Category: 881676-32-0

Nishida, Haruyuki et al. published their research in Bioorganic & Medicinal Chemistry in 2017 | CAS: 881676-32-0

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 881676-32-0

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action was written by Nishida, Haruyuki;Arikawa, Yasuyoshi;Hirase, Keizo;Imaeda, Toshihiro;Inatomi, Nobuhiro;Hori, Yasunobu;Matsukawa, Jun;Fujioka, Yasushi;Hamada, Teruki;Iida, Motoo;Nishitani, Mitsuyoshi;Imanishi, Akio;Fukui, Hideo;Itoh, Fumio;Kajino, Masahiro. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Recommanded Product: 881676-32-0 This article mentions the following:

With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative I as a lead compound As part of a comprehensive approach to identification of a new drug, we explored excellent compounds that have low lipophilicity by introducing a polar hetero-aromatic group at position 5 of the pyrrole ring. Among the compounds synthesized, fluoropyrrole derivativeII, which has a 2-fluoro-3-pyridyl group at the fifth position, lower pKa, and much lower C log P and log D values than I does, showed potent gastric-acid suppressive action resulting from gastric H+,K+-ATPase inhibition in animal models. Its maximum intragastric pH elevation effect was strong in rats, and its duration of action was much longer than that of either lansoprazole or lead compound I in dogs. Therefore, compound II can be considered a promising new P-CAB with long duration of action. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0Recommanded Product: 881676-32-0).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 881676-32-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nishida, Haruyuki et al. published their research in Bioorganic & Medicinal Chemistry in 2017 | CAS: 881676-32-0

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 881676-32-0

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action was written by Nishida, Haruyuki;Arikawa, Yasuyoshi;Hirase, Keizo;Imaeda, Toshihiro;Inatomi, Nobuhiro;Hori, Yasunobu;Matsukawa, Jun;Fujioka, Yasushi;Hamada, Teruki;Iida, Motoo;Nishitani, Mitsuyoshi;Imanishi, Akio;Fukui, Hideo;Itoh, Fumio;Kajino, Masahiro. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Recommanded Product: 881676-32-0 This article mentions the following:

With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative I as a lead compound As part of a comprehensive approach to identification of a new drug, we explored excellent compounds that have low lipophilicity by introducing a polar hetero-aromatic group at position 5 of the pyrrole ring. Among the compounds synthesized, fluoropyrrole derivativeII, which has a 2-fluoro-3-pyridyl group at the fifth position, lower pKa, and much lower C log P and log D values than I does, showed potent gastric-acid suppressive action resulting from gastric H+,K+-ATPase inhibition in animal models. Its maximum intragastric pH elevation effect was strong in rats, and its duration of action was much longer than that of either lansoprazole or lead compound I in dogs. Therefore, compound II can be considered a promising new P-CAB with long duration of action. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0Recommanded Product: 881676-32-0).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 881676-32-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nishida, Haruyuki et al. published their research in Bioorganic & Medicinal Chemistry in 2017 | CAS: 881676-32-0

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 881676-32-0

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action was written by Nishida, Haruyuki;Arikawa, Yasuyoshi;Hirase, Keizo;Imaeda, Toshihiro;Inatomi, Nobuhiro;Hori, Yasunobu;Matsukawa, Jun;Fujioka, Yasushi;Hamada, Teruki;Iida, Motoo;Nishitani, Mitsuyoshi;Imanishi, Akio;Fukui, Hideo;Itoh, Fumio;Kajino, Masahiro. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Recommanded Product: 881676-32-0 This article mentions the following:

With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative I as a lead compound As part of a comprehensive approach to identification of a new drug, we explored excellent compounds that have low lipophilicity by introducing a polar hetero-aromatic group at position 5 of the pyrrole ring. Among the compounds synthesized, fluoropyrrole derivativeII, which has a 2-fluoro-3-pyridyl group at the fifth position, lower pKa, and much lower C log P and log D values than I does, showed potent gastric-acid suppressive action resulting from gastric H+,K+-ATPase inhibition in animal models. Its maximum intragastric pH elevation effect was strong in rats, and its duration of action was much longer than that of either lansoprazole or lead compound I in dogs. Therefore, compound II can be considered a promising new P-CAB with long duration of action. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0Recommanded Product: 881676-32-0).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 881676-32-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary