Category: 955959-84-9

955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 955959-84-9

General procedure: 26.8 g (100 mmol) of 8H-quino[4,3,2-kl]acridine [111180-95-5], 35.6 g (100 mmol), 5?-iodo-1,1:3?,1?-terphenyl [87666-86-2], 27.6 mg / g (200 mmol) of potassium carbonate, 28.4 g g (200 mmol) of sodium sulfate, copper powder of 1.3gg (20mmol), Glass Beads (Diameter: 3 mm) And a mixture of 300 ml of nitrobenzene is heated under reflux while stirring well for 16 hours under reflux. After cooling down, Add 1000 ml of methanol, Suction and filter the solid, Wash 3 times with 300 ml of methanol each time. This solid is extracted from 1000 ml of water by stirring with high temperature. After suction filtration, Wash every 2 times with 200 ml of hot water each time. After washing 3 times with 200 ml of methanol each time, Dry under reduced pressure. The resulting crude product is o-xylene (initial dose: 250 ml) 5 times a high temperature extract, Next, 2 times fractional sublimation (p is about 10-5 mbar, T about 310 C). Yield: 28.3 mug g (57 mmol), 57%; Purity: 99.99% by HPLC.

Statistics shows that 955959-84-9 is playing an increasingly important role. we look forward to future research findings about 4-(4-Bromophenyl)dibenzo[b,d]furan.

Reference:
Patent; Merck Patent GMBH; Syu Toe-ssel-pil-rip; Pa Reu-ham-a-mi-reu; Yo Syu-ten-do-mi-ni-keu; Ru De-mang-o-rel-ri; Geu Ro-sseu-man-to-bi-a-seu; Keu Roe-beo-yo-na-seu; (57 pag.)KR2019/86028; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 955959-84-9

To a 250 mL round bottom flask was added 4-phenylaniline (1.80 g, 10.64 mmol), D1 (3.78 g, 11.70 mmol), Tris (dibenzylideneacetone) dipalladium (0) (0.15 g, -Bis (diphenylphosphino) -1,1′-binaphthalene (BINAP) (0.20 g, 0.32 mmol) and sodium tert-butoxide (1.43 g, 14.89 mmol) were dissolved in toluene (100 mL) After completion of the reaction, the reaction mixture was stirred for 24 hours. Toluene was removed, and the residue was extracted with dichloromethane and water. The residue was subjected to vacuum distillation. The silica gel column was distilled under reduced pressure to obtain Compound D2 (3.05 g, 7.41 mmol).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 955959-84-9.

Reference:
Patent; LG Display Co., Ltd.; Lee Seung-jae; Pin Jong-gwan; Seo Bo-min; Ryu Yeong-ju; (41 pag.)KR2018/60582; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

955959-84-9, A common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, molecular formula is C18H11BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 1) d.) 500 mg (1.55 mmol) 4-(4-bromophenyl)dibenzofuran, 760 mg (1 .70 mmol) 2-(9H-carbazol-3- yl)-6-phenyl-benzimidazolo[1 ,2-a]benzimidazole, 990 mg (4.64 mmol) potassium phosphate tribasic, 60 mg (0.31 mmol) copper iodide in 10 ml dioxane are stirred under nitrogen at 100¡ãC. 1.24 g (36.1 mmol) cis, trans 1 ,2-diaminocyclohexane are added. The reaction mixture is stirred for 48 h. The reaction mixture is poured in methanol. The product is filtered off and is washed with water, methanol 10 percent tatraic acid. Column chromatography on silica gel with chloroform gives the product. Yield 690 mg (65 percent) MS (APCI(pos), m/z): 691 (M+1).

The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SCHAeFER, Thomas; KAWAMURA, Masahiro; NAGASHIMA, Hideaki; (314 pag.)WO2017/56052; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding some certain compound to certain chemical reactions, such as: 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 955959-84-9. 955959-84-9

474 mg (1.00 mmol) of Intermediate (F), 388 mg (1.20 mmol) of 4-(4-bromophenyl)dibenzo[b,d]furan, 91.6 mg(0.100 mmol) of Pd2(dba)3, 100 mL (50percent in toluene, 0.200 mmol) of tri-tert-butylphosphine (ttbp), and 192 mg (2.00mmol) of sodium tert-butoxide were added to 10 mL of xylene, and then, the mixture was heated at a temperature of145¡ãC while stirring. When the reaction stopped, the reaction product was cooled to room temperature and then subjectedto silica gel to perform filtering under a reduced pressure, and the filtration solution was concentrated under a reducedpressure. The product was subjected to silica gel column chromatography (ethylacetate: n-hexane = 1: 4 volume tovolume). The product was refined by recrystallization using toluene/methanol to obtain 537 mg (yield of 75percent) of Compound3 as a target compound. LC-Mass (calculated: 716.26 g/mol, found: M+1 = 717 g/mol)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-(4-Bromophenyl)dibenzo[b,d]furan.

Reference:
Patent; Samsung Electronics Co., Ltd; Samsung SDI Co., Ltd.; Jung, Yongsik; Son, Jhunmo; Lee, Seungjae; Kim, Youngkwon; Kim, Hyungsun; Chung, Yeonsook; EP2878599; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary