Adding a certain compound to certain chemical reactions, such as: 89523-51-3, name is 5-Bromobenzo[c]phenanthrene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89523-51-3, Application In Synthesis of 5-Bromobenzo[c]phenanthrene
Under an argon atmosphere, 10.1g g of 5-bromobenzo[c] phenanthrene which had been prepared in Synthesis Example 1 was placed in a flask. 400 mL of dehydrated ether was added to this flask. The reaction solution was cooled to -40 C, and 22 ml of 1.6M hexane solution of n-butyllithium was added. The resultant was heated to 0 C, and stirred for an hour. The reaction solution was cooled to -60 C, and 10 mL. of a dehydrated ether solution of 14.4g of triisopropyl borate was dripped. The reaction solution was stirred for 5 hours while heating to room temperature. 100 mL of a 10% hydrochloric acid solution was added and the mixture was stirred for an hour. An aqueous phase was removed, and an organic phase which had been separated was washed with water and saturated brine, and then dried with magnesium sulfate. After the magnesium sulfate was filtered out, the organic phase was concentrated. The solids obtained were washed with hexane, whereby 5.37g (yield: 60%) of benzo[c]phenanthrene-5-boronic acid was obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromobenzo[c]phenanthrene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2218706; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary