Category: 944718-31-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 944718-31-4, name is 5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole

Methyl-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-7H-benzo[i/][l,2,3]triazoleTo a solution of 5-bromo-l-methyl-iH-benzo[Patent; BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.; WO2012/119046; (2012); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 944718-31-4 as follows. Recommanded Product: 944718-31-4

5-bromo-1-methyl-1H-benzo[d][1,2,3]triazole (302.3 mg, 1.426 mmol),Benzophenone imine (342.5 mg, 1.890 mmol),t-BuONa (274.2 mg, 2.853 mmol),BINAP (87.8mg, 0.141mmol)And Pd2 (dba) 3 (131.4 mg, 0.1435 mmol)Dissolved in 1,4-dioxane (10 mL).The reaction mixture is at 100 ° C,Stir for 6 hours in a nitrogen atmosphere.After the reaction was completed, it was concentrated under reduced pressure.The residue was diluted with water (50 mL).The resulting mixture was taken with DCM and MeOHThe mixed solvent (10/1 (v/v), 80 mL × 3) was extracted.The combined organic phases were dried over anhydrous Na 2 SO 4 and filtered.The filtrate was concentrated under reduced vacuo afforded title crystallThe crude product was used directly in the next step without further purification.

According to the analysis of related databases, 944718-31-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 944718-31-4, name is 5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole

A mixture of 5-bromo-l-methyl-liT-benzo[7][l,2,3]triazole (302.3 mg, 1.426 mmol), diphenylmethanimine (342.5 mg, 1.890 mmol), t-BuONa (274.2 mg, 2.853 mmol), BINAP (87.8 mg, 0.141 mmol) and Pd2(dba)3 (131.4 mg, 0.1435 mmol) in l,4-dioxane (10 mL) was heated to 100 °C and stirred for 6 hours under N2 atmosphere and concentrated in vacuo. The residue was diluted with water (50 mL) and the resulting mixture was extracted with a mixed solvent of DCM/MeOH (10/1 (v/v), 80 mLx 3). The combined organic layers were dried over anhydrous Na2S04 and concentrated in vacuo to give the title compound as a brown solid (445.4 mg), which was used directly in the next step without further purification. MS (ESI, pos.ion) m/z: 313.2 [M+H]+.

The synthetic route of 944718-31-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 944718-31-4, These common heterocyclic compound, 944718-31-4, name is 5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Bromo-1-methyl-benzotriazole (500.00 mg, 2.36 mmol), Pd(OAc)2 (52.98 mg,236.00 umol), tris-o-tolylphosphane (143.66 mg, 472.00 umol), DIPEA (915.02 mg,) in DMF (8.00 mL) was added methyl prop-2-enoate (2.03 g, 23.60 mmol, 2.12 mL), DIPEA (915.02 mg, 7.08 mmol, 1.24 mL) and degassed and microwaved at 130 C for 2h. After filtration through celite and diluted with EtOAc, the solution was washed with water and brine and dried over Na2SO4. Si gel chromatography gave methyl (E)-3-(1- methylbenzotriazol-5-yl)prop-2-enoate (240 mg, 47% yield). LCMS: Rt = 1.04 mm, mlz =218.

Statistics shows that 5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole is playing an increasingly important role. we look forward to future research findings about 944718-31-4.

Reference:
Patent; BIOGEN MA INC.; CAPACCI, Andrew, George; DECHANTSREITER, Michael; ENYEDY, Istvan; JONES, John, H.; LIN, Edward, Yin-Shiang; LUCAS, Brian, Stuart; MA, Bin; (273 pag.)WO2018/140876; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary