Category: 81107-97-3

Shanahan, Rachel M.; Hickey, Aobha; Reen, F. Jerry; O’Gara, Fergal; McGlacken, Gerard P. published the artcile< Synthesis of Benzofuroquinolines via Phosphine-Free Direct Arylation of 4-Phenoxyquinolines in Air>, Computed Properties of 81107-97-3, the main research area is benzofuroquinoline preparation; bromophenoxyquinoline palladium catalyst arylation.

A palladium-catalyzed, phosphine-free, direct arylation of 4-phenoxyquinolines for the synthesis of fused benzofuroquinolines I [R1 = H, 2-F, 2-OMe, etc.; R2 = H, 8-Me, 9-F, etc.; R3 = H, Me, n-heptyl] in air was described. Using an intramol. approach, the ring-closed products were formed in yields of up to 95 %. This approach allowed access to a range of benzofuroquinolines and an array of functional groups on both the quinoline and phenoxy rings were tolerated. Modification of the methodol. allowed the inclusion of 4-anilinoquinoline substrates, without the requirement for N-protection. Finally, electron-poor quinolines appeared to work best as evidenced by competition experiments

European Journal of Organic Chemistry published new progress about Arylation. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Computed Properties of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shimizu, Masaki; Mochida, Kenji; Katoh, Masaki; Hiyama, Tamejiro published the artcile< Synthesis and Photophysical Properties of 2-Donor-7-acceptor-9-silafluorenes: Remarkable Fluorescence Solvatochromism and Highly Efficient Fluorescence in Doped Polymer Films>, Reference of 81107-97-3, the main research area is photophys silafluorene derivative fluorescence solvatochromism.

The authors describe preparation, photophys. properties, and theor. calculations of 2-amino-7-acceptor-9-silafluorenes and show that these silafluorenes can potentially be used as novel chromophores for functional organic materials. The D-π-A type silafluorenes were prepared by Pd-catalyzed intramol. coupling of 2-(3-aminophenyldiisopropylsilyl)aryl triflates and the subsequent functional group conversion through reduction of the cyano group to a formyl and Knoevenagel condensation of the formyl group with malonitrile. The UV-visible absorption and fluorescence spectra of the D-π-A type silafluorenes exhibited a red-shift when the electron-withdrawing nature of the acceptor increased. The emission maxima of the fluorescence were highly dependent on the solvent. In the cases of formyl- and dicyanoethenyl-substituted silafluorenes, the emission colors ranged from blue to yellow for the formyl derivatives and from green to red for the dicyanoethenyl derivatives The noticeable fluorescence solvatochromism suggests the intramol. charge-transfer character of the excited states. The silafluorenes also exhibited fluorescence in the solid state (e.g., a neat thin film and a doped polymer film), and the emission color was dependent on the polarity of the polymer. In the solid state, the quantum yields of diphenylamino derivatives were generally higher than those of dimethylamino derivatives, presumably because the bulky diphenylamino group prevented chromophores from assembling close to each other. A comparison of the photophys. properties and theor. calculations of D-π-A type silafluorenes with those of the corresponding fluorenes revealed that the silicon bridge contributed to the extension of the effective conjugation length of the biphenyl moiety when the acceptor was either hydrogen, trifluoromethyl, or a cyano group, whereas there was no contribution of the silicon bridge to the π-extension in silafluorenes substituted by strong electron acceptors such as formyl and dicyanoethenyl groups. White photoluminescence was demonstrated with an excellent quantum yield of 0.81 in the solid state from the poly(Me methacrylate) film doped with Ph2N/CHO- and Ph2N/CH=(CN)2-substituted silafluorenes. This work reveals the potential of D-π-A type silafluorenes as versatile organic emitting materials.

Journal of Physical Chemistry C published new progress about Fluorescence. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Reference of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Azizollahi, Hamid; Mehta, Vaibhav P.; Garcia-Lopez, Jose-Antonio published the artcile< Pd-catalyzed cascade reactions involving skipped dienes: from double carbopalladation to remote C-C cleavage>, Category: bromides-buliding-blocks, the main research area is spirocycle preparation; diene double carbopalladation cascade palladium catalyst; allyl benzofuran preparation; skipped diene beta elimination palladium catalyst.

Herein, two ligand-controlled cascade reactions relying on the intramol. carbopalladation of skipped dienes were reported. The use of a bulky monodentate phosphine ligand afforded [4,5]-spirocycles I [R = H, 5-Me, 6-F, etc.] via sequential double carbopalladation, however bidentate phosphines promoted Pd-catalyzed remote β-C-elimination cascade to afford 3-allyl-substituted benzofurans II.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Chong; Chen, Lian-Hui; Deng, Chen-Liang; Zhang, Xing-Guo published the artcile< Synthesis of 3-trifluoromethylbenzofurans via palladium-catalyzed tandem elimination/annulation of β-chloro-β-(trifluoromethyl)styrenes with 2-halophenols>, Product Details of C7H4BrF3O, the main research area is chloro trifluoromethyl styrene halophenol palladium tandem elimination annulation catalyst; benzofuran trifluoromethyl preparation.

A palladium-catalyzed tandem elimination and annulation reaction has been developed. In this way, a variety of 3-trifluoromethylbenzofurans were prepared in moderate to good yields via tandem reaction of β-chloro-β-(trifluoromethyl)styrenes with 2-iodophenols and 2-bromophenols.

Synthesis published new progress about Aryl alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (β-chloro-β-trifluoromethyl). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Product Details of C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Klett, Johannes; Wozniak, Lukasz; Cramer, Nicolai published the artcile< 1,3,2-Diazaphospholene-Catalyzed Reductive Cyclizations of Organohalides>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is dihydrobenzofurane pyrrolidine preparation photochem; aryl alkyl halide reductive cyclization diazaphospholene hydride catalyst; Cyclizations; Diazaphospholenes; Homogeneous Catalysis; Photocatalysis; Radical Reactions.

1,3,2-Diazaphospholene hydrides (DAP-Hs) are highly nucleophilic organic hydrides serving as main-group catalysts for a range of attractive transformations. DAP hydrides can act as stoichiometric hydrogen atom transfer agents in radical reactions. Herein, authors report a DAP-catalyzed reductive radical cyclization of a broad range of aryl and alkyl halides under mild conditions. The pivotal DAP catalyst turnover was achieved by a DBU-assisted σ-bond metathesis between the formed DAP halide and HBpin, which rapidly regenerates DAP-H. The transformation is significantly accelerated by irradiation with visible light. Mechanistic investigations indicate that visible light irradiation leads to the formation of DAP dimers, which are in equilibrium with DAP radicals and accelerate the cyclization. The direct use of (DAP)2 enabled a catalytic protocol in the absence of light.

Angewandte Chemie, International Edition published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Moir, Michael; Lane, Samuel; Montgomery, Andrew P.; Hibbs, David; Connor, Mark; Kassiou, Michael published the artcile< The discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine cannabinoid type 2 receptor agonist>, Related Products of 81107-97-3, the main research area is cannabinoid type 2 receptor structure activity relationship; CB(2)R selective; Cannabinoid; Docking; Pyrazolotriazine; Structure-activity relationship study; Synthesis.

The development of selective CB2 receptor agonists is a promising therapeutic approach for the treatment of inflammatory diseases, without CB1 receptor mediated psychoactive side effects. Preliminary structure-activity relationship studies on pyrazoylidene benzamide agonists revealed the -ylidene benzamide moiety was crucial for functional activity at the CB2 receptor. A small library of compounds with varying linkage moieties between the pyrazole and substituted Ph group has culminated in the discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine agonist 19 (CB2R EC50 = 19 nM, CB1R EC50 > 10μM). Docking studies have revealed key structural features of the linkage group that are important for potent functional activity.

European Journal of Medicinal Chemistry published new progress about Cannabinoid receptor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Related Products of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Crosignani, Stefano; Pretre, Adeline; Jorand-Lebrun, Catherine; Fraboulet, Gaele; Seenisamy, Jeyaprakashnarayanan; Augustine, John Kallikat; Missotten, Marc; Humbert, Yves; Cleva, Christophe; Abla, Nada; Daff, Hamina; Schott, Olivier; Schneider, Manfred; Burgat-Charvillon, Fabienne; Rivron, Delphine; Hamernig, Ingrid; Arrighi, Jean-Francois; Gaudet, Marilene; Zimmerli, Simone C.; Juillard, Pierre; Johnson, Zoe published the artcile< Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases>, Product Details of C7H4BrF3O, the main research area is alkynylphenoxyacetic acid preparation CRTH2 receptor antagonist; DP2 receptor antagonist alkynylphenoxyacetic acid structure activity.

New phenoxyacetic acid antagonists of CRTH2 are described. Following the discovery of a hit compound, I, by a focused screening, high protein binding was identified as its main weakness. Optimization aimed at reducing serum protein binding led to the identification of several compounds that showed not only excellent affinities for the receptor (41 compounds with Ki < 10 nM) but also excellent potencies in a human whole blood assay (IC50 < 100 nM; PGD2-induced eosinophil shape change). Addnl. optimization of the pharmacokinetic characteristics led to the identification of several compounds suitable for in vivo testing. Of these, II (R1 = n-Pr, R2 = Me; R1 = n-Pr, R2 = F) were tested in two different pharmacol. models (acute FITC-mediated contact hypersensitivity and ovalbumin-induced eosinophilia models) and found to be active after oral dosing (10 and 30 mg/kg). Journal of Medicinal Chemistry published new progress about Allergic asthma. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Product Details of C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Zhipeng; He, Zhiqin; Xie, Yuxing; He, Tiantong; Fu, Yaofeng; Yu, Yang; Huang, Fei published the artcile< Bronsted acid-catalyzed homogeneous O-H and S-H insertion reactions under metal- and ligand-free conditions>, Related Products of 81107-97-3, the main research area is alkoxy acetate preparation; alc diazo compound OH bond insertion Bronsted acid catalyzed; phenylethylidene amino oxy acetate preparation; oximes with diazo compound OH insertion Bronsted acid catalyzed; thio aryl acetate preparation; thiol diazo compound SH insertion Bronsted acid catalyzed.

Under metal- and ligand-free conditions, the economical and accessible CF3SO3H successfully catalyzed homogeneous O-H bond insertion reactions between hydroxyl compounds and diazo compounds to afford alkoxy acetates. Including phenols, alcs., water and oximes, these O-H bond insertion reactions were very general and functional-group tolerant. Here, the O-H bond insertion of oximes (ketoximes and aldoximes) to gave phenylethylidene(amino(oxy)acetates) was reported and their structures were characterized by X-ray crystallog. Moreover, a simple and effective method for S-H insertion reactions of thiols to gave thio(aryl)acetates was also developed, delivering the desired C-S bond products with good to excellent yields. It was worth noting that the efficacy of the developed methodol. could be further shown by the expeditious synthesis of the PPAR agonist MBX-102 acid.

Organic Chemistry Frontiers published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Related Products of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Hengchao; Chen, Hang; Zhou, Yang; Huang, Jin; Yi, Jundan; Zhao, Hongcai; Wang, Wei; Jing, Linhai published the artcile< Selective Synthesis of Z-Cinnamyl Ethers and Cinnamyl Alcohols through Visible Light-Promoted Photocatalytic E to Z Isomerization>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is cinnamyl ether alc diastereoselective photoisomerization iridium catalyst; allylic alcohols; cinnamyl ethers; iridium; isomerization; photocatalysis.

A photocatalytic E to Z isomerization of alkenes using an iridium photosensitizer under mild reaction conditions is disclosed. This method provides scalable and efficient access to Z-cinnamyl ethers and allylic alcs. in high yields with excellent stereoselectivity. Importantly, this method also provides a powerful strategy for the selective synthesis of Z-magnolol and honokiol derivatives possessing potential biol. activity.

Chemistry – An Asian Journal published new progress about Allyl ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lux, Michaelyn C.; Boby, Melissa L.; Brooks, Joshua L.; Tan, Derek S. published the artcile< Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction>, Application In Synthesis of 81107-97-3, the main research area is diastereoselective synthesis bicyclic ether; palladium catalyzed oxidative cyclization cascade bicyclic ether synthesis.

Bicyclic ether scaffolds are found in a variety of natural products and are of interest in probe and drug discovery. A palladium-catalyzed cascade reaction has been developed to provide efficient access to these scaffolds from readily available linear diene-diol substrates [e.g., I → II, (60% isolated) with complete cis-diastereoselectivity at ring junction and 4:1 dr (α/β) at vinyl side chain]. A Pd redox-relay process is used strategically to transmit reactivity between an initial oxypalladative cyclization and a subsequent π-allyl-Pd cyclization at remote sites. The reaction affords variety of bicyclic ether scaffolds with complete diastereoselectivity for cis-ring fusion.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Application In Synthesis of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary