induced Unconventional Phase Behaviors in Dendritic Rodlike Molecules via Side-Chain Engineering, HPLC of Formula: 957061-13-1, the publication is ACS Macro Letters (2021), 10(7), 844-850, database is CAplus and MEDLINE.

Dendritic mols. with a fanlike or conelike conformation are common mol. building blocks to construct supramol. columnar or spherical phases. Although it is well-accepted that the preferred mol. conformation of dendritic mols. dictates their packing schemes, manipulation of this crucial parameter usually requires significant changes in mol. structures and tedious synthetic efforts. Herein, we report a simple yet highly efficient strategy to tune the mol. conformation of dendritic rodlike mols. by adjusting the length of alkyl side chains tethered to the rods. Strikingly, tiny chem. structure differences can largely change the “crowding” near the branching point to induce the “fanlike to conelike” conformational transitions and thus result in the formation of diverse supramol. structures, including the columnar phase, double gyroid phase, and the unconventional Frank-Kasper σ and A15 phases. Our study provides a practical platform for further investigation of unconventional structure formation and phase transitions in soft matter.

ACS Macro Letters published new progress about 957061-13-1. 957061-13-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronate Esters, name is 2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H22BBrO3, HPLC of Formula: 957061-13-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lin, Zhiwei published the artcileTopologically Directed Assemblies of Semiconducting Sphere-Rod Conjugates, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (2017), 139(51), 18616-18622, database is CAplus and MEDLINE.

Spontaneous organizations of designed elements with explicit shape and symmetry are essential for developing useful structures and materials. We report the topol. directed assemblies of four categories (a total of 24) of sphere-rod conjugates, composed of a sphere-like fullerene (C₆₀) derivative and a rod-like oligofluorene(s) (OF), both of which are promising organic semiconductor materials. Although the packing of either spheres or rods has been well-studied, conjugates having both shapes substantially enrich resultant assembled structures. Mandated by their shapes and topologies, directed assemblies of these conjugates result not only in diverse unconventional semiconducting supramol. lattices with controlled domain sizes but also in tunable charge transport properties of the resulting structures. These results demonstrate the importance of persistent mol. topol. on hierarchically assembled structures and their final properties.

Journal of the American Chemical Society published new progress about 957061-13-1. 957061-13-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronate Esters, name is 2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H22BBrO3, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Willmann, Michael published the artcileRadiosynthesis and Biological Evaluation of [¹⁸F]R91150, a Selective 5-HT_2A Receptor Antagonist for PET-Imaging, HPLC of Formula: 957061-13-1, the publication is ACS Medicinal Chemistry Letters (2021), 12(5), 738-744, database is CAplus and MEDLINE.

Serotonergic 5-HT_2A receptors in cortical and forebrain regions are an important substrate for the neuromodulatory actions of serotonin in the brain. They have been implicated in the etiol. of many neuropsychiatric disorders and serve as a target for antipsychotic, antidepressant, and anxiolytic drugs. Positron emission tomog. imaging using suitable radioligands can be applied for in vivo quantification of receptor densities and receptor occupancy for therapy evaluation. Recently, the radiosynthesis of the selective 5-HT_2AR antagonist [¹⁸F]R91150 was reported. However, the six-step radiosynthesis is cumbersome and time-consuming with low radiochem. yields (RCYs) of <5%. In this work, [¹⁸F]R91150 was prepared using late-stage Cu-mediated radiofluorination to simplify its synthesis. The detailed protocol enabled us to obtain RCYs of 14 ± 1%, and the total synthesis time was reduced to 60 min. In addition, autoradiog. studies with [¹⁸F]R91150 in rat brain slices revealed the typical uptake pattern of 5-HT_2A receptor ligands.

ACS Medicinal Chemistry Letters published new progress about 957061-13-1. 957061-13-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronate Esters, name is 2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C18H15N3O3, HPLC of Formula: 957061-13-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary