Some common heterocyclic compound, 932-87-6, name is (Bromoethynyl)benzene, molecular formula is C8H5Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H5Br
General procedure: A 5.0 mL of reaction tube was charged with organoboron compound (1.0 mmol), alkynyl bromide (1.0 mmol), CuI (0.10 mmol), 8-hydroxyquinoline (0.20 mmol), ethanol (2.0 mmol). The mixture was stirred at 80 C for 24 h, and then washed with ethyl acetate (3.0 mL×3), the combined ethyl acetate was concentrated under reduced pressure. The obtained residue was purified by flash column chromatography on silica gel (petroleum ether as eluting agent) to give the corresponding pure cross-coupling product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 932-87-6, its application will become more common.
Reference:
Article; Wang, Shihua; Wang, Min; Wang, Lei; Wang, Bo; Li, Pinhua; Yang, Jin; Tetrahedron; vol. 67; 26; (2011); p. 4800 – 4806;,
Bromide – Wikipedia,
bromide – Wiktionary