On February 24, 2011, Sone, Toshihiko; Nakajima, Tomoko; Takai, Kentaro published a patent.Formula: C7H8BrCl2N The title of the patent was Preparation of bicyclic urea derivatives as soluble epoxide hydrolase inhibitors. And the patent contained the following:
Title compounds I [R1 = (un)substituted cycloalkyl, (un)substituted heterocyclyl, (un)substituted aryl, etc.; R2a, R2b = H, halo, hydroxy, etc.; m = 0-5; ring A = Q1, etc.; R3a, R3b, R3c = H, halo, hydroxy, etc.] or pharmaceutically acceptable salts thereof were prepared For example, alkxoycarbonylation of nortropine·HCl with Boc2O, reaction with 2-fluoropyridine, deprotection using HCl, and treatment with 4-(trifluoromethyl)phenylisocyanate afforded endo-II. In soluble epoxide hydrolase (sEH) inhibition assay, endo-II showed 97% inhibition activity. Compounds I are claimed useful for the treatment of hypertension, kidney disease (primary and secondary), etc. The experimental process involved the reaction of (4-Bromo-2-chlorophenyl)methanamine hydrochloride(cas: 874482-96-9).Formula: C7H8BrCl2N
The Article related to bicyclic urea preparation soluble epoxide hydrolase inhibitor, hypertension treatment bicyclic urea seh inhibition, primary secondary kidney disease treatment bicyclic urea seh inhibition and other aspects.Formula: C7H8BrCl2N
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary