Category: 82842-52-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 82842-52-2, name is 3-Bromo-2,4,6-trimethylaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 82842-52-2

Second Step To a solution of 3-bromo-2,4,6-trimethylaniline (2.0 g, 9.18 mmol) in DMSO (25 mL) was added iodoethane (1.86 mL, 44.9 mmol) and potassium carbonate (5.06 g, 36.6 mmol), and the solution was heated to 60 C. for 16 hours and cooled to room temperature. The mixture was diluted with ethyl acetate (300 mL), washed with saturated NaCl (2*), and dried over magnesium sulfate. The solvent was removed under reduced pressure. The crude product was purified by column chromatography (silica gel) with hexane/ethyl acetate as the mobile phase to give 1-(N,N-diethylamine)-3-bromo-2,4,6-trimethylbenzene (4.0 g, 54%). as a colorless liquid.

The synthetic route of 82842-52-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wu, Chengde; Anderson, C. Eric; Bui, Huong; Gao, Daxin; Kassir, Jamal; Li, Wen; Wang, Junmei; Biediger, Ronald; Chen, Jie; Market, Robert V.; US2005/49286; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 82842-52-2 as follows. Quality Control of 3-Bromo-2,4,6-trimethylaniline

EXAMPLE 207 ‘N-(2,2′,4,6,6′-Pentamethyl-1,1’-biphenyl-3-yl)-3-[(phenylsulfonyl)amino]thiophene-2-carboxamide Step One: To a solution of 3-bromo-2,4,6-trimethylaniline (1.07 g, 5.0 mmol) and 2,6-dimethylphenyl boronic acid (1.5 g, 10 mmol) in toluene (10 mL) was added potassium phosphate, tribasic (3.2 g, 15 mmol) and the resulting mixture was deoxygenated by passing a stream of nitrogen for approximately 10 minutes. 2-Dicyclohexylphosphino-2,6-dimethoxy-1,1’biphenyl (0.164 g, 0.4 mmol) and tris(dibenzylidineacetone)dipalladium(0) (92 mg, 0.1 mmol) were added together in one portion, and nitrogen bubbling continued for approximately 2 minutes. The mixture was then heated in an oil bath at 110 C. under nitrogen overnight. The mixture was cooled, concentrated and passed through a pad of course silica gel. The resulting residue was purified on silica using 14:1 to hexanes to ethyl acetate. The residue from this operation was then vacuum distilled (Kugelrohr, 100 C., approximately 1 mtorr) to give the desired biphenyl (155 mg).

According to the analysis of related databases, 82842-52-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wu, Chengde; Anderson, C. Eric; Bui, Huong; Gao, Daxin; Kassir, Jamal; Li, Wen; Wang, Junmei; Biediger, Ronald; Chen, Jie; Market, Robert V.; US2005/49286; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 82842-52-2, name is 3-Bromo-2,4,6-trimethylaniline, A new synthetic method of this compound is introduced below., SDS of cas: 82842-52-2

Second Step To a solution of 3-bromo-2,4,6-trimethylaniline (2.0 g, 9.18 mmol) in DMSO (25 mL) was added iodoethane (1.86 mL, 44.9 mmol) and potassium carbonate (5.06 g, 36.6 mmol), and the solution was heated to 60 C. for 16 hours and cooled to room temperature. The mixture was diluted with ethyl acetate (300 mL), washed with saturated NaCl (2*), and dried over magnesium sulfate. The solvent was removed under reduced pressure. The crude product was purified by column chromatography (silica gel) with hexane/ethyl acetate as the mobile phase to give 1-(N,N-diethylamine)-3-bromo-2,4,6-trimethylbenzene (4.0 g, 54%). as a colorless liquid.

The synthetic route of 82842-52-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wu, Chengde; Anderson, C. Eric; Bui, Huong; Gao, Daxin; Kassir, Jamal; Li, Wen; Wang, Junmei; Biediger, Ronald; Chen, Jie; Market, Robert V.; US2005/49286; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 82842-52-2, name is 3-Bromo-2,4,6-trimethylaniline, This compound has unique chemical properties. The synthetic route is as follows., 82842-52-2

(B) 2,2′-[[2-[(3-bromo-2,4,6-trimethylphenyl)amino]-2-oxoethyl]]imino]bisacetic acid A suspension of 9.56 g of nitrilotriacetic acid in pyridine (dried over molecular sieves) is prepared with the exclusion of moisture (CaSO4 drying tube) and heated to 50 C. Acetic anhydride (5.11 g) is added dropwise. The reaction mixture clears and is heated to 100 C. After maintaining the temperature for 40 minutes, the reaction mixture is cooled to 55 C. and a solution of 10.7 g 3-bromo-2,4,6-trimethylaniline in 25 ml of dry pyridine is added slowly. The reaction is heated to 100 C. and after 1.5 hours at this temperature, the solution is cooled in an ice-bath. The reaction mixture is rotary evaporated to a semisolid which is dissolved in 125 ml of 10% sodium hydroxide w/v. The basic layer is then extracted with two 100 ml portions of methylene chloride. Distilled water (100 ml) is added to the basic layer which is then brought to pH 3 with concentrated hydrochloric acid to give a precipitate. After refrigeration for about 16 hours, the crude product is filtered, washed with cold distilled water and dried under vacuum at 40 C. The crude product is dissolved in 100 ml of 60% aqueous ethanol, treated with 3.0 g of Darco and filtered hot through a Hyflo-bed to give a solution. Crystals precipitate and are filtered, washed with three 25 ml portions of 50% aqueous ethanol and dried under vacuum at 40 C. The reaction yields 9.1 g of the title compound, melting point 198-200 C., dec.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; E. R. Squibb & Sons, Inc.; US4418208; (1983); A;,
Bromide – Wikipedia,
bromide – Wiktionary

82842-52-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 82842-52-2, name is 3-Bromo-2,4,6-trimethylaniline, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 200 Preparation of ‘N-(3-bromo-2,4,6-trimethylphenyl)-3-[(phenylsulfonyl)amino]thiophene-2-carboxamide. Step One: In an oven dried flask, 3-bromo-2,4,6-trimethylaniline (2.50 g, 11.4 mmol) was dissolved in toluene (30 mL). The mixture was cooled to 0 C. in an iced water bath. After addition of trimethylaluminum (5.60 mL, 11.22 mmol, 2.0 M in hexane) was complete, the solution was warmed to room temperature and stirred under N2 for 15 minutes. Methyl 3-amino-2-thiophene carboxylate (0.36 g, 2.3 mmol) was added in one portion. The reaction mixture was stirred at room temperature under N2 for 45 minutes. Thereafter, the mixture was heated to 115 C. for 16 hours. The reaction mixture was allowed to cool to room temperature and was quenched with ice. The aqueous phase was adjusted to pH 12 with 0.5 N NaOH and extracted with ethyl acetate. The resulted organic phase was washed with saturated NaCl twice and dried over magnesium sulfate. The solvent was removed under reduced pressure. The resulting crude product was purified by column chromatography with hexane/ethyl acetate as solvent. The amide (0.30 g, 39%) was obtained-as a light-yellow solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Wu, Chengde; Anderson, C. Eric; Bui, Huong; Gao, Daxin; Kassir, Jamal; Li, Wen; Wang, Junmei; Biediger, Ronald; Chen, Jie; Market, Robert V.; US2005/49286; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary