Category: 82702-31-6

Arylcyclopropanecarboxyl Guanidines as Novel, Potent, and Selective Inhibitors of the Sodium Hydrogen Exchanger Isoform-1 was written by Ahmad, Saleem;Doweyko, Lidia M.;Dugar, Sundeep;Grazier, Nyeemah;Ngu, Khehyong;Wu, Shung C.;Yost, Kenneth J.;Chen, Bang-Chi;Gougoutas, Jack Z.;DiMarco, John D.;Lan, Shih-Jung;Gavin, Brian J.;Chen, Alice Y.;Dorso, Charles R.;Serafino, Randy;Kirby, Mark;Atwal, Karnail S.. And the article was included in Journal of Medicinal Chemistry in 2001.Recommanded Product: Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

A novel series of arylcyclopropanecarboxyl guanidines was synthesized and evaluated for activity against the sodium hydrogen exchanger isoform-1 (NHE-1). In biol. assays conducted in an AP1 cell line expressing the human NHE-1 isoform, the starting cyclopropane (IC₅₀ = 3.5 μM) shows inhibitory activity comparable to cariporide (IC₅₀ = 3.4 μM). Structure-activity relationships are used to optimize the affinity of various acyl guanidines for NHE-1 by screening the effect of substituents at both aryl and cyclopropyl rings. It is demonstrated that introduction of appropriate hydrophobic groups at the Ph ring and a gem-di-Me group at the cyclopropane ring enhances the NHE-1 inhibitory activity by up to 3 orders of magnitude (IC₅₀ = 0.003 μM). In addition, the gem-di-Me series of analogs seem to display improved oral bioavailability and longer plasma half-life in rats. Furthermore, the lead benzodihydrofuranyl analog (BMS-284640) shows over 380-fold increased NHE-1 inhibitory activity as well as improved selectivity for NHE-1 over NHE-2 compared to cariporide. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Recommanded Product: Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity was written by Martin-Lopez, Juan;Codony, Sandra;Bartra, Clara;Morisseau, Christophe;Loza, Maria Isabel;Sanfeliu, Coral;Hammock, Bruce D.;Brea, Jose;Vazquez, Santiago. And the article was included in Pharmaceuticals in 2021.HPLC of Formula: 82702-31-6 This article mentions the following:

The pharmacol. inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids. Numerous potent sEH inhibitors (sEHI) have been developed, however many contain highly lipophilic substituents limiting their availability. Recently, a new series of benzohomoadamantane-based ureas endowed with potent inhibitory activity for the human and murine sEH was reported. However, their very low microsomal stability prevented further development. Herein, a new series of benzohomoadamantane-based amides were synthesized, fully characterized, and evaluated as sEHI. Most of these amides were endowed with excellent inhibitory potencies. A selected compound displayed anti-inflammatory effects with higher effectiveness than the reference sEHI, TPPU. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6HPLC of Formula: 82702-31-6).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 82702-31-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of a Novel Class of D-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform was written by Tang, Haifeng;Jensen, Kristian;Houang, Evelyne;McRobb, Fiona M.;Bhat, Sathesh;Svensson, Mats;Bochevarov, Art;Day, Tyler;Dahlgren, Markus K.;Bell, Jeffery A.;Frye, Leah;Skene, Robert J.;Lewis, James H.;Osborne, James D.;Tierney, Jason P.;Gordon, James A.;Palomero, Maria A.;Gallati, Caroline;Chapman, Robert S. L.;Jones, Daniel R.;Hirst, Kim L.;Sephton, Mark;Chauhan, Alka;Sharpe, Andrew;Tardia, Piero;Dechaux, Elsa A.;Taylor, Andrea;Waddell, Ross D.;Valentine, Andrea;Janssens, Holden B.;Aziz, Omar;Bloomfield, Dawn E.;Ladha, Sandeep;Fraser, Ian J.;Ellard, John M.. And the article was included in Journal of Medicinal Chemistry in 2022.Electric Literature of C8H6BrFO2 This article mentions the following:

D-Serine is a coagonist of the N-Me D-aspartate (NMDA) receptor, a key excitatory neurotransmitter receptor. In the brain, D-serine is synthesized from its L-isomer by serine racemase and is metabolized by the D-amino acid oxidase (DAO, DAAO). Many studies have linked decreased D-serine concentration and/or increased DAO expression and enzyme activity to NMDA dysfunction and schizophrenia. Thus, it is feasible to employ DAO inhibitors for the treatment of schizophrenia and other indications. Powered by the Schrödinger computational modeling platform, we initiated a research program to identify novel DAO inhibitors with the best-in-class properties. The program execution leveraged an hDAO FEP+ model to prospectively predict compound potency. A new class of DAO inhibitors with desirable properties has been discovered from this endeavor. Our modeling technol. on this program has not only enhanced the efficiency of structure-activity relationship development but also helped to identify a previously unexplored subpocket for further optimization. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Electric Literature of C8H6BrFO2).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Efficient and Regioselective Synthesis of Phenothiazine via Ferric Citrate Catalyzed C-S/C-N Cross-Coupling was written by Das, Tonmoy Chitta;Imam Quadri, Syed Aziz;Farooqui, Mazahar. And the article was included in Letters in Organic Chemistry in 2019.SDS of cas: 82702-31-6 This article mentions the following:

Efficient C-S and C-N cross-coupling reactions have been developed for regioselective, scalable and environmentally benign synthesis of substituted phenothiazine derivatives I (R = H, CN, COOMe, CONH₂, Cl, COOH, Br, CF₃). Cross-coupling reactions were demonstrated on various challenging substrates using non-toxic, highly economical, readily available ferric citrate as a catalyst to get desired products I with high regioselectivity. Atom economy is the added advantage of this protocol since addnl. N-protection step before coupling and eventual deprotection of the same to obtain the desired product are not required. This is the first report on the use of inexpensive ferric citrate as a catalyst without involving any ligand for the synthesis of regioselectively substituted phenothiazines I. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6SDS of cas: 82702-31-6).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.SDS of cas: 82702-31-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Targeting the Heat Shock Protein 90 Dimer with Dimeric Inhibitors was written by Kusuma, Bhaskar Reddy;Peterson, Laura B.;Zhao, Huiping;Vielhauer, George;Holzbeierlein, Jeffrey;Blagg, Brian S. J.. And the article was included in Journal of Medicinal Chemistry in 2011.Safety of Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

The design, synthesis, and biol. evaluation of conformationally constrained coumermycin A1 analogs are reported. Compounds were evaluated against both breast cancer (SKBr3 and MCF7) and prostate cancer (PC3 mm2, A549, and HT29) cell lines. Non-noviosylated coumermycin A1 analogs that manifest potent antiproliferative activity resulting from Hsp90 inhibition are provided, wherein replacement of the stereochem. complex noviose sugar with readily available piperidine rings resulted in ∼ 100 fold increase in antiproliferative activities as compared to coumermycin A1, producing small mol. Hsp90 inhibitors that exhibit nanomolar activities. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Safety of Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities was written by Cioffi, Christopher L.;Muthuraman, Parthasarathy;Raja, Arun;Varadi, Andras;Racz, Boglarka;Petrukhin, Konstantin. And the article was included in Journal of Medicinal Chemistry in 2020.Application In Synthesis of Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

Accumulation of cytotoxic lipofuscin bisretinoids may contribute to atrophic age-related macular degeneration (AMD) pathogenesis. Retinal bisretinoid synthesis depends on the influx of serum all-trans-retinol delivered via a tertiary retinol binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex. We previously identified selective RBP4 antagonists that dissociate circulating RBP4-TTR-retinol complexes, reduce serum RBP4 levels, and inhibit bisretinoid synthesis in models of enhanced retinal lipofuscinogenesis. However, the release of TTR by selective RBP4 antagonists may be associated with TTR tetramer destabilization and, potentially, TTR amyloid formation. We describe herein the identification of bispecific RBP4 antagonist-TTR tetramer kinetic stabilizers. Standout analog I possesses suitable potency for both targets, significantly lowers mouse plasma RBP4 levels, and prevents TTR aggregation in a gel-based assay. This new class of bispecific compounds may be especially important as a therapy for dry AMD patients who have another common age-related comorbidity, senile systemic amyloidosis, a nongenetic disease associated with wild-type TTR misfolding. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Application In Synthesis of Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application In Synthesis of Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary