Category: 955959-84-9

955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C18H11BrO

475 mg (1.00 mmol) of Intermediate (B), 388 mg (1.20 mmol) of 4-(4-bromophenyl)dibenzo[b,d]furan, 91.6 mg(0.100 mmol) of Pd2(dba)3, 100 mL (50percent in toluene, 0.200 mmol) of tri-tert-butylphosphine (ttbp), and 192 mg (2.00mmol) of sodium tert-butoxide were added to 10 mL of xylene, and then, the mixture was heated at a temperature of145¡ãC while stirring. When the reaction stopped, the reaction product was cooled to room temperature and then subjectedto silica gel to perform filtering under a reduced pressure, and the filtration solution was concentrated under a reducedpressure. The product was subjected to silica gel column chromatography (ethylacetate: n-hexane = 1: 4 volume tovolume). The product was refined by recrystallization using toluene/methanol to obtain 465 mg (yield of 65percent) of Compound1 as a target compound. LC-Mass (calculated: 715.26 g/mol, found: M+1 = 716 g/mol)

The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung Electronics Co., Ltd; Samsung SDI Co., Ltd.; Jung, Yongsik; Son, Jhunmo; Lee, Seungjae; Kim, Youngkwon; Kim, Hyungsun; Chung, Yeonsook; EP2878599; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, A new synthetic method of this compound is introduced below., Safety of 4-(4-Bromophenyl)dibenzo[b,d]furan

In a dry 2L three-necked flask, 26.5 g (81 mmol, 1.1 eq.) of Intermediate-1 obtained in Reaction Formula 1 and 23.8 g (73.6 mmol, 1.0 eq.) of 4-(4-bromophenyl)-dibenzofuran were added. Then add dried and degassed 1000 ml of toluene as a solvent. Pass nitrogen for 15 minutes. Then add 10.6 g (110.4 mmol, 1.5 eq.) sodium tert-butoxide, A toluene solution (m/v, 10percent) of 1.3 g (2percent mol) of catalyst Pd2(dba)3 and 6.0 ml (4percent mol) P(t-bu)3. The temperature was raised to 90¡ãC and the reaction was carried out for 1.5 hours. After the reaction was completed, the mixture was cooled to room temperature, adsorbed on activated charcoal, suction filtered, and the solvent was removed by spin-drying. Recrystallization from toluene and ethanol gave 30.6 g of Intermediate 2 in 73percent yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nanjing Gao Guang Semiconductor Materials Co., Ltd.; Jin Zhenyu; Qian Chao; Wang Xiaowei; Dai Peipei; (37 pag.)CN108101896; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 955959-84-9, These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 250 mL round bottom flask was added D1 (1.80 g, 10.64 mmol),G3 (3.78 g, 11.70 mmol), Tris (dibenzylideneacetone) dipalladium (0) (0.15 g, 0.16 mmol),(BINAP) (0.20 g, 0.32 mmol) and sodium tert-butoxide (1.43 g, 14.89 mmol) were added to a solution of (¡À) -2,2′-Bis (diphenylphosphino) -1,1′- binaphthaleneAfter dissolving in toluene (100 mL)After stirring for 24 hours at 100 C in a bath, when the reaction is completeToluene was removed, and the residue was extracted with dichloromethane and water. The residue was subjected to vacuum distillation. The residue was subjected to silica gel column, and the solvent was distilled off under reduced pressure to obtain Compound G4 (3.05 g, 7.41 mmol).

Statistics shows that 4-(4-Bromophenyl)dibenzo[b,d]furan is playing an increasingly important role. we look forward to future research findings about 955959-84-9.

Reference:
Patent; LG Display Co., Ltd.; Pin Jong-gwan; Lee Na-yeon; Seo Bo-min; Ryu Yeong-ju; (43 pag.)KR2018/61825; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 955959-84-9, These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

0.21 g of palladium(II) acetate, xylene (20 mL), and 0.76 g of tri-tert-butylphosphine are added,Stirred at 60 ¡ãC for 30 minutes.The above solution was added to a flask heated to 60¡ãC under nitrogen to give the above compound 2 (7,9-Dihydrobenzo[4,5]furo[2,3-g]benzofurano[2′,3′:4,5]indolo[2,3-b]carbazole 7.4g), 4-(4-Bromophenyl)dibenzo[b,d]furan (13.2 g) and sodium tert-butoxide 5.2 g (54 mmol) were added to the above solution together with xylene (180 mL). Then, it heated up at 130 ¡ãC, and it heat-stirred for 6 hours. After cooling to room temperature, 200 mL of water was added. After the organic layer was extracted with chloroform, the organic layer was dried over MgSO 4 , the solvent was removed, and silica gel column chromatography was performed to give Compound A-9 (7.4 g, 47percent).

The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Co., Ltd. LG Chemical; Hong Wanshao; He Zaicheng; Xu Shangde; Jin Zhengfan; Li Zaizhuo; Jin Yuanhuan; (73 pag.)CN108017654; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 955959-84-9,Some common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, molecular formula is C18H11BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the 250 mE rounded-bottom flask, the compound Al (1.80 g, 10.64 mmol), the compound F2 (3.78 g, 11.70 mmol), tris(dibenzylideneacetone) dipalladium(0) (0.15 g, 0.16 mmol), (¡À)-2,2?-bis(diphenylphosphino)-l , 1 ?-binaphthalene(I3INAP) (0.20 g, 0.32 mmol) and sodium tertbutoxide(l.43 g, 14.89 mmol) were dissolved in toluene (100 mE) and stirred in the bath of the temperature of 100 C. for 24 hrs. After the completion of the reaction, toluene was removed, and the resultant was extracted and distilled under the reduced pressure using dichioromethane and water. After the silica gel colunm, the solvent was distilled under the reduced pressure such that the compound F3 was obtained. (3.05 g, 7.41 mmol)

The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG DISPLAY CO., LTD.; LEE, Seung-Jae; BIN, Jong-Kwan; SEO, Bo-Min; CHOI, Hye-Ock; (62 pag.)US2018/97184; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 955959-84-9

In the argon atmosphere, weighing intermediate respectively (1-1) 3.2g (10.0mmol), intermediate (A-2-1) 5.8g (10.0mmol), Pd2(dba)30.14g (0.15mmol), P (tBu)3HBF40.087g (0.3mmol), tertiary butyl alcohol sodium 1.9g (20.0mmol), adding anhydrous xylene 50 ml, heating reflux for 8 hours.After the reaction, the reaction mixture is cooled to 50 ¡ãC, filtered through diatomaceous earth/silica gel, concentrated filtrate. The obtained concentrated residue after being refined with silica gel column chromatography, using toluene recrystallization, get 2.9g of the white crystal (yield 35percent).

The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; Jiateng, Pengxi; Sounei, Shenhao; Zhou, Qiaozhenghe; Tengshan, Gaoguang; (107 pag.)CN105431417; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

955959-84-9, These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 250 ml three-necked flask, 0.012 mol of the raw material 1-1, 0.010 mol of the raw material II-1, and 150 ml of toluene were added and stirred under a nitrogen atmosphere.Then add 5¡Á10-5 mol Pd2(dba)3, 5¡Á10-5 mol P(t-Bu)3, 0.03 mol sodium tert-butoxide, heated to 105 C, refluxed for 24 hours, sampling the plate, showing no bromine remaining, the reaction is complete; naturally cooled to room temperature, filtered, and the filtrate is rotary evaporated to no fraction, and passed through a neutral silica gel column to obtain the desired product intermediate B-1; HPLC purity 99.93%, yield 77.3%;

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 955959-84-9.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Tang Dandan; Li Chong; Zhang Zhaochao; Ye Zhonghua; (71 pag.)CN109761967; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 955959-84-9, 955959-84-9

6.3 g (15.4 mmol) of N-phenyl-3,3-bicarbazole, 5.0 g (15.4 mmol) of 4-(4-bromophenyl)dibenzo[b,d]furan, 3.0 g (30.7 mmol) of sodium t-butoxide, 0.9 g (1.5 mmol) of tris(dibenzylideneacetone)dipalladium, and 1.2 mL of tri t-butylphosphine (50% in toluene) were mixed with 100 mL of xylene in a 250 mL round flask, and the mixture was heated and refluxed under a nitrogen flow for 15 hours. The obtained mixture was added to 300 mL of methanol, and a solid crystallized therein was filtered, dissolved in dichlorobenzene, filtered with silica gel/Celite, and after removing an appropriate amount of an organic solvent, recrystallized with methanol to obtain Compound B-78 (7.3 g, a yield of 73%). (0183) calcd. C48H30N2O: C, 88.59; H, 4.65; N, 4.30; O, 2.46. found: C, 88.56; H, 4.62; N, 4.20; 0, 2.43.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(4-Bromophenyl)dibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SAMSUNG SDI CO., LTD.; JUNG, Ho Kuk; LUI, Jinhyun; KIM, Dong-Yeong; JANG, Kipo; HUH, Dal-Ho; YU, Eun Sun; JUNG, Sung-Hyun; (75 pag.)US2019/280211; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

955959-84-9, The chemical industry reduces the impact on the environment during synthesis 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.

The specific synthetic route of the compound is now provided:250ml of four bottles, in the atmosphere of nitrogen,0.01 mol of 2- (4-bromophenyl) -dibenzofuran, 0.025 mol of acridine,0.03 mol sodium tert-butoxide, 1 x 10-4 mol Pd2 (dba) 3, 1 x 10-4 mol tri-tert-butylphosphine,150ml toluene, heated reflux 24 hours, sampling point plate, the reaction is complete, natural cooling, filtration,The filtrate was steamed and passed through a silica gel column to give the target product with 99.0percent purity and 69.00percent yield.

The chemical industry reduces the impact on the environment during synthesis 4-(4-Bromophenyl)dibenzo[b,d]furan. I believe this compound will play a more active role in future production and life.

Reference:
Patent; CECEP Wanrun Co., Ltd.; Li Chong; Xu Kai; Zhang Zhaochao; (37 pag.)CN107056758; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, This compound has unique chemical properties. The synthetic route is as follows., 955959-84-9

Under nitrogen environment (N2 purging), Compound H was dissolved in tetrahydrofuran and then 1.2 equivalents of n-butyllithium were added slowly at -78 C. The reaction mixture was stirred at -78 C for 1 hour, and then the reaction mixture was stirred at room temperature for 2 hours.Again the reaction mixture was cooled to -78 trimethyl borate was added and slowly raised to room temperature and stirred for 2 hours. HCl (5.0%) diluted in the reaction mixture was slowly poured and stirred for 1 hour while maintaining the pH between 5 and 6, and then extracted with dichloromethane. The organic layer was extracted with brine and DI water, and then water was removed with MgSO 4. After removing the organic solvent, compound I was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; LG Display Co., Ltd.; Yoon Gyeong-jin; Noh Hyo-jin; (33 pag.)KR2019/63923; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary