Category: 811711-33-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 811711-33-8, name is 1,2-Dibromo-3-fluorobenzene, A new synthetic method of this compound is introduced below., Formula: C6H3Br2F

In a nitrogen atmosphere, a flask containing 114 7-(diphenylamino)-9,9?-dimethyl-9H-fluoren-3-ol (9.0 g), 153 1,2-bromo-3-fluorobenzene (7.9 g), 77 potassium carbonate (8.2 g), and NMP (45 ml) was heated and stirred at a reflux temperature for two hours. After the reaction was stopped, the reaction liquid was cooled to room temperature, and 30 water was added thereto. A precipitate thus precipitated was collected by suction filtration. The obtained precipitate was washed with water and then with Solmix and then purified by silica gel column chromatography (eluent: heptane/toluene=3/1 (volume ratio)) to obtain 12.4 g of 154 6-(2,3-dibromophenoxy)-9,9-dimethyl-N,N-diphenyl-9H-fluoren-2-amine (yield: 84.8%).

The synthetic route of 811711-33-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JNC CORPORATION; FUJITA, Yukihiro; (228 pag.)US2019/165279; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 811711-33-8, name is 1,2-Dibromo-3-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 811711-33-8

A mixture of 2.5 g (12.23 mmol) of 7,8-difluoro-2-methylquinolin-3-amine and 3.32 g (12.84 mmol) of 1 ,2- dibromo-3-fluorobenzene together with 11.95 mg (36.69 mmol) of cesium carbonate and 708 mg (1.22 mmol) of 9,9-dimethyl-9H-xanthene-4,5-diyl)bis-(diphenylphosphane [Xantphos] in 70 mL of 1 ,4-dioxane was degassed with argon for 30 minutes. 896 mg (0.97 mmol) of tris(dibenzylideneacetone)pailadium(0) was added and the reaction mixture was heated at reflux for 26 hours. The cooled reaction mixture was filtered over a silica gel pad, and the pad washed by ethyl acetate. The organic phase was concentrated under vacuo and purified by column chromatography on silica gel (300 g cartridge – gradient n-heptane/ethyl acetate) to yield 2.31 g (49%) of N-(2-bromo-3-fluorophenyl)-7,8-difluoro-2-methylquinolin-3-amine. LogP = 3.28. Mass (M+H) = 367

According to the analysis of related databases, 811711-33-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; CRISTAU, Pierre; DESBORDES, Philippe; DUFOUR, Jeremy; GOURGUES, Mathieu; LAMPRECHT, Sybille; LOQUE, Dominique; MEISSNER, Ruth; NAUD, Sebastien; THOMAS, Vincent; (90 pag.)WO2020/79173; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary