Category: 90868-92-1

Related Products of 90868-92-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 90868-92-1, name is (4-Bromophenyl)(cyclopropyl)methanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Production Example 29; To a mixture of 1-(4-bromophenyl)-1-cyclopropylmethane amine (1.08 g) and THF (10 mL) were added triethylamine (1 mL) and di-tert-butyl dicarbonate (1.25 mL), and the mixture was stirred at room temperature for 16 hours. The solvent was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain tert-butyl [(4-bromophenyl)(cyclopropyl)methyl]carbamate (1.36 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-Bromophenyl)(cyclopropyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Astellas Pharma Inc.; EP2277858; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 90868-92-1,Some common heterocyclic compound, 90868-92-1, name is (4-Bromophenyl)(cyclopropyl)methanamine, molecular formula is C10H12BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Triphosgene (1.31 g) was added at once to a vigorously stirred mixture ofNaHCO3 (2.14 g) in water (50 ml.) and (4-bromo-phenyl)-cyclopropyl-methylamine (2.50 g) in dichloromethane (50 ml.) chilled in an ice bath. The cooling bath was removed and the mixture was stirred at room temperature for another 30 min. Then the organic phase was separated and dried (MgSO4) and the solvent was evaporated to afford the isocyanate as an oil that was directly submitted to the next reaction step. Yield: 2.88 g (quantitative); Mass spectrum (ESI ): m/z = 250/252 (Br) [M-H]”.

The synthetic route of 90868-92-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HIMMELSBACH, Frank; WO2010/139673; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary