Application of 91319-54-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 91319-54-9, name is 1-(2-Bromoethyl)-2-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 134 Synthesis of 1-[1-(2-fluorophenethyl)piperidin-4-yl]-6-acetamidomethylindoline 1-(Piperidin-4-yl)-6-acetamidomethylindoline (250 mg) and 2-fluorophenethyl bromide (220 mg) were treated as in Example 2 to give the title compound (190 mg) as a white-powder (yield: 52%). m.p.: 160-161 C. 1H-NMR (400 MHz, CDCl3): delta(ppm) 1.51-1.68(2H, m), 1.81-1.92(2H, m), 2.00(3H, s), 2.20-2.40(2H, m), 2.70-2.89(4H, m), 2.91(2H, t, J=8Hz), 3.01-3.10(2H, m), 3.40-3.48(3H, m), 4.32(2H, d, J=6Hz), 6.39(1H, s), 6.51(1H, d, J=8Hz), 6.98-7.10(3H, m), 7.18-7.30(2H, m). FAB-Mass: 396(MH+).
The synthetic route of 1-(2-Bromoethyl)-2-fluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eisai Co., Ltd.; US2002/19531; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary