Category: 82-73-5

Wang, Wei; Cha, Xue-Xiang; Reiner, John; Gao, Yuan; Qiao, Hai-Ling; Shen, Jia-Xiang; Chang, Jun-Biao published the artcile< Synthesis and biological activity of n-butylphthalide derivatives>, Computed Properties of 82-73-5, the main research area is butylphthalide derivative preparation vasorelaxant.

A series of n-butylphthalide derivatives were designed and synthesized. The in vitro activities of these compounds were evaluated by a resting tension of isolated rat thoracic aorta ring assay. Compounds I (R = F, Br) were found to be more active than n-butylphthalide.

European Journal of Medicinal Chemistry published new progress about Cardiovascular disease. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Butkevich, Alexey N. published the artcile< Modular Synthetic Approach to Silicon-Rhodamine Homologues and Analogues via Bis-aryllanthanum Reagents>, COA of Formula: C8H3BrO3, the main research area is silicon rhodamine homolog analog preparation modular fluorophore fluorescent label; regioselective double nucleophilic addition aryllanthanum ester anhydride lactone.

A modular synthetic approach toward diverse analogs of the far-red fluorophore silicon-rhodamine (SiR), based on a regioselective double nucleophilic addition of aryllanthanum reagents to esters, anhydrides, and lactones, is proposed. The reaction has improved functional group tolerance and represents a unified strategy toward cell-permeant, spontaneously blinking, and photoactivatable SiR fluorescent labels. In tandem with Pd-catalyzed hydroxy- or aminocarbonylation, it serves a streamlined synthetic pathway to a series of validated live-cell-compatible fluorescent dyes.

Organic Letters published new progress about Acidity. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, COA of Formula: C8H3BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rotbergs, J.; Cema, G.; Oskaja, V. published the artcile< Condensation dicarboxylic acid anhydrides with compounds containing active methylene groups. V. 3-Bromophthalic anhydride condensation with some β-dicarbonyl compounds>, Computed Properties of 82-73-5, the main research area is INDANS VIA PHTHALIC ANHYDRIDE; BENZALINDANS VIA PHTHALIC ANHYDRIDE.

Condensation of 4.54 g. 3-bromophthalic anhydride (I) with 2.6 g. Et acetoacetate in 10 g. Ac2O and 4 g. Et3N at room temperature and treatment on the following day with 20 g. ice and 10 ml. concentrated HCl yielded 5.1 g. product, which after dissolving in a mixture of 750 ml. hot H2O and 150 ml. concentrated HCl gave 2.5 g. 4-bromoindan-1,3-dione (II), decomposed 158-9°; dioxime decomposed 285°. Boiling a mixture of 0.44 g. II, 0.21 g. BzH, 10 ml. EtOH, and 0.05 ml. piperidine gave, after addition of 0.2 ml. AcOH, 0.6 g. 4-bromo-2-benzalindan-1,3-dione, m. 144-6° (EtOH). Similarly prepared was 78% 4-bromo-2-(p-nitrobenzal)indan-1,3-dione, m. 283-4° (AcOH). Reaction of 2.27 g. I with 1 g. Ac2CH2, 5 g. Ac2O, and 1 g. Et3N for 24 hrs. gave 0.82 g. III, m. 165-6° (MeOH). Similarly were prepared: 41% IV (with BzCH2Ac), m. 182-3° (EtOH); 53% V (with Bz2CH2), m. 186-7° (EtOAc); 66% VI (with di-Et malonate), m. 126-7° (MeOH). Unlike the condensation product of I with Et acetoacetate, III-VI are stable when refluxed with dilute HCl.

Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), RACT (Reactant or Reagent). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hassaballah, Aya I.; Ramadan, Sayed K.; Rizk, Sameh A.; El-Helw, Eman A. E.; Abdelwahab, Salwa S. published the artcile< Ultrasonic Promoted Regioselective Reactions of the Novel Spiro 3,1-Benzoxazon-Isobenzofuranone Dye Toward Some Organic Base Reagents>, Synthetic Route of 82-73-5, the main research area is spiro benzoxazinone isobenzofuranone nucleophile electrophile multicomponent reaction regioselective ultrasonic; antitumor antibacterial antifungal activity human green chem.

4′-Bromo-3′H-spiro[benzo[d][1,3]-oxazine-2,1′-isobenzofuran]-3′,4(1H)-dione dye is prepared via condensation of 2-aminobenzoic acid with 4-bromoisobenzofuran-1,3-dione under Ultrasonic, solvent-free and basic reaction conditions. The spiro product exhibited both electrophilic and nucleophilic centers. A series of nitrogen nucleophiles such as hydrazine, glycine, 2-aminopyridine, pyridin-2-ylmethanamine, 4-methoxyaniline, 4-aminoacetophenone, morpholine, piperidine or 1-ethylpiperazine and carbon electrophiles such as (chloromethyl)oxirane, Et chloroacetate, chloroacetyl chloride can be treated with 2-benzoxazine-2-yl benzoic acid (BBA) via multicomponent reaction. The fluorescence of the spiro product dyes decreases proportionally to the initial chloride concentration in the solution The chem. structures of the synthesized compounds can be confirmed by microanal., spectral data and optimized by quantum chem. parameters. Biol. evaluation showed that these synthesized spiro compounds exhibited moderate to good cytotoxic activity. Among them, compounds and displayed the best cytotoxic activity against MCF7 and Wl-38 cell lines.

Polycyclic Aromatic Compounds published new progress about Antibacterial agents. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Synthetic Route of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hanafi, Maha; Chen, Xinde; Neamati, Nouri published the artcile< Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is tumorigenesis oncogenic pathways PROTACs STAT3 E3 ligase cytotoxicity degrader.

Napabucasin, undergoing multiple clin. trials, was reported to inhibit the signal transducer and transcription factor 3 (STAT3). To better elucidate its mechanism of action, we designed a napabucasin-based proteolysis targeting chimera (PROTAC), XD2-149(I) that resulted in inhibition of STAT3 signaling in pancreatic cancer cell lines without inducing proteasome-dependent degradation of STAT3. Proteomics anal. of XD2-149 revealed the downregulation of the E3 ubiquitin-protein ligase ZFP91. XD2-149 degrades ZFP91 with DC50 values in the nanomolar range. The cytotoxicity of XD2-149 was significantly, but not fully, reduced with ZFP91 knockdown providing evidence for its multi-targeted mechanism of action. The NQO1 inhibitor, dicoumarol, rescued the cytotoxicity of XD2-149 but not ZFP91 degradation, suggesting that the NQO1-induced cell death is independent of ZFP91. ZFP91 plays a role in tumorigenesis and is involved in multiple oncogenic pathways including NF-κB and HIF-1α.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Sha; Zhou, Shaa; Xie, Yong-Tao; Jin, Ru-Yi; Meng, Xiang-De; Zhang, Dong-Kai; Hua, Xue-Wen; Liu, Ming; Wu, Chang-Chun; Xiong, Li-Xia; Zhao, Yu; Li, Zheng-Ming published the artcile< The exploration of chiral N-cyano sulfiliminyl dicarboxamides on insecticidal activities>, Computed Properties of 82-73-5, the main research area is chiral cyano sulfiliminyl dicarboxamide preparation insecticide Pseudaletia larva.

Due to new mechanism of action and ecofriendly characteristics, dicarboxamide insecticides have attracted more and more attentions in modern pest management. A series of 20 dual chiral N-cyano sulfilimines containing two centers (carbon and sulfur) were designed and synthesized. All title compounds were determined by 1H NMR, high-resolution mass spectrometry (HRMS) and optical polarimeter. The preliminary results indicated that some of them exhibited favorable insecticidal activities against oriental armyworm (Pseudaletia separata Walker). These isomers exhibited different impact on activity following the sequence as (Sc, Ss) ≥ (Sc, Rs), and the rule of title compounds’ activity against oriental armyworm was 3-CF3 ≥ 2-CH3-4-Cl >2, 3, 4-trifluro in the anilide moiety. The results indicated that these groups such as 3-CF3, 2-CH3-4-Cl or 2, 3, 4-trifluro were inefficient to replace heptafluoroisopropyl group for high larvicidal activity, which provided some guidance for the further modifications of sulfiliminyl dicarboxamides.

Chinese Chemical Letters published new progress about Insecticides. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Michael, William R.; King, William R.; Wakim, J. M. published the artcile< Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog, and monkey>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is etidronate disodium metabolism; absorption etidronate disodium.

After administration by intragastric cannula, the absorption of disodium etidronate [7414-83-7] (10-20 mg/kg) from the gastrointestinal tract of adult rats, weanling rats, rabbits, monkeys, adult dogs, and young dogs was 3, 10.5, 3.8, 6, 14, and 21% resp. Absorption was primarily from the stomach. I was not metabolized by the rat or dog, and there was virtually no enterohepatic circulation of I in the rat. Approx. half of the absorbed I was excreted in the urine, while the remaining half was deposited in the skeleton. The half-life of I the skeleton of the rat was 12 days.

Toxicology and Applied Pharmacology published new progress about Bone. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jow, Kenny G.; Dingemans, Theo J. published the artcile< Liquid crystals derived from 2-phenylisoindoles: synthesis and characterization>, Formula: C8H3BrO3, the main research area is phenylisoindole preparation smectic A liquid crystal.

2-Phenylisoindole was studied as the rigid core unit in asym. mesogenic mols. When the 2-phenylisoindole core was terminated with a hexyl tail, no mesophase formation could be observed When 4-(tridecafluorohexyl) was used, however, both monotropic and enantiotropic phase behavior were observed Most functionalities at the anhydride 5-position gave smectic A (SmA) phases in the temperature range 70-180°. Functionalities at the anhydride 4-position suppress mesophase formation. Large substituents (Br, NO2) and sym. substitution patterns (5,6-dichloro, 4,7-dichloro and 4,5,6,7-tetrachloro) on the anhydride moiety increase the m.p. and destabilize the mesophase. Temperature dependent x-ray diffraction experiments suggest an interdigitated SmA packing for this family of compounds

Liquid Crystals published new progress about Liquid crystal transition. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Formula: C8H3BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

El Sherbini, Ashraf M.; El Farash, Ahmed H.; El Sherbini, Tharwat M.; Parigger, Christian G. published the artcile< Opacity corrections for resonance silver lines in nano-material laser-induced plasma>, Category: bromides-buliding-blocks, the main research area is .

Q-switched laser radiation at wavelengths of 355, 532, and 1064 nm from a Nd: YAG laser was used to generate plasma in laboratory air at the target surface made of nano-silver particles of size 95 10 nm. The emitted resonance spectra from the neutral silver at wavelengths of 327.9 nm and 338.2 nm indicate existence of self-reversal in addition to plasma self-absorption. Both lines were identified in emission spectra at different laser irradiation wavelengths with characteristic dips at the un-shifted central wavelengths. These dips are usually associated with self-reversal. Under similar conditions, plasmas at the corresponding bulk silver target were generated. The recorded emission spectra were compared to those obtained from the nano-material target. The comparisons confirm existence of self-reversal of resonance lines that emerge from plasmas produced at nano-material targets. This work suggests a method for recovery of the spectral line shapes and discusses practical examples. In addition, subsidiary calibration efforts that utilize the Balmer series H-line reveal that other Ag I lines at 827.35 nm and 768.7 nm are optically thin under variety of exptl. conditions and are well-suited as reference lines for measurement of the laser plasma electron d.

Atoms published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Q B; Chang, L; Ye, F; Luo, Q H; Tao, Y X; Shu, H H published the artcile< Corrigendum to 'Role of spinal cyclooxygenase-2 and prostaglandin E2 in fentanyl-induced hyperalgesia in rats' (Br J Anaesth 2018; 120: 827-35).>, Product Details of C8H3BrO3, the main research area is .

There is no abstract available for this document.

British journal of anaesthesia published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Product Details of C8H3BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary