3-Bromo-4-(trifluoromethoxy)benzaldehyde(cas: 85366-66-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. SDS of cas: 85366-66-1
Schuetz, Ramona; Mueller, Martin; Geisslinger, Franz; Vollmar, Angelika; Bartel, Karin; Bracher, Franz published their research in European Journal of Medicinal Chemistry on December 1 ,2020. The article was titled 《Synthesis, biological evaluation and toxicity of novel tetrandrine analogues》.SDS of cas: 85366-66-1 The article contains the following contents:
In this work, the design and synthesis of novel fully synthetic analogs of the bisbenzylisoquinoline tetrandrines e.g., I, a mol. with numerous pharmacol. properties and the potential to treat life-threatening diseases, such as viral infections and cancer were presented. Its toxicity to liver and lungs and the underlying mechanisms, however, are controversially discussed. Along this line, novel tetrandrine analogs e.g., I were synthesized and biol. evaluated for their hepatotoxicity, as well as their antiproliferative and chemoresistance reversing activity on cancer cells. Previous studies suggesting CYP-mediated toxification of tetrandrine prompted to amend/replace the suspected metabolically instable 12-methoxy group. Of note, employing several in vitro models showed that the proposed CYP3A4-driven metabolism of tetrandrine and analogs is not the major cause of hepatotoxicity. Biol. characterization revealed that some of the novel tetrandrine analogs e.g., I sensitized drug-resistant leukemia cells by inhibition of the P-glycoprotein. Interestingly, direct anticancer effects improved in comparison to tetrandrine, as several compounds displayed markedly enhanced ability to reduce proliferation of drug-resistant leukemia cells and to induce cell death of liver cancer cells. Those enhanced anticancer properties were linked to influences on activation of the kinase Akt and mitochondrial events. In sum, the role of CYP3A4-mediated toxicity of the bisbenzylisoquinoline alkaloid tetrandrine and the basis for exploitation of novel synthetic analogs for their antitumoral potential were clarified. The experimental process involved the reaction of 3-Bromo-4-(trifluoromethoxy)benzaldehyde(cas: 85366-66-1SDS of cas: 85366-66-1)
3-Bromo-4-(trifluoromethoxy)benzaldehyde(cas: 85366-66-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. SDS of cas: 85366-66-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary