Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions was written by Hardegger, Leo A.;Kuhn, Bernd;Spinnler, Beat;Anselm, Lilli;Ecabert, Robert;Stihle, Martine;Gsell, Bernard;Thoma, Ralf;Diez, Joachim;Benz, Joerg;Plancher, Jean-Marc;Hartmann, Guido;Banner, David W.;Haap, Wolfgang;Diederich, Francois. And the article was included in Angewandte Chemie, International Edition in 2011.Name: 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid This article mentions the following:
Halogen bonding triggers activity. Increasing binding affinity was observed for a series of covalent human Cathepsin L inhibitors by exchanging an aryl ring H atom with Cl, Br, and I, which undergo halogen bonding with the C=O group of Gly61 in the S3 pocket of the enzyme. Fluorine, in contrast, strongly avoids halogen bonding. The strong distance and angle dependence of halogen bonding was confirmed for biol. systems. In the experiment, the researchers used many compounds, for example, 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid (cas: 872422-15-6Name: 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid).
1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid (cas: 872422-15-6) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Name: 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary