Category: 81107-97-3

Cheng, Hua; Yang, Lu; Liu, Hong-Fu; Zhang, Rui; Chen, Cheng; Wu, Yuan; Jiang, Wen published the artcile< N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)picolinamide as a new inhibitor of mitochondrial complex III: Synthesis, biological evaluation and computational simulations>, Application In Synthesis of 81107-97-3, the main research area is chlorotrifluoromethylphenoxyphenylpicolinamide preparation mitochondria complex III inhibitor; Amide; Biological evaluation; Computational simulation; Diaryl ether; Inhibitor; Mitochondrial complex III.

Mitochondrial complex III is one of the most promising targets for a number of pharmaceuticals and fungicides. Due to the wide-spread use of complex III-inhibiting fungicides, a considerable increase of resistance occurred worldwide. Therefore, inhibitors with novel scaffolds and potent activity against complex III are still in great demand. A new series of amide compounds bearing the diaryl ether scaffold were designed and prepared, followed by the biol. evaluation. Gratifyingly, several compounds demonstrated potent activity against succinate-cytochrome c reductase (SCR, a mixture of mitochondrial complex II and complex III), with compound N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)picolinamide possessing the best inhibitory activity (IC50 = 0.91 ± 0.09μmol/L). Addnl. studies verified that N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)picolinamide was a new inhibitor of complex III. Moreover, computational simulations elucidated that N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)picolinamide should bind to the Qo site of complex III. The authors believe this work will be valuable for the preparation and discovery of more complex III inhibitors.

Bioorganic & Medicinal Chemistry Letters published new progress about 81107-97-3. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Application In Synthesis of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tietze, Lutz F.; Hungerland, Tim; Duefert, Alexander; Objartel, Ina; Stalke, Dietmar published the artcile< Synthesis of tetrasubstituted alkenes through a palladium-catalyzed domino carbopalladation/C-H-activation reaction>, Name: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is helical tetrasubstituted alkene preparation; propargylic alc preparation domino carbopalladation bond activation.

Helical tetrasubstituted alkenes, e.g., I, were obtained in a highly efficient way through a palladium-catalyzed domino-carbopalladation/C-H-activation reaction of propargylic alcs., e.g., II, in good to excellent yields. Electron-withdrawing- and electron-donating substituents can be introduced onto the upper and lower aromatic rings. The substrates for the domino process were synthesized by addition of the lithiated alkyne to various aldehydes; moreover, the substrates were accessible enantioselectively (in 95 % ee) by reduction of the corresponding ketone using the Noyori procedure.

Chemistry – A European Journal published new progress about Alcohols, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Name: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Boudreau, Marc A.; Ding, Derong; Meisel, Jayda E.; Janardhanan, Jeshina; Spink, Edward; Peng, Zhihong; Qian, Yuanyuan; Yamaguchi, Takao; Testero, Sebastian A.; O’Daniel, Peter I.; Leemans, Erika; Lastochkin, Elena; Song, Wei; Schroeder, Valerie A.; Wolter, William R.; Suckow, Mark A.; Mobashery, Shahriar; Chang, Mayland published the artcile< Structure-Activity Relationship for the Oxadiazole Class of Antibacterials>, Safety of 2-Bromo-4-(trifluoromethyl)phenol, the main research area is structure preparation oxadiazole derivative antibacterial.

A structure-activity relationship (SAR) for the oxadiazole class of antibacterials was evaluated by syntheses of 72 analogs and determination of the minimal-inhibitory concentrations (MICs) against the ESKAPE panel of bacteria. Selected compounds were further evaluated for in vitro toxicity, plasma protein binding, pharmacokinetics (PK), and a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) infection. Oxadiazole 72c shows potent in vitro antibacterial activity, exhibits low clearance, a high volume of distribution, and 41% oral bioavailability, and shows efficacy in mouse models of MRSA infection.

ACS Medicinal Chemistry Letters published new progress about Antibacterial agent resistance. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Safety of 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Riley, Robert D.; Huchenski, Blake S. N.; Bamford, Karlee L.; Speed, Alexander W. H. published the artcile< Diazaphospholene-Catalyzed Radical Reactions from Aryl Halides>, Reference of 81107-97-3, the main research area is heterocyclic compound preparation photochem; aryl halide radical cyclization diazaphospholene catalyst; Catalysis; Diazaphospholene; Heterocycles; Photochemistry; Radical Addition.

Herein, stoichiometric radical cyclizations of aryl iodides such as 1-iodo-2-[(3-phenylprop-2-en-1-yl)oxy]benzene and 1-iodo-2-[(3-methylbut-2-en-1-yl)oxy]benzene mediated by diazaphospholene hydrides are made catalytic by the combination of phenylsilane and alkali metal salts to regenerate the diazaphospholene hydride. The scope was expanded to include aryl bromides 2-Br-3-R-4-R1-5-R2C6HXR3 (X = O, S; R = H; R1 = H, F, CN, CF3, C(O)OMe; RR1 = -CH=CH-CH=CH-; R2 = H, CF3; R3 = 3-phenylbut-2-en-1-yl, 3-methylbut-2-en-1-yl, 3-phenylprop-2-en-1-yl, etc.), which benefit from visible light irradiation Twenty one substrates underwent cyclization, including a dearomative cyclization. Extension to six intermol. radical hydroarylations with arenes, thiophenes, and a pyridine e.g., 2-iodobenzotrifluoride was also accomplished.

Angewandte Chemie, International Edition published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Reference of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Zhipeng; Yu, Yang; Huang, Fei; Yi, Xiangyan; Xu, Yao; He, Yide; Baell, Jonathan B.; Huang, He published the artcile< Catalytic O-H bond insertion reactions using surface modified sewage sludge as a catalyst>, Product Details of C7H4BrF3O, the main research area is diazoester phenol sewage sludge catalyst insertion reaction green chem; phenoxy acetate preparation antitumor antiinflammatory activity cytotoxicity.

The more economical and greener surface modified sewage sludge-derived carbonaceous materials (SW) treated by perchloric acid as a new catalyst for carbene insertion of α-aryl α-diazoacetates into O-H bonds of phenols with good yields and high functional group tolerance was reported. The scope of natural phenols with compelling biol. activity, and successfully afforded the O-H insertion and meta C-H functionalization products was explored. Their structures was confirmed by single-crystal X-ray crystallog. Furthermore, the bioactivities (anti-tumor and anti-inflammatory) of the majority of O-H insertion products were better than those of the natural phenols themselves. The IC50 values indicated that the remarkable compounds I [ R1 = phenyl; R2 = ethyl] (IC50 = 16.80μM) and I [R1 = phenyl; R2 = prop-2-en-1-yl] (IC50 = 16.48μM) had better inhibition for tumor cell A-549 than pos. control DDP (IC50 = 20.62μM). It should be noted that these transformations was provided a new strategy to derive natural products and discover new drugs.

Green Chemistry published new progress about Acetates Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Product Details of C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary