Category: 81107-97-3

Ahmad, Maha; Gaumont, Annie-Claude; Durandetti, Muriel; Maddaluno, Jacques published the artcile< Direct Syn Addition of Two Silicon Atoms to a CC Triple Bond by Si-Si Bond Activation: Access to Reactive Disilylated Olefins>, Related Products of 81107-97-3, the main research area is syn addition silicon carbon triple bond activation disilylated olefin; stereoselective disilylated heterocycle preparation; crystal structure mol silylalkenyl silicon oxygen heterocycle preparation; cyclization; disilane; heterocycles; palladium; vinylsilane.

A catalytic intramol. silapalladation of alkynes affords, in good yields and stereoselectively, syn-disilylated heterocycles of different chem. structure and size. When applied to silylethers, this reaction leads to vinylic silanols that undergo a rhodium-catalyzed addition to activated olefins, providing the oxa-Heck or oxa-Michael products, depending on the reaction conditions.

Angewandte Chemie, International Edition published new progress about Addition reaction, stereoselective. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Related Products of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Perez-Gomez, Marta; Herrera-Ramirez, Piedad; Bautista, Delia; Saura-Llamas, Isabel; Garcia-Lopez, Jose-Antonio published the artcile< Synthesis of Benzofused O- and N-Heterocycles through Cascade Carbopalladation/Cross-Alkylation of Alkynes Involving the C-C Cleavage of Cyclobutanols>, SDS of cas: 81107-97-3, the main research area is palladium catalyzed cascade carbopalladation alkylation alkyne cyclobutanol; benzofuranylvinyl palladium iodide complex preparation crystal structure; mol structure benzofuranylvinyl palladium iodide complex.

The authors report a Pd-catalyzed route to heterocycles bearing a tetrasubstituted alkene fragment. The authors’ approach merges the intramol. carbopalladation of tethered alkynes with an alkylation step produced by the C-C cleavage of cyclobutanol derivatives An alkenyl-Pd(II) intermediate was isolated and characterized by x-ray diffraction studies. The nature of the tethering alkynyl chain influences the E/Z stereochem. of the alkenyl fragment in the functionalized heterocycles.

Organometallics published new progress about Alkylation. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, SDS of cas: 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Wen-Tao; Lu, Zhuo-Qun; Zheng, Hanliang; Xue, Xiao-Song; Zhao, Dongbing published the artcile< Rhodium-Catalyzed 2-Arylphenol-Derived Six-Membered Silacyclization: Straightforward Access toward Dibenzooxasilines and Silicon-Containing Planar Chiral Metallocenes>, Electric Literature of 81107-97-3, the main research area is rhodium catalyst arylphenol silacyclization stereoselective; benzooxasiloline dibenzooxasiline silicon planar chiral metallocene preparation photophys property; crystal structure mol chiral ferrocene silyl cyclic preparation optimized.

The C/Si switch strategy has been regarded as a useful and efficient strategy for the discovery of drugs and materials. Thus, development of a methodol. to access diverse silacycles is of great significance and in great demand. Among these, C-H bond silylation provides a powerful and straightforward synthetic method to form diverse silacycles in an atom- and step-economical fashion. However, C-H bond silylation has not been used to access any six-membered silicon-bridged π-conjugated scaffolds and enantioselective six-membered C-H silylation has never been presented. Herein, we successfully accessed diverse six-membered π-conjugated dibenzooxasilines via C-H bond silylation and investigated their photophys. properties. Furthermore, we realized enantioselective six-membered C-H silylation to directly afford planar chiral metallocene oxasilolanes with high ee (up to 95% ee). We also demonstrated the synthetic usefulness of dibenzooxasilines and planar chiral metallocene-fused benzooxasilolines as valuable synthetic intermediates via diverse addnl. transformations. Moreover, six-membered silicon-bridged ladder π-conjugated systems were designed and rapidly constructed by using our methods. The “”isomerization”” and “”silicon”” effects on mol. geometries and photophys. properties were also evaluated in detail.

ACS Catalysis published new progress about Chirality. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Electric Literature of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mondragon, Alexander; Monsalvo, Ivan; Regla, Ignacio; Castillo, Ivan published the artcile< 2,4-Bis(fluorocarbon)-substituted phenols for high yield Newman-Kwart rearrangement reactions>, Synthetic Route of 81107-97-3, the main research area is thiocarbamate biphenyl trifluoromethyl preparation Newman Kwart thermal rearrangement hydrolysis; biphenylthiol trifluoromethyl preparation.

The Newman-Kwart thermal rearrangement of 2,4-disubstituted O-arylthiocarbamates I (R = Me, F3C, X = O, Z = S), prepared from the corresponding phenols, was reported. Clean conversion to the S-arylthiocarbamates I (R = Me, F3C, X = S, Z = O) in high yields was observed The rearrangement appears to be facilitated by the presence of electron-withdrawing substituents in the 2- and 4-positions of the aromatic ring.

Tetrahedron Letters published new progress about Carbamates Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (thio). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Synthetic Route of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Belokon’, Yuri N.; Davies, R. Gareth; Fuentes, Jose A.; North, Michael; Parsons, Teresa published the artcile< The influence of imine structure, catalyst structure and reaction conditions on the enantioselectivity of the alkylation of alanine methyl ester imines catalyzed by Cu(ch-salen)>, Application In Synthesis of 81107-97-3, the main research area is alaninate imine preparation stereoselective alkylation copper salen catalyst.

Systematic variation of the substrate structure has shown that the most effective substrates for Cu(ch-salen)-catalyzed asym. enolate alkylation reactions carried out under phase-transfer conditions are the p-chlorophenyl imines of amino esters. The other reaction parameters (solvent and stirring speed) have also been optimized. The introduction of substituents onto the aryl rings of the salen ligand was found not to have a beneficial effect on the enantioselectivity of the reaction.

Tetrahedron Letters published new progress about Alkylation catalysts. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Application In Synthesis of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Namba, Tomoya; Hayashi, Yoshihiro; Kawauchi, Susumu; Shibata, Yu; Tanaka, Ken published the artcile< Rhodium-Catalyzed Cascade Synthesis of Benzofuranylmethylidene-Benzoxasiloles: Elucidating Reaction Mechanism and Efficient Solid-State Fluorescence>, Category: bromides-buliding-blocks, the main research area is rhodium catalysis cascade cycloisomerization bisethynylphenolsilane; benzofuranylmethylidenebenzoxasilole preparation mol modeling solid state fluorescence; fluorescence; isomerization; organosilicon compounds; rearrangement; rhodium; solid-state structures.

A new synthetic route to highly fluorescent benzofuranylmethylidenebenzoxasiloles through cationic rhodium(I)/binap complex-catalyzed cascade cycloisomerization of bis(2-ethynylphenol)silanes has been developed involving 1,2-silicon and 1,3-carbon (alkyne) migrations followed by oxycyclization. The present synthesis requires only three steps, starting from com. available dichlorodiisopropylsilane, which is markedly shorter than our previous synthesis (eight steps starting from com. available chlorodiisopropylsilane). Theor. calculations elucidated the mechanism of the above cascade cycloisomerization. This reaction is initiated by the formation of a rhodium vinylidene not through direct 1,2-silicon migration but rather through an unprecedented stepwise 1,5-silicon migration followed by C-Si bond-forming cyclization from a dearomatized allenylrhodium complex. Subsequent 1,3-carbon (alkyne) migration leading to a η3-allenyl/propargyl-rhodium complex followed by oxycyclization through π-bond (alkyne) activation with the cationic rhodium(I) complex affords the benzofuranylmethylidenebenzoxasilole product, e.g. I. The structure-fluorescence property relationships of the thus obtained benzofuranylmethylidenebenzoxasiloles were investigated, which revealed that good fluorescence quantum yields were generated in the solution state (φF=69-87 %) by introduction of electron-donating alkyl and Ph groups on two phenoxy groups. In the powder state, 4-methyl- and 4-methoxy-phenoxy derivatives exhibited efficient blue fluorescence (φF=52 % and 46 %, resp.). Especially, the 4-methylphenoxy derivative was thermally stable, and exhibited strong narrow-band fluorescence in the film state (blue, φF=95 %) and red shifted strong narrow-band fluorescence (green, φF=90 %) in the crystalline state as a result of the formation of an offset π-stacked dimer; the latter was confirmed by X-ray crystallog. anal. and by theor. calculations

Chemistry – A European Journal published new progress about Cycloisomerization. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Wei; Zeng, Qiang; Chen, Weiming published the artcile< Improved Synthesis of First Cell-Permeable Allosteric PTPRZ Inhibitor NAZ2329>, COA of Formula: C7H4BrF3O, the main research area is protein tyrosine phosphatase receptor allosteric inhibitor preparation antitumor activity.

NAZ2329 is the first cell-permeable small mol. allosteric inhibitor of protein tyrosine phosphatase receptor-type Z (PTPRZ), which was considered as a new potential mol. target for drug development in glioblastoma. A facile and high-efficient synthesis of NAZ2329 was developed by a straight-forward strategy starting from key ethoxy benzyl bromide intermediate obtained from com. available 4-(trifluoromethyl)phenol.

Russian Journal of General Chemistry published new progress about Antitumor agents. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, COA of Formula: C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mal, Abhijit; Wani, Imtiyaz Ahmad; Goswami, Gaurav; Ghorai, Manas K. published the artcile< Synthesis of Nonracemic 1,4-Benzoxazines via Ring Opening/Cyclization of Activated Aziridines with 2-Halophenols: Formal Synthesis of Levofloxacin>, Formula: C7H4BrF3O, the main research area is benzoxazine preparation; aziridine halophenol ring opening cyclization.

Novel 3,4-dihydro-1,4-benzoxazine derivatives have been synthesized by an efficient and simple method in excellent enantio- and diastereospecificity (ee > 99%, de > 99%). The reaction proceeds via Lewis acid-catalyzed SN2-type ring opening of activated aziridines with 2-halophenols followed by Cu(I)-catalyzed intramol. C-N cyclization in a stepwise fashion under one-pot conditions to furnish the 3,4-dihydro-1,4-benzoxazine derivatives in excellent yields (up to 95%). The strategy offers a short and efficient synthesis to (S)-3-methyl-1,4-benzoxazine (S)-3v, a late stage intermediate in the synthesis of levofloxacin.

Journal of Organic Chemistry published new progress about Aziridines Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Formula: C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mitsudo, Koichi; Kobashi, Yoshiaki; Nakata, Kaito; Kurimoto, Yuji; Sato, Eisuke; Mandai, Hiroki; Suga, Seiji published the artcile< Cu-Catalyzed Dehydrogenative C-O Cyclization for the Synthesis of Furan-Fused Thienoacenes>, HPLC of Formula: 81107-97-3, the main research area is thiophenyl phenol copper catalyst dehydrogenative cyclization coupling; furan fused thienoacene preparation.

The first Cu-catalyzed dehydrogenative C-O cyclization for the synthesis of furan-fused thienoacenes is described. A variety of heteroacenes including a thieno[3,2-b]furan or a thieno[2,3-b]furan skeleton were synthesized by intramol. C-H/O-H coupling. The use of a mixed solvent of N-methyl-2-pyrrolidone, ethylene glycol monomethyl ether, and toluene was essential for suppressing side reactions and efficiently promoting the reaction. Double C-O cyclization was also conducted to afford highly π-expanded furan-fused thienoacenes.

Organic Letters published new progress about Bond cleavage. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, HPLC of Formula: 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Uryu, Mizuho; Hiraga, Taito; Koga, Yoshito; Saito, Yutaro; Murakami, Kei; Itami, Kenichiro published the artcile< Synthesis of Polybenzoacenes: Annulative Dimerization of Phenylene Triflate by Twofold C-H Activation>, Computed Properties of 81107-97-3, the main research area is polybenzoacene preparation; phenylene triflate preparation annulative dimerization palladium catalyst; C−H activation; annulations; fused rings; palladium; polycycles.

Polycyclic aromatic hydrocarbons (PAHs) represent an emerging class of π-conjugated mols. in the area of optoelectronic devices and materials. Unprecedented synthetic routes to various PAHs from simple phenol derivatives by a palladium-catalyzed annulative dimerization of phenylene triflate through twofold inter- and intramol. C-H activation have been established. The initially formed partially fused PAHs can be smoothly transformed into a variety of fully fused PAHs by the Scholl reaction. Furthermore, the reactions of phenanthrene-substituted aryl triflates proceeded regioselectively. The findings inspired the development of a rapid and efficient synthesis of polybenzoacene derivatives This study not only allows transformation of Ph triflates, but also discloses a new retrosynthetic strategy towards PAHs, especially polybenzoacenes.

Angewandte Chemie, International Edition published new progress about C-H bond activation. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Computed Properties of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary