Category: 89359-54-6

Adding a certain compound to certain chemical reactions, such as: 89359-54-6, name is 9-Bromo-1-nonene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89359-54-6, category: bromides-buliding-blocks

EXAMPLE 4 Sodium hydride (343 mg, 14 mmol) was added to a stirring solution of 1-methylthymine (2.00 g, 14 mmol) in dimethylsulfoxide (40 ml). After 15 minutes, 9-bromo-1-nonene (2.93 g, 14 mmol, available from Alfebro) was added and the resulting mixture stirred for 20 hours. The reaction was poured into water (40 ml) and extracted with three 50 ml aliquots of dichloromethane. The organic layers were combined, washed with water (40 ml) and saturated aqueous salt solution (20 ml). After drying the washed organic layers over sodium sulfate, the solvent was evaporated, leaving a colorless oil, 3-(8-nonenyl)-1-methylthymine, which solidified upon standing (2.76 g, 73% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 9-Bromo-1-nonene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Cell Therapeutics, Inc.; US5807862; (1998); A;; ; Patent; Cell Therapeutics, Inc.; US6043250; (2000); A;; ; Patent; Cell Therapeutics, Inc.; US6100271; (2000); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 89359-54-6, These common heterocyclic compound, 89359-54-6, name is 9-Bromo-1-nonene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a flame dried 500 mL RB flask, freshly activated Mg turnings (9 g) were added and the flask was equipped with a magnetic stir bar, an addition funnel and a reflux condenser. This set-up was degassed and flushed with argon and 100 mL of anhydrous ether was added to the flask via syringe. The bromide 3 (51.3 g, 250 mmol) was dissolved in anhydrous ether (100 mL) and added to the addition funnel. About 5 mL of this ether solution was added to the Mg turnings while stirring vigorously. An exothermic reaction was noticed (to confirm/accelerate the Grignard reagent formation, 5 mg of iodine was added and immediate decolorization was observed confirming the formation of the Grignard reagent) and the ether started refluxing. The rest of the solution of the bromide was added dropwise while keeping the reaction under gentle reflux by cooling the flask in water. After the completion of the addition the reaction mixture was kept at 35 C for 1 hour and then cooled in ice bath. Ethyl formate (9 g, 121 mmol) was dissolved in anhydrous ether (100 mL) and transferred to the addition funnel and added dropwiseto the reaction mixture with stirring. An exothermic reaction was observed and the reaction mixture started refluxing. After the initiation of the reaction the rest of the ethereal solution of formate was quickly added as a stream and the reaction mixture was stirred for a further period of 1 h at ambient temperature. The reaction was quenched by adding 10 mL of acetone dropwise followed by ice cold water (60 mL). The reaction mixture was treated with aq. H2S04 (10 % by volume, 300 mL) until the solution became homogeneous and the layers were separated. The aq. phase was extracted with ether (2×200 mL). The combined ether layers were dried (Na2S04) and concentrated to afford the crude product which was purified by column (silica gel, 0-10% ether in hexanes) chromatography. The product fractions were evaporated to provide the pure product 249 as a white solid (30.6 g, 90%). 1H NMR (400 MHz, CDC13) delta 7.26 (s, 1H), 5.81 (ddt, J = 16.9, 10.2, 6.7 Hz, 8H), 5.04 – 4.88 (m, 16H), 3.57 (dd, J = 7.6, 3.3 Hz, 4H), 2.04 (q, J = 6.9 Hz, 16H), 1.59 (s, 1H), 1.45 (d, J = 7.5 Hz, 8H), 1.43 – 1.12 (m, 94H), 0.88 (t, J = 6.8 Hz, 2H). 13C NMR (101 MHz, cdcl3) delta 139.40, 114.33, 77.54, 77.22, 76.90, 72.21, 37.70, 34.00, 29.86, 29.67, 29.29, 29.12, 25.85.

The synthetic route of 89359-54-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALNYLAM PHARMACEUTICALS, INC.; MAIER, Martin; JAYARAMAN, Muthusamy; AKINC, Akin; MATSUDA, Shigeo; KADASAMY, Pachamuthu; RAJEEV, Kallanthottathil, G.; MANOHARAN, Muthiah; WO2013/86354; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

89359-54-6, A common compound: 89359-54-6, name is 9-Bromo-1-nonene, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Synthesis of compound 19 ?CF2CF3 ^CF2CF3 19 A 5 ml flask was charged with alkene 6 (0.5 g, 2.44 mmol), thiol CF3CF2(CH2)3SH (0.47 g, 2.44 mmol), 2,2-dimethoxy-2-phenyl-acetophenone (12 mg, 0.05 mmol) and CHCI3 (1 .5 ml) and purged with nitrogen atmosphere. The mixture was stirred at room temperature and irradiated with UV black light for 3 h (lambda = 365-368 nm, 15W). The mixture was concentrated by evaporating the solvent. An oil was obtained (0.96 g, 192%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 9-Bromo-1-nonene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CRYSTAL PHARMA, S.A.U.; PEREZ ENCABO, Alfonso; TURIEL HERNANDEZ, Jose Angel; GALLO NIETO, Francisco Javier; LORENTE BONDE-LARSEN, Antonio; GARCIA ESCUDERO, Luis Angel; WO2015/181116; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary