Category: 81216-14-0

Coombs, John R. published the artcileEnantiomerically Enriched Tris(boronates): Readily Accessible Conjunctive Reagents for Asymmetric Synthesis, SDS of cas: 81216-14-0, the publication is Journal of the American Chemical Society (2014), 136(46), 16140-16143, database is CAplus and MEDLINE.

The catalytic enantioselective diboration of vinyl boronate esters furnishes chiral tris(boronates) in a selective fashion. Subsequent deborylative alkylation occurs in a diastereoselective fashion, both for intermol. and intramol. processes.

Journal of the American Chemical Society published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, SDS of cas: 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Zi-Lu published the artcileCopper-Catalyzed Anti-Markovnikov Hydrosilylation of Terminal Alkynes, Safety of 7-Bromohept-1-yne, the publication is Organic Letters (2020), 22(19), 7735-7742, database is CAplus and MEDLINE.

A Cu-catalyzed anti-Markovnikov hydrosilylation of alkynes with PhSiH₃ is reported. This reaction represents a notable and efficient example on Cu-catalyzed hydrosilylation of alkynes, which shows excellent recognition between the terminal and internal triple bonds. Various (hetero)aromatic and aliphatic substituted terminal alkynes underwent this reaction to afford the (E)-vinylsilanes in high yields and with excellent regioselectivity.

Organic Letters published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C8H6ClF3, Safety of 7-Bromohept-1-yne.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Feng, Jian published the artcileCopper-Catalyzed 1,2,5-Trifunctionalization of Terminal Alkynes Using SR as a Transient Directing Group for Radical Translocation, Synthetic Route of 81216-14-0, the publication is Chinese Journal of Chemistry (2022), 40(14), 1667-1673, database is CAplus.

The first Cu-catalyzed 1,2,5-trifunctionalization of abundant terminal alkynes is realized by merging hydrogen atom transfer and traceless directing strategy with SR as a transient group, delivering highly functionalized aldehydes in moderate to excellent yields with broad substrate scope. The synthetic utility of this method was demonstrated by the gram-scale reaction and downstream transformations of the resultant products. Given the high efficient installation of three different functional groups in a single reaction, it can serve as a very attractive method for rapidly assembling complex mols. from readily available starting materials.

Chinese Journal of Chemistry published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Synthetic Route of 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tsuji, Hayato published the artcileIndium-catalyzed cycloisomerization of ψ-Alkynyl-β-keto esters into six- to fifteen-membered rings, Application In Synthesis of 81216-14-0, the publication is Angewandte Chemie, International Edition (2007), 46(42), 8060-8062, database is CAplus and MEDLINE.

Many different sizes of rings are made available via heating of ψ-alkynyl-β-keto esters in the presence of In(NTf₂)₃ (Tf = trifluoromethanesulfonyl). The products, produces six- to fifteen-membered ring compounds are produced in good yields. The reaction features low catalyst loading and moderately dilute conditions, and the formation of medium-sized rings is sometimes faster than that for the corresponding six-membered rings. Cycloisomerization of 3-oxo-16-heptadecynoic acid Me ester gave 2-methyl-15-oxo-1-cyclopentadecene-1-carboxylic acid Me ester. Reduction of the latter gave 2-methyl-15-oxo-1-cyclopentadecanecarboxylic acid Me ester. Decarboxylation of this intermediate gave (±)-muscone (i.e., 3-methylcyclopentadecanone).

Angewandte Chemie, International Edition published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C18H10F3NO3S2, Application In Synthesis of 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Newman, Melvin S. published the artcileThe preparation of the six n-octynoic acids, Recommanded Product: 7-Bromohept-1-yne, the publication is Journal of the American Chemical Society (1949), 1292-7, database is CAplus and MEDLINE.

A study was desired of the reactivity of the acetylenic bond at varying distances from the CO₂H group, also of various methods of synthesis and of the odors of the Me esters. Cl(CH₂)₄Br (I), prepared in 62% yield by passing HCl gas into AlCl₃ 1, H₂O 3, and THF 720 g. above 105°, adding the mixture at room temperature to 2 kg. PBr₃ with ice cooling, heating 1 h. on the steam bath, and separating the upper layer, b₃₀ 80-2°. Distillation of 329 g. Cl(CH₂)₅OAc, 320g. MeOH, and 5 g. p-MeC₆H₄SO₃H gave 180 g. MeOH-MeOAc azeotrope, b. 54°, and then concentration in vacuo at room temperature and addition of 271 g. PBr₃, etc., gave 325 g. (88%) Cl(CH₂)₅Br (II), b₂₀ 92-3°, n_D²⁵ 1.4815. Preparation of acetylenic alcs.: 1-Hexyne 1 in dry Et₂O was added slowly to 1.1 mol EtMgBr in Et₂O, and after 6 h. refluxing under N, 1 equivalent CH₂O was added (from a N stream over dry paraformaldehyde at 180°) under reflux to give 82% 2-heptyn-1-ol (III), b₅₆ 113-16°. Similarly 2-hexyn-1-ol (IV), in 71% yield from 1-pentyne, b₅₈ 87-9°; 3,5-dinitrobenzoate, in high yield, m. 64-5°. 3-Hexyn-1-ol, 48% from 1-butynylsodium and ethylene oxide in liquid NH₃, b. 161°; dinitrobenzoate, m. 72-3°. 3-Heptyn-1-ol (V) was similarly prepared in 45% yield, and 3-octyn-1-ol (VI), 37% yield, b₂₅ 105-6°. 4-, 5-, and 6-Heptyn-1-ol were prepared from the chloroalkynes via the iodides to the acetates with KOAc in boiling absolute EtOH, hydrolysis, conversion of the alcs. to benzoates, distillation, and saponification (see table). Preparation of 1-chloroacetylenes: addition of 5 mol of I to 5 mol Na₂C₂ in 3 l. liquid NH₃ during 4 h., 7 h. refluxing, evaporation of most of the NH₃ during 8 h., slow addition of 2 l. H₂O, Et₂O extraction, and distillation gave 74% 1-chloro-5-hexyne (VII), b. 143-4°. Similarly 1-chloro-6-heptyne (VIII) was prepared in 70% yield from Na₂C₂ and II, 73% 1-chloro-5-heptyne (IX) from NaCCMe and I, and 1-chloro-4-heptyne (X) in 30% yield (addition of NaCCEt to Cl (CH₂)₃Br gave no better yield). This type of reaction did not work with Cl(CH₂)₂Br. As IX and X were impure, another method was tried. NaNH₂ (78 g.) was stirred 30 min. with 205 g. 1-chloro-4-pentyne in 2 l. liquid NH₃, and then 218 g. EtBr added during 3 h.; distillation gave 17% (45 g.) crude X containing traces of a terminal alkyne, possibly VIII. Addition of HgI₂ reagent (Johnson and McEwen, C.A. 20, 1054), filtration from a white product m. 66-7°, precipitation of the excess reagent with 1-hexyne, and distillation gave pure X. Similarly 1-chloro-5-hexyne and NaNH₂, then MeBr, gave 38% crude IX, converted to 19% pure IX and a Hg derivative m. 76-7°. 1-Chloro-3-heptyne, prepared in 38% yield by the method of Johnson (C.A. 32, 7425.9) or in 72% yield from SOCl₂, C₅H₅N, and V by the procedure below, b₃₀ 71-5°, b₇₀ 90-3°. Addition of III (112 g.) and 78 g. C₅H₅N in dry Et₂O added to 131 g. SOCl₂ in Et₂O at reflux rate, evaporation of the Et₂O to a residue temperature of 80°, addition of 13 g. SOCl₂, 1 h. refluxing, and washing with Na₂CO₃ solution gave 77% 1-chloro-2-heptyne (XI), b₂₄ 73°. Preparation of 1-bromoacetylenes: III (310 g.) and 5 g. C₅H₅N in Et₂O added to 271 g. PBr₃ at reflux rate, the mixture heated 2 h., the upper cooled layer poured onto ice, and the Et₂O extract washed with aqueous Na₂CO₃ and distilled gave 72% 1-bromo-2-heptyne (XII), b₅₆ 104-5°, and 7% of presumably 1,3-dibromo-2-heptene, b₂₅ 112°, b₂ 70°, n_D²⁵ 1.5172. No XII was obtained when 1 equivalent C₅H₅N was used. Similarly IV gave 63% 1-bromo-2-hexyne (XIII), b₈₀ 97-8°, n_D²⁵ 1.4884, and also 12% HBr addn, product, probably 1,3-dibromo-2-hexene, b₂₅ 100°, b₂ 62°, n_D²⁵ 1.5235. The yield of crude 1-bromo-3-heptyne from V was only 41%. Both Br compounds XII and XIII gave immediate precipitates with alc. AgNO₃ whereas the Cl compound XI reacted only slowly or on warming. Addition of 3.2 mol Na₂C₂ in 1.5 l. liquid NH₃ during 1 h. to 1050 g. Br(CH₂)₅Br, 500 cc. Et₂O, and 1000 cc. NH₃, then 2 h. stirring, etc., gave 27% 1-bromo-6-heptyne (XIV), b₂₀ 92°, n_D²⁵ 1.4750. Because of difficulties in the conversion of XII to the nitrile, N. and W. considered the addition of Br to the triple bond and its later removal; they did add 80 g. Br to 56 g. III in CCl₄ at 0° to obtain 81% 2,3-dibromo-2-hepten-1-ol (XV), b₄ 113-15°; 3,5-dinitrobenzoate, m. 84-5°. XV was then converted to 87% 1,2,3-tribromo-2-heptene, b₄ 112-14°, b₂ 96°, n_D²⁵ 1.5540. Similarly VI gave 3,4-dibromo-3-octen-1-ol, b₂ 111-13°; 3,5-dinitrobenzoate, m. 85-6°. Crude VII and excess NaI in boiling Me₂CO for 20 h. gave 82% 1-iodo-5-hexyne, b₃₅ 94-5°, n_D²⁵ 1.5286. Preparation of acetylenic nitriles: XIV (120 g.), 65 g. KCN, 120 cc. H₂O, and 300 cc. Me₂CO were refluxed 48 h., 250 cc. mixed solvent distilled, etc., to give 74% 1-cyano-6-heptyne, b₆ 90-2°. Similarly 1-cyano-5-heptyne, b₅ 88-95°, was prepared in 75% yield from the 1-chloro via the 1-iodo derivative, and 1-chloro-4-heptyne was directly converted to 82% 1-cyano-4-heptyne, b₂₉ 110-12°. XII (70 g.), 45 g. Cu₂(CN)₂ (carefully dried), and 40 cc. xylene were heated to 157°, then the bath temperature lowered to 145°, and the exothermic reaction allowed to proceed 30 min. below 165°; C₆H₆ extraction of the cooled mixture and distillation gave 92% 1-cyano-2-heptyne (XVI), b₅₆ 123-6°. Other yields were 0-90%, careful temperature control being very important. XII or XI and aqueous KCN would not give XVI. 1-Cyano-3-heptyne (XVII) was prepared in 50% yield from the acid via the amide and dehydration of the latter with P₂O₅. Acetylenic acids: Except for XVII, the nitriles were hydrolyzed in boiling aqueous alc. 10% KOH until NH₃ evolution ceased. Data are given in the table, 5-, 6-, and 7-octynoic acids being prepared in 90% yields. 3-Octynoic acid, prepared in 74% yield by addition of HCl gas to 140 g. XVI in 250 cc. MeOH and 25 cc. H₂O until the mixture refluxed, then the temperature allowed to drop to 30°, concentration of the filtrate, and saponification of the crude ester with alc. alkali, b₆ 120-30°. XVI (6 g.) and 20 cc. concentrated HCl, 4 days at room temperature gave 3 g. product, crystallized from ligroin (b. 30-60°), presumably 4-chloro-3-octenamide, m. 54-5°, whereas XVI and concentrated HCl at 80° 12 h. gave the acid (46%), b₃ 125-6°. XVI (6 g.), 5 g. H₂SO₄, and 2 g. H₂O were heated 2 days at 60°, 10 cc. 6 N H₂SO₄ added with 1 day heating, the organic material isolated and heated with aqueous KOH to give a solution, and the acid product distilled and crystallized from ligroin to give 4 g. 4-ketoöctanoic acid, m. 53-4°. XVI was brominated as XV above to 50% 1-cyano-2,3-dibromo-2-heptene, b₄ 118°. Hydrolysis of 14 g. with 20 cc. concentrated H₂SO₄ 15 min. at 80°, then 3 h. at room temperature, gave only 47% 3,4-dibromo-3-octenamide. m. 130-1°. 4- (XVIII) and 5-Octynoic acids were prepared by decarboxylation of the corresponding malonic esters. Thus, 280 g. XIII added to 41.5 g. Na and 320 g. Et malonate in 1.5 l. EtOH, then 8 h. refluxing, etc., gave 57% Et 2-hexynylmalonate (XIX), b₅ 134-5°, and 13% Et di(2-hexynyl)malonate, b₅ 168-70°, n_D²⁵ 1.4600, and saponification gave the resp. acids, m. 109-10° and 138-9° (decomposition). New Acetylenic Compounds; ROH, DNB*, RCOOH, RCONH₂, RCl, RBr, RCN, Me ester; B.p., M.p., b₂, M.p., M.p., b₇₆₀, B.p., B.p.; R, °C., mm., n_D²⁵, °C., °C., °C., n_D²⁵, °C., °C., n_D²⁵, °C., mm., n_D²⁵, °C., mm., n_D²⁵, b₂, n_D²⁵; HCC(CH₂)₅, 98, 20, 1.4534, 46, 123, 20, 1.4502, 86, 166, 1.4507, 92, 20, 1.4750, 80, 3, 1.4460, 64, 1.4380; MeCC(CH₂)₄, 96, 15, 1.4590, 53, 116, 37, …, 113, 175, 1.4599, …, .., …, 79, 2, 1.4530, 68, 1.4433; EtCC(CH₂)₃, 91, 15, 1.4593, 52, 111, 8, 1.4540, 105, 164, 1.4540, …, .., …, 111, 29, 1.4514, 64, 1.4421; PrCC(CH₂)₂, 111, 70, 1.4530, 61, 121, 49, …, 118, 162, 1.4520, 100, 65, 1.4785, 71, 3, 1.4492, 63, 1.4414; BuCCCH₂, 98, 28, 1.4523, 62, 110, 18, 1.4577, 52, 167, 1.4570, 84, 20, 1.4878, 124, 56, 1.4475, 64, 1.4448; AmCC, …, .., …, .., 114, 5, 1.4588, 91, …, …, 69, 25, 1.4678, 86, 17, 1.4551, 70, 1.4442; * Dinitrobenzoate ester of ROH. Heating XIX at 150-70° until CO₂ evolution ceased gave 93% XVIII. In 1 preparation of XIX, a small amount of Et di(2-hexynyl)acetate, b₃ 135-7°, was isolated, and converted to the amide, m. 63-4°. Et 2-heptynylmalonate, prepared as XIX above in 66% yield, b₅ 146°, and the free acid, m. 93-4°. The Me esters were prepared in 90% yields by refluxing the acids with excess MeOH and small amounts of p-MeC₆H₄SO₃H 12 h. The odors of the Me octynoates were evaluated by men skilled in the art: 7-, very green but sharp, chem., fatty, unpleasant; 6-, reseda-like, fatty, weak, green seaweed; 5-, leafy, cucumberlike, something like talia, sweet, violet; 4-, cucumberlike but sharp, chem., somewhat fruity; 3-, something like fresh-cut grass, but crude and fatty. Ozonization in HOAc of the octynoic acids gave the following dibasic acids: 7-, 46% pimelic; 6-, 52% adipic; 5-, 71% glutaric; 4-, 67% succinic, and 3-, 80% malonic acid. Hydrogenation of 0.8-1.4 g. octynoic acid in 20 cc. pure EtOH with 0.2 g. Adams Pt catalyst (cf. Joshel, C.A. 37, 6162.4) 150-300 min. gave in each case n-octanoic acid, m. p. and mixed m. p. of amide 103-4°.

Journal of the American Chemical Society published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Recommanded Product: 7-Bromohept-1-yne.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gerken, Philip A. published the artcileDiscovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7, Application In Synthesis of 81216-14-0, the publication is Angewandte Chemie, International Edition (2017), 56(49), 15555-15559, database is CAplus and MEDLINE.

Histone lysine demethylases (KDMs) are of critical importance in the epigenetic regulation of gene expression, yet there are few selective, cell-permeable inhibitors or suitable tool compounds for these enzymes. The authors describe the discovery of a new class of inhibitor that is highly potent towards the histone lysine demethylases KDM2A/7A. A modular synthetic approach was used to explore the chem. space and accelerate the investigation of key structure-activity relationships, leading to the development of a small mol. with around 75-fold selectivity towards KDM2A/7A vs. other KDMs, as well as cellular activity at low micromolar concentrations

Angewandte Chemie, International Edition published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Application In Synthesis of 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chen, Junfeng published the artcileEnzyme-like Click Catalysis by a Copper-Containing Single-Chain Nanoparticle, HPLC of Formula: 81216-14-0, the publication is Journal of the American Chemical Society (2018), 140(42), 13695-13702, database is CAplus and MEDLINE.

A major challenge in performing reactions in biol. systems is the requirement for low substrate concentrations, often in the micromolar range. We report that copper cross-linked single-chain nanoparticles (SCNPs) are able to significantly increase the efficiency of copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reactions at low substrate concentration in aqueous buffer by promoting substrate binding. Using a fluorogenic click reaction and dye uptake experiments, a structure-activity study is performed with SCNPs of different size and copper content and substrates of varying charge and hydrophobicity. The high catalytic efficiency and selectivity are attributed to a mechanism that involves an enzyme-like substrate binding process. Saturation-transfer difference (STD) NMR spectroscopy, 2D-NOESY NMR, kinetic analyses with varying substrate concentrations, and computational simulations are consistent with a Michaelis-Menten, two-substrate, random-sequential enzyme-like kinetic profile. This general approach may prove useful for developing more-sustainable catalysts and agents for biomedicine and chem. biol.

Journal of the American Chemical Society published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, HPLC of Formula: 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Eubanks, Lisa M. published the artcileIdentification of α₂ Macroglobulin as a Major Serum Ghrelin Esterase, Application of 7-Bromohept-1-yne, the publication is Angewandte Chemie, International Edition (2011), 50(45), 10699-10702, S10699/1-S10699/23, database is CAplus and MEDLINE.

Ghrelin is an appetite-stimulating hormone secreted from endocrine cells in the stomach. Ghrelin is synthesized as a 117-residue polypeptide (preproghrelin) which undergoes proteolytic cleavage to produce the 94-residue proghrelin. Subsequent post-translational processing events include cleavage of proghrelin at residue Arg28 and octanoylation at the hydroxyl group of Ser3; these modifications generate the mature 28-residue ghrelin peptide. In serum, the inactivation of ghrelin is thought to occur primarily by deacylation of Ser3. In order to capture serum-based serine hydrolase enzymes that participate in the deacylation of circulating ghrelin, the present work describes the synthesis of a ghrelin-like “bait” mol. (probe 1) that contains a phosphonofluoridate warhead. The interaction of probe 1 with α₂-macroglobulin (α₂M) lead to addnl. studies which indicate that α₂M possesses ghrelin esterase activity and plays an important role in ghrelin metabolism

Angewandte Chemie, International Edition published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Application of 7-Bromohept-1-yne.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Okuda, Yasuhiro published the artcileIntramolecular cyclization mediated by silylmetalation of acetylenes with dimethylphenylsilylmethylmagnesium (PhMe₂SiMgMe)/cuprous iodide and radical nature of the reagent, Computed Properties of 81216-14-0, the publication is Tetrahedron Letters (1984), 25(23), 2483-6, database is CAplus.

HCC(CH₂)₃XR (X = bond, CH₂, CHMe, CHBu,CH₂CH₂; R = O₃SC₆H₄Me-4, O₃SMe, Br) underwent CuI-catalyzed reaction with Me₂SiPhMgMe to give 25-91% methylenylcycloalkanes I. However, the same treatment of HCCCH₂CHR¹O₃SMe (R¹ = H, Me) gave 30-45% methylenecyclopropanes II and 10-41% silylcyclobutenes III.

Tetrahedron Letters published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Computed Properties of 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wotiz, John H. published the artcileThe infrared spectra of a number of isomeric normal acetylenic compounds, Product Details of C7H11Br, the publication is Journal of the American Chemical Society (1949), 3441-4, database is CAplus.

The infrared spectra of 28 normal acetylenic compounds and four substituted normal heptanes, C₅H₁₁CCH, C₄H₉CCCH₃, C₃H₇CC₂H₅, CH₆CC(CH₂)₄C, C₂H₅CC(CH₂)₃Cl, C₄H₉CCCH₂C, CH₃(CH₂)₆Br, HCC(CH₂)₅Br, CH₃CC(CH₂)₄Br, C₃H₇CC(CH₂)₂Br, C₄H₉CCCH₂Br, C₅H₁₁CCBr, CH₃(CH₂)₆OH, HCC(CH₂)₅OH, CH₃CC(CH₂)₄OH, C₂H₅CC(CH₂)₃OH, C₃H₇CC(CH₂)₂OH, C₄H₉CCCH₂OH, CH₃(CH₂)₆CN₂ HCC(CH₂)₅CN, CH₃CC(CH₂)₄CN, C₂H₅CC(CH₂)₃CN, C₃H₇CC(CH₂)₂CN, C₄H₉CCCH₂CN, C₅H₁₁CCCN, CH₃ (CH₂)₆CO₂CH₃, HCC(CH₂)₅CO₂CH₃, CH₃, C(CH₂)₄CO₂CH₃, C₂H₅CC(CH₂)₃CO₂CH₃, C₃H₇CC(CH₂)₂CO₂CH₃, C₄H₉CCCH₂CO₂CH₃, C₅H₁₁CCCO₂CH₃ are presented. The intensity of the CC band is observed to vary greatly. The band is most intense when the triple bond is near the end of the chain. If the triple bond is three or more positions from the end, the band is scarcely detectable.

Journal of the American Chemical Society published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C6H13BO3, Product Details of C7H11Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary