Category: 82702-31-6

Kusuma, Bhaskar Reddy et al. published their research in Journal of Medicinal Chemistry in 2011 | CAS: 82702-31-6

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of Methyl 3-bromo-4-fluorobenzoate

Targeting the Heat Shock Protein 90 Dimer with Dimeric Inhibitors was written by Kusuma, Bhaskar Reddy;Peterson, Laura B.;Zhao, Huiping;Vielhauer, George;Holzbeierlein, Jeffrey;Blagg, Brian S. J.. And the article was included in Journal of Medicinal Chemistry in 2011.Safety of Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

The design, synthesis, and biol. evaluation of conformationally constrained coumermycin A1 analogs are reported. Compounds were evaluated against both breast cancer (SKBr3 and MCF7) and prostate cancer (PC3 mm2, A549, and HT29) cell lines. Non-noviosylated coumermycin A1 analogs that manifest potent antiproliferative activity resulting from Hsp90 inhibition are provided, wherein replacement of the stereochem. complex noviose sugar with readily available piperidine rings resulted in 闂?100 fold increase in antiproliferative activities as compared to coumermycin A1, producing small mol. Hsp90 inhibitors that exhibit nanomolar activities. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Safety of Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bonnefous, Celine et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2005 | CAS: 82702-31-6

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 82702-31-6

Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor was written by Bonnefous, Celine;Vernier, Jean-Michel;Hutchinson, John H.;Gardner, Michael F.;Cramer, Merryl;James, Joyce K.;Rowe, Blake A.;Daggett, Lorrie P.;Schaffhauser, Herve;Kamenecka, Theodore M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Reference of 82702-31-6 This article mentions the following:

A series of biphenyl-carboxylic acid indanones as allosteric potentiators of the metabotropic glutamate receptor 2 was identified and synthesized. Structure-activity relationship studies directed toward improving the potency and the brain to plasma ratio of the initial lead led to the discovery of two compounds (EC50 = 111 and 5 nM, resp.). In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Reference of 82702-31-6).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 82702-31-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chawla, Gita et al. published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2012 | CAS: 82702-31-6

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Methyl 3-bromo-4-fluorobenzoate

Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives was written by Chawla, Gita;Kumar, Umesh;Bawa, Sandhya;Kumar, Jagdish. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2012.Safety of Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

Several 2,5-disubstituted-1,3,4-oxadiazoles and 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized and characterized by elemental analyses and spectral data. These compounds were screened for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities. Compound I showed excellent anti-inflammatory and remarkable analgesic activity with reduced ulcerogenic and lipid peroxidation activity when compared with ibuprofen. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Safety of Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ahmad, Saleem et al. published their research in Journal of Medicinal Chemistry in 2001 | CAS: 82702-31-6

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: Methyl 3-bromo-4-fluorobenzoate

Arylcyclopropanecarboxyl Guanidines as Novel, Potent, and Selective Inhibitors of the Sodium Hydrogen Exchanger Isoform-1 was written by Ahmad, Saleem;Doweyko, Lidia M.;Dugar, Sundeep;Grazier, Nyeemah;Ngu, Khehyong;Wu, Shung C.;Yost, Kenneth J.;Chen, Bang-Chi;Gougoutas, Jack Z.;DiMarco, John D.;Lan, Shih-Jung;Gavin, Brian J.;Chen, Alice Y.;Dorso, Charles R.;Serafino, Randy;Kirby, Mark;Atwal, Karnail S.. And the article was included in Journal of Medicinal Chemistry in 2001.Recommanded Product: Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

A novel series of arylcyclopropanecarboxyl guanidines was synthesized and evaluated for activity against the sodium hydrogen exchanger isoform-1 (NHE-1). In biol. assays conducted in an AP1 cell line expressing the human NHE-1 isoform, the starting cyclopropane (IC50 = 3.5 娓璏) shows inhibitory activity comparable to cariporide (IC50 = 3.4 娓璏). Structure-activity relationships are used to optimize the affinity of various acyl guanidines for NHE-1 by screening the effect of substituents at both aryl and cyclopropyl rings. It is demonstrated that introduction of appropriate hydrophobic groups at the Ph ring and a gem-di-Me group at the cyclopropane ring enhances the NHE-1 inhibitory activity by up to 3 orders of magnitude (IC50 = 0.003 娓璏). In addition, the gem-di-Me series of analogs seem to display improved oral bioavailability and longer plasma half-life in rats. Furthermore, the lead benzodihydrofuranyl analog (BMS-284640) shows over 380-fold increased NHE-1 inhibitory activity as well as improved selectivity for NHE-1 over NHE-2 compared to cariporide. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Recommanded Product: Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Martin-Lopez, Juan et al. published their research in Pharmaceuticals in 2021 | CAS: 82702-31-6

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 82702-31-6

2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity was written by Martin-Lopez, Juan;Codony, Sandra;Bartra, Clara;Morisseau, Christophe;Loza, Maria Isabel;Sanfeliu, Coral;Hammock, Bruce D.;Brea, Jose;Vazquez, Santiago. And the article was included in Pharmaceuticals in 2021.HPLC of Formula: 82702-31-6 This article mentions the following:

The pharmacol. inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids. Numerous potent sEH inhibitors (sEHI) have been developed, however many contain highly lipophilic substituents limiting their availability. Recently, a new series of benzohomoadamantane-based ureas endowed with potent inhibitory activity for the human and murine sEH was reported. However, their very low microsomal stability prevented further development. Herein, a new series of benzohomoadamantane-based amides were synthesized, fully characterized, and evaluated as sEHI. Most of these amides were endowed with excellent inhibitory potencies. A selected compound displayed anti-inflammatory effects with higher effectiveness than the reference sEHI, TPPU. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6HPLC of Formula: 82702-31-6).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 82702-31-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tang, Haifeng et al. published their research in Journal of Medicinal Chemistry in 2022 | CAS: 82702-31-6

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C8H6BrFO2

Discovery of a Novel Class of D-Amino Acid Oxidase Inhibitors Using the Schr鏋歞inger Computational Platform was written by Tang, Haifeng;Jensen, Kristian;Houang, Evelyne;McRobb, Fiona M.;Bhat, Sathesh;Svensson, Mats;Bochevarov, Art;Day, Tyler;Dahlgren, Markus K.;Bell, Jeffery A.;Frye, Leah;Skene, Robert J.;Lewis, James H.;Osborne, James D.;Tierney, Jason P.;Gordon, James A.;Palomero, Maria A.;Gallati, Caroline;Chapman, Robert S. L.;Jones, Daniel R.;Hirst, Kim L.;Sephton, Mark;Chauhan, Alka;Sharpe, Andrew;Tardia, Piero;Dechaux, Elsa A.;Taylor, Andrea;Waddell, Ross D.;Valentine, Andrea;Janssens, Holden B.;Aziz, Omar;Bloomfield, Dawn E.;Ladha, Sandeep;Fraser, Ian J.;Ellard, John M.. And the article was included in Journal of Medicinal Chemistry in 2022.Electric Literature of C8H6BrFO2 This article mentions the following:

D-Serine is a coagonist of the N-Me D-aspartate (NMDA) receptor, a key excitatory neurotransmitter receptor. In the brain, D-serine is synthesized from its L-isomer by serine racemase and is metabolized by the D-amino acid oxidase (DAO, DAAO). Many studies have linked decreased D-serine concentration and/or increased DAO expression and enzyme activity to NMDA dysfunction and schizophrenia. Thus, it is feasible to employ DAO inhibitors for the treatment of schizophrenia and other indications. Powered by the Schr鏋歞inger computational modeling platform, we initiated a research program to identify novel DAO inhibitors with the best-in-class properties. The program execution leveraged an hDAO FEP+ model to prospectively predict compound potency. A new class of DAO inhibitors with desirable properties has been discovered from this endeavor. Our modeling technol. on this program has not only enhanced the efficiency of structure-activity relationship development but also helped to identify a previously unexplored subpocket for further optimization. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Electric Literature of C8H6BrFO2).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Das, Tonmoy Chitta et al. published their research in Letters in Organic Chemistry in 2019 | CAS: 82702-31-6

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.SDS of cas: 82702-31-6

Efficient and Regioselective Synthesis of Phenothiazine via Ferric Citrate Catalyzed C-S/C-N Cross-Coupling was written by Das, Tonmoy Chitta;Imam Quadri, Syed Aziz;Farooqui, Mazahar. And the article was included in Letters in Organic Chemistry in 2019.SDS of cas: 82702-31-6 This article mentions the following:

Efficient C-S and C-N cross-coupling reactions have been developed for regioselective, scalable and environmentally benign synthesis of substituted phenothiazine derivatives I (R = H, CN, COOMe, CONH2, Cl, COOH, Br, CF3). Cross-coupling reactions were demonstrated on various challenging substrates using non-toxic, highly economical, readily available ferric citrate as a catalyst to get desired products I with high regioselectivity. Atom economy is the added advantage of this protocol since addnl. N-protection step before coupling and eventual deprotection of the same to obtain the desired product are not required. This is the first report on the use of inexpensive ferric citrate as a catalyst without involving any ligand for the synthesis of regioselectively substituted phenothiazines I. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6SDS of cas: 82702-31-6).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.SDS of cas: 82702-31-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kusuma, Bhaskar Reddy et al. published their research in Journal of Medicinal Chemistry in 2011 | CAS: 82702-31-6

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of Methyl 3-bromo-4-fluorobenzoate

Targeting the Heat Shock Protein 90 Dimer with Dimeric Inhibitors was written by Kusuma, Bhaskar Reddy;Peterson, Laura B.;Zhao, Huiping;Vielhauer, George;Holzbeierlein, Jeffrey;Blagg, Brian S. J.. And the article was included in Journal of Medicinal Chemistry in 2011.Safety of Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

The design, synthesis, and biol. evaluation of conformationally constrained coumermycin A1 analogs are reported. Compounds were evaluated against both breast cancer (SKBr3 and MCF7) and prostate cancer (PC3 mm2, A549, and HT29) cell lines. Non-noviosylated coumermycin A1 analogs that manifest potent antiproliferative activity resulting from Hsp90 inhibition are provided, wherein replacement of the stereochem. complex noviose sugar with readily available piperidine rings resulted in 閳?100 fold increase in antiproliferative activities as compared to coumermycin A1, producing small mol. Hsp90 inhibitors that exhibit nanomolar activities. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Safety of Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bonnefous, Celine et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2005 | CAS: 82702-31-6

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 82702-31-6

Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor was written by Bonnefous, Celine;Vernier, Jean-Michel;Hutchinson, John H.;Gardner, Michael F.;Cramer, Merryl;James, Joyce K.;Rowe, Blake A.;Daggett, Lorrie P.;Schaffhauser, Herve;Kamenecka, Theodore M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Reference of 82702-31-6 This article mentions the following:

A series of biphenyl-carboxylic acid indanones as allosteric potentiators of the metabotropic glutamate receptor 2 was identified and synthesized. Structure-activity relationship studies directed toward improving the potency and the brain to plasma ratio of the initial lead led to the discovery of two compounds (EC50 = 111 and 5 nM, resp.). In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Reference of 82702-31-6).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 82702-31-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chawla, Gita et al. published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2012 | CAS: 82702-31-6

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Methyl 3-bromo-4-fluorobenzoate

Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives was written by Chawla, Gita;Kumar, Umesh;Bawa, Sandhya;Kumar, Jagdish. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2012.Safety of Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

Several 2,5-disubstituted-1,3,4-oxadiazoles and 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized and characterized by elemental analyses and spectral data. These compounds were screened for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities. Compound I showed excellent anti-inflammatory and remarkable analgesic activity with reduced ulcerogenic and lipid peroxidation activity when compared with ibuprofen. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Safety of Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary