New downstream synthetic route of C18H11Br

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromobenzo[c]phenanthrene, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 89523-51-3, name is 5-Bromobenzo[c]phenanthrene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89523-51-3, Application In Synthesis of 5-Bromobenzo[c]phenanthrene

Under an argon atmosphere, 10.1g g of 5-bromobenzo[c] phenanthrene which had been prepared in Synthesis Example 1 was placed in a flask. 400 mL of dehydrated ether was added to this flask. The reaction solution was cooled to -40 C, and 22 ml of 1.6M hexane solution of n-butyllithium was added. The resultant was heated to 0 C, and stirred for an hour. The reaction solution was cooled to -60 C, and 10 mL. of a dehydrated ether solution of 14.4g of triisopropyl borate was dripped. The reaction solution was stirred for 5 hours while heating to room temperature. 100 mL of a 10% hydrochloric acid solution was added and the mixture was stirred for an hour. An aqueous phase was removed, and an organic phase which had been separated was washed with water and saturated brine, and then dried with magnesium sulfate. After the magnesium sulfate was filtered out, the organic phase was concentrated. The solids obtained were washed with hexane, whereby 5.37g (yield: 60%) of benzo[c]phenanthrene-5-boronic acid was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromobenzo[c]phenanthrene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2218706; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

The origin of a common compound about 89523-51-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromobenzo[c]phenanthrene, its application will become more common.

Related Products of 89523-51-3,Some common heterocyclic compound, 89523-51-3, name is 5-Bromobenzo[c]phenanthrene, molecular formula is C18H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an argon atmosphere, 3.07g of the 5-bromobenzo[c]phenanthrene which had been prepared in Synthesis Example 1, 4.18g of 10-(2-naphthyl)anthracene -9-boronic acid which had been synthesized by a known method, 0.231 g of tetraxis(triphenylphosphine)palladium(0), 40 mL of toluene and 20 mL of a 2M aqueous solution of sodium carbonate were charged. The resultant was refluxed with stirring for 8 hours. After cooling to room temperature, the reaction solution was extracted with toluene. An aqueous phase was removed, and an organic phase which had been separated was washed with water and saturated brine sequentially, and then dried with magnesium sulfate. After the magnesium sulfate was filtered out, the organic phase was concentrated. The resulting residue was purified by a silica gel column chromatography, whereby 4.13g of pale yellow crystals were obtained. As a result of mass spectrometry, the resulting crystals were confirmed to be the above-mentioned compound 1. The compound 1 had an m/e value of 530 with respect to a molecular weight of 530.20.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromobenzo[c]phenanthrene, its application will become more common.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2218706; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

The important role of 5-Bromobenzo[c]phenanthrene

According to the analysis of related databases, 89523-51-3, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89523-51-3 as follows. Product Details of 89523-51-3

(A-4) Synthesis of benzo(c)phenanthrene-5-boronic acid Under the atmosphere of argon, 10.1g of 5-bromobenzo[c]phenanthrene was placed in a flask, and 400 mL of dehydrated ether was added. The reaction solution was cooled to -40C, and 22 mL of a hexane solution of 1.6 M n-butyl lithium was added. The resultant was heated to 0C, and stirred for 1 hour. The reaction solution was cooled to -60C, and 10 mL of a dehydrated ether solution of 14.4g of triisopropyl borate was added dropwise. While heating the reaction solution to room temperature, stirring was continued for 5 hours. 10 mL of a 10% aqueous hydrochloric acid solution was added, followed by stirring for 1 hour. An aqueous phase was removed, and an organic phase was washed with water and saturated saline, and dried with magnesium sulfate. After filtering off magnesium sulfate, the organic phase was concentrated. The resulting solids were washed with hexane, whereby 5.37g (yield 60%) of benzo[c]phenanthrene-5-boronic acid as an intended product was obtained.

According to the analysis of related databases, 89523-51-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2524913; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Extracurricular laboratory: Synthetic route of C18H11Br

The synthetic route of 89523-51-3 has been constantly updated, and we look forward to future research findings.

Related Products of 89523-51-3, These common heterocyclic compound, 89523-51-3, name is 5-Bromobenzo[c]phenanthrene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Argon atmosphere, 2-nitro-phenylboronic acid 2.00g, 5-bromo-benzo [c] phenanthrene, 6.12g, tetrakis triphenylphosphine palladium (0) 0.462g, DME 80mL, 2M aqueous sodium carbonate solution in the flask was added 40mL and the mixture was heated and stirred 24 hr reflux. after cooling to room temperature (25 ), after the reaction solution was extracted using toluene, and removing the water layer, an organic layer was washed with saturated aqueous sodium chloride. The organic layer was dried over magnesium sulfate, concentrated, and the residue was purified by silica gel column chromatography to give 5- (2-nitro-phenyl) benzo [c] phenanthrene was obtained a 5.72g.

The synthetic route of 89523-51-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Idemitsu Kosan Corporation; Kawamura, Masahiro; Mizuki, Yumiko; Ito, Hirokazu; Hayama, Tomoharu; Haketa, Tasuku; (69 pag.)KR2015/126340; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of 89523-51-3

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89523-51-3, name is 5-Bromobenzo[c]phenanthrene, A new synthetic method of this compound is introduced below., COA of Formula: C18H11Br

Example 4 Synthesis of 5-(diphenylamino)benzo[c]phenanthrene 190 mul (1 mmol) of chlorodi-tert-butylphosphine and then 112 mg (0.5 mmol) of palladium(II) acetate are added to a suspension of 15.3 g (50 mmol) of 5-bromobenzo[c]phenanthrene, 10.2 g (60 mmol) of diphenylamine and 7.7 g (80 mmol) of sodium tert-butoxide in 500 ml of toluene, and the mixture is subsequently heated under reflux for 5 h. After the mixture has been cooled to 60 C., 500 ml of water are added, the organic phase is separated off, filtered through silica gel, evaporated virtually to dryness at 80 C. in vacuo, and 300 ml of ethanol are then added. After cooling, the solid is filtered off with suction. The product is purified by recrystallisation from dioxane five times (about 8 ml/g). Yield: 12.6 g (32 mmol), 64.1%, purity 99.9% (HPLC).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Merck Patent GmbH; US2011/288292; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Simple exploration of 5-Bromobenzo[c]phenanthrene

According to the analysis of related databases, 89523-51-3, the application of this compound in the production field has become more and more popular.

Related Products of 89523-51-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89523-51-3 as follows.

Argon atmosphere, 3-bromo-fluoranthene 12.3g, 2-chloroaniline 5.60g, tris-dibenzylideneacetone dipalladium (0) 0.732g, Tri-t-butylphosphine tetrafluoroborate dihydro 0.926g borate, -t- sodium butoxide, 7.68g, was stirred in a 400mL flask, and dehydrated toluene, heated at 80 8 hours. After cooling to room temperature (25 ), the reaction solution was extracted with toluene, and was filtered through Celite. Filtrate was concentrated, and the residue was purified by column chromatography on silica gel, 5- (2-chloro-2,3,4) benzo [c] phenanthrene was obtained a 11.32g.

According to the analysis of related databases, 89523-51-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Idemitsu Kosan Corporation; Kawamura, Masahiro; Mizuki, Yumiko; Ito, Hirokazu; Hayama, Tomoharu; Haketa, Tasuku; (69 pag.)KR2015/126340; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

The important role of C18H11Br

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89523-51-3, name is 5-Bromobenzo[c]phenanthrene, A new synthetic method of this compound is introduced below., SDS of cas: 89523-51-3

a) Synthesis of benzo[c]phenanthrene-5-boronic acid 52 ml (130 mmol) of n-buthyllithium (2.5 M in n-hexane) are added dropwise to a suspension of 30.7 g (100 mmol) of 5-bromobenzo[c]phenanthrene in 1000 ml of THF at -78 C. with vigorous stirring, and the mixture is stirred for a further 2 h. 16.7 ml (150 mmol) of trimethyl borate are added to the red solution in one portion with vigorous stirring, the mixture is stirred at -78 C. for a further 30 min., then warmed to room temperature over the course of 3 h, 300 ml of water are added, and the mixture is stirred for 30 min. The organic phase is separated off and evaporated to dryness in vacuo. The solid is taken up in 100 ml of n-hexane, filtered off with suction, washed once with 100 ml of hexane and dried in vacuo. Yield: 24.8 g (91 mmol), 91%, purity about 90% (NMR) of boronic acid, with varying amounts of boronic anhydride and boronic acid. The boronic acid can be used in this form without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Merck Patent GmbH; US2011/288292; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary