Category: 83902-02-7

Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098 was written by Kurz, Thomas;Schlueter, Katrin;Kaula, Uwe;Bergmann, Baerbel;Walter, Rolf D.;Geffken, Detlef. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Safety of 2-(Bromomethyl)-1,3-dimethylbenzene This article mentions the following:

Fosmidomycin is a promising antimalarial drug candidate with a unique chem. structure and a novel mode of action. Chain substituted pivaloyloxymethyl ester derivatives of Fosmidomycin and its acetyl analog FR900098 have been synthesized and their in vitro antimalarial activity vs. the Chloroquine sensitive strain 3D7 of Plasmodium falciparum has been determined In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Safety of 2-(Bromomethyl)-1,3-dimethylbenzene).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of 2-(Bromomethyl)-1,3-dimethylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs) was written by Bailey, Nick;Bamford, Mark J.;Brissy, Delphine;Brookfield, Joanna;Demont, Emmanuel;Elliott, Richard;Garton, Neil;Farre-Gutierrez, Irene;Hayhow, Thomas;Hutley, Gail;Naylor, Antoinette;Panchal, Terry A.;Seow, Hui-Xian;Spalding, David;Takle, Andrew K.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Category: bromides-buliding-blocks This article mentions the following:

Acid pump antagonists (APAs) such as the imidazo[1,2-a]pyridine AZD-0865 I have proven efficacious at low oral doses in acid related gastric disorders. Herein some of the broader SAR in this class of mol. are described and detail the discovery of an imidazo[1,2-a]pyridine II which has excellent efficacy in animal models of gastric acid secretion following oral administration, as well as a good overall developability profile. The discovery strategy focuses on use of heteroaryl and heterocyclic substituents at the C-6 position and optimization of developability characteristics through modulation of global physico-chem. properties. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Category: bromides-buliding-blocks).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Desymmetrization of difluoromethylene groups by C-F bond activation was written by Butcher, Trevor W.;Yang, Jonathan L.;Amberg, Willi M.;Watkins, Nicholas B.;Wilkinson, Natalie D.;Hartwig, John F.. And the article was included in Nature (London, United Kingdom) in 2020.Application of 83902-02-7 This article mentions the following:

Tertiary stereogenic centers containing one fluorine atom are valuable for medicinal chem. because they mimic common tertiary stereogenic centers containing one hydrogen atom, but they possess distinct charge distribution, lipophilicity, conformation and metabolic stability^1-3. Although tertiary stereogenic centers containing one hydrogen atom are often set by enantioselective desymmetrization reactions at one of the two carbon-hydrogen (C-H) bonds of a methylene group, tertiary stereocenters containing fluorine have not yet been constructed by the analogous desymmetrization reaction at one of the two carbon-fluorine (C-F) bonds of a difluoromethylene group³. Fluorine atoms are similar in size to hydrogen atoms but have distinct electronic properties, causing C-F bonds to be exceptionally strong and geminal C-F bonds to strengthen one another⁴. Thus, exhaustive defluorination typically dominates over the selective replacement of a single C-F bond, hindering the development of the enantioselective substitution of one fluorine atom to form a stereogenic center^5,6. Here the authors report the catalytic, enantioselective activation of a single C-F bond in an allylic difluoromethylene group to provide a broad range of products containing a monofluorinated tertiary stereogenic center. By combining a tailored chiral iridium phosphoramidite catalyst, which controls regioselectivity, chemoselectivity and enantioselectivity, with a fluorophilic activator, which assists the oxidative addition of the C-F bond, these reactions occur in high yield and selectivity. The design principles proposed in this work extend to palladium-catalyzed benzylic substitution, demonstrating the generality of the approach. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Application of 83902-02-7).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 83902-02-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Transition-Metal-Free Synthesis of Unsymmetrical Disulfides via Three-Component Reaction of Thiosulfonates, Thiourea and Alkyl halides was written by Wang, Dungai;He, Quan;Shi, Keqiang;Xiong, Mingteng;Zhou, Yifeng;Pan, Yuanjiang. And the article was included in Advanced Synthesis & Catalysis in 2021.Electric Literature of C9H11Br This article mentions the following:

A transition-metal-free approach to synthesize unsym. disulfides RSSR¹ [R = (4-methoxyphenyl)methyl, (1-[(tert-butoxy)carbonyl]piperidin-4-yl)methyl, quinolin-8-ylmethyl, etc.; R¹ = Bu, quinolin-8-ylmethyl, (2-oxo-1,2-dihydroquinolin-4-yl)methyl, etc.] is reported that relies on a K₂CO₃-promoted one-pot reaction of thiosulfonates RSS(O)₂C₆H₄(4-CH₃), thiourea and alkyl halides R¹X (X = Br, Cl, I, OTs) under mild conditions. The protocol tolerates a wide range of substrates, leading to various types of unsym. disulfides in moderate to excellent yields. More importantly, the late-stage modification of natural products and drug mols. was also achieved. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Electric Literature of C9H11Br).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary