Category: 88223-35-2

Synthetic Route of 88223-35-2, These common heterocyclic compound, 88223-35-2, name is 2-Bromo-9,9-dibutyl-9H-fluorene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3 parts of 4-tert-butylaniline,8.9 parts of 2-bromo-9,9-dibutylfluorene,0.23 parts of palladium (II) acetate,1.9 parts of 2,2-bis (diphenylphosphino) -1,1′-binaphthyl and 2.9 parts of sodium tert-butoxide were added to 35 parts of toluene and reacted under heating reflux condition for 15 hours.The reaction mixture was added drop-Extraction with chloroform – water,After concentrating the chloroform phase,Separation by column chromatography (ethyl acetate – hexane)Purified,4 parts of a compound represented by the following formula (300) as a yellow solid.

The synthetic route of 88223-35-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Kayaku Corporation; Satake, Masamitsu; (71 pag.)JP2016/196424; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 88223-35-2, name is 2-Bromo-9,9-dibutyl-9H-fluorene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 88223-35-2, name: 2-Bromo-9,9-dibutyl-9H-fluorene

General procedure: 2-Bromo-9,9-dialkylfluorene (10.0 mmol, 1a, 1b or 1c) was dissolved in CH2Cl2 (60 mL), in the presence of a supported catalystof SiO2/H2SO4 (4.60 g) prepared according to the literature procedure.31 HNO3 (417 mL, 10.0 mmol) was added, and the heterogeneous mixture was stirred at room temperature for 10 min. The solution was then filtered, and the filtrate was washed with aqueous saturated NaHCO3 solution (10 mL) and water (10 mL). The organic layer was dried over anhydrous MgSO4 and the solvent was evaporated under reduced pressure.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-9,9-dibutyl-9H-fluorene, and friends who are interested can also refer to it.

Reference:
Article; Lazar, Laszlo; Nagy, Miklos; Racz, David; Zsuga, Miklos; Keki, Sandor; Tetrahedron; vol. 70; 23; (2014); p. 3691 – 3699;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 88223-35-2, These common heterocyclic compound, 88223-35-2, name is 2-Bromo-9,9-dibutyl-9H-fluorene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of benzoyl chloride (1.05 ml; 13.5 mmol), AlCl3 (2 g; 15 mmol) and2-bromo-9,9-dibutyl-9H-fluorene (4.0 g; 9.0 mmol) in CS2 (80 mL) was prepared and purged with argon. Themixture was stirred for 16 h under argon. After the solvent was evaporated, the aqueous layer was extractedwith DCM. The combined organic layer was washed with water and dried over MgSO4. The residue waspurified by column chromatography on silica gel (hexane : DCM = 1 : 1).Yield: white solid (415 mg; 9.0 mmol; 99 %).1H-NMR (300 MHz, DMSO-d6): delta 7.84-7.73 (m, 5H), 7.65-7.58 (m, 2H), 7.52-7.48 (m, 4H), 2.07-1.89 (m, 4H),1.16-1.03 (m, 4H), 0.68 (t, 6H), 0.66-0.54 (m, 4H).

Statistics shows that 2-Bromo-9,9-dibutyl-9H-fluorene is playing an increasingly important role. we look forward to future research findings about 88223-35-2.

Reference:
Article; Wada, Atsushi; Nishida, Jun-Ichi; Maitani, Masato M.; Wada, Yuji; Yamashita, Yoshiro; Chemistry Letters; vol. 43; 3; (2014); p. 296 – 298;,
Bromide – Wikipedia,
bromide – Wiktionary

88223-35-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 88223-35-2, name is 2-Bromo-9,9-dibutyl-9H-fluorene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In a 250 mL round bottom flask was placed 7 (14.2 g, 40 mmol). The flask was evacuated under vacuum and flushed with nitrogen three times. THF (150 mL) was then added. The mixture was cooled to -78 C and n-BuLi (19.2 mL, 48 mmol) was slowly added. After the mixture was stirred for 5 h at -78 C, trimethyl borate (5.6 mL, 48 mmol) was injected. After 2 h, the mixture was slowly warmed to room temperature. HCl (3 M, 150 mL) solution was added and the mixture was stirred for another 3 h. The mixture was extracted with DCM three times. The combined organic layers were washed with water, dried over anhydrous sodium sulfate. The product was then dried under high vacuum. The crude product was condensed and purified on a silica-gel column using a mixture of DCM and acetone (5:1 by volume) as eluent. A white solid 4d (5.83 g, 45.3% yield) was obtained; m.p. 145-148 C. 1H NMR (300 MHz, d6-DMSO): delta (ppm): 7.98 (s, 2H), 7.83 (s, 1H), 7.74-7.82 (m, 3H), 7.43-7.45 (m, 1H), 7.31-7.34 (m, 2H), 1.95-1.99 (m, 4H), 0.98-1.06 (m, 4H), 0.61 (t, 6H, J = 7.5 Hz), 0.46-0.50 (m, 4H).

The synthetic route of 2-Bromo-9,9-dibutyl-9H-fluorene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhu, Tianhao; He, Guangke; Chang, Jin; Zhao, Dongdong; Zhu, Xiaolin; Zhu, Hongjun; Dyes and Pigments; vol. 95; 3; (2012); p. 679 – 688;,
Bromide – Wikipedia,
bromide – Wiktionary