Category: 81107-97-3

Burns, Michael J.; Thatcher, Robert J.; Taylor, Richard J. K.; Fairlamb, Ian J. S. published the artcile< Pd-catalysed regioselective C-H functionalisation of 2-pyrones>, Product Details of C7H4BrF3O, the main research area is regioselective palladium catalyzed heterocyclization pyrone reactant benzofuropyrone preparation; pyrone reactant palladium catalyzed intramol heterocyclization benzofuropyrone preparation.

A new synthetic methodol. for the catalytic C-H functionalization of 2-pyrones is described which proceeds regioselectively at the C3 position, mirroring the observed regioselectivity in 6π-electrocyclization/oxidative aromatization reactions of related compounds to give benzofuropyrones, e.g. I. Insight into the reaction mechanism is provided, with support for a neutral palladium(II) pathway. Cationic palladium(II) complexes possessing 2-pyrones are unstable and readily undergo PdII→P transfer at ambient temperature resulting in phosphonium salt formation (and Pd0Ln species).

Dalton Transactions published new progress about C-H bond (functionalization). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Product Details of C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zaja, Mirko; Connon, Stephen J.; Dunne, Aideen M.; Rivard, Michael; Buschmann, Nicole; Jiricek, Jan; Blechert, Siegfried published the artcile< Ruthenium olefin metathesis catalysts with modified styrene ethers: influence of steric and electronic effects>, Name: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is ruthenium isopropoxybenzylidene complex preparation ring closing metathesis catalyst; functionalized styrene ether preparation reaction ruthenium complex; diene ruthenium complex catalyzed metathesis steric hindrance electronic effect; heterocyclic compound nitrogen dihydropyrrole hexahydroazocine preparation.

A series of olefin metathesis catalysts with modified isopropoxybenzylidene ligands were synthesized, and the effects of ligands on the rate of metathesis was investigated. Increased steric hindrance ortho to the isopropoxy group enhanced reaction rates. In the case of N-heterocyclic carbene complexes, decreasing electron d. at both the chelating oxygen atom and the Ru:C bond accelerated reaction rates appreciably. In an example reaction, CH2:CHCH2N(Ts)CH2CH:CH2 underwent ring-closing metathesis in the presence of (4,5-dihydroIMes)Cl2Ru:CH(2-OiPr)(4-CN)C6H3 giving N-tosyl-2,5-dihydropyrrole in 96% yield. Catalysts containing a tricyclohexylphosphine ligand, such as (PCy3)Cl2Ru:CH(2-OiPr)(5-CF3)C3H6, followed the same trend with regard to benzylidene electrophilicity, while higher electron d. at oxygen enhanced reaction rates.

Tetrahedron published new progress about Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Name: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Zeyuan; Dai, Zhen; Ma, Xinkun; Liu, Yihan; Ma, Xiaojun; Li, Wanli; Ma, Chen published the artcile< Cu-catalyzed one-pot synthesis of fused oxazepinone derivatives via sp2 C-H and O-H cross-dehydrogenative coupling>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is oxazepinone preparation; benzamide quinolinyl phenol halo cross dehydrogenative coupling copper catalyst.

An efficient Cu-catalyzed cascade reaction protocol was developed for the synthesis of fused oxazepinone derivatives I (R1 = H, 7-Cl, 8-Me, 9-CF3, etc.; R2 = H, 3-Br, 4-Cl, 3-MeO, etc.; Q = quinolin-8-yl, 5-methoxyquinolin-8-yl; A = N, C) via sp2 C-H and O-H cross-dehydrogenative coupling. A readily available catalyst, Cu2O, was used in this modular and convergent approach. An unusual Smiles rearrangement reaction was involved in this synthesis. Various reaction parameters were evaluated and optimized and the target compounds were obtained in good-to-excellent yields.

Organic Chemistry Frontiers published new progress about Benzamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaryl). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Jin; Fu, Ronghui; Jing, Linhai; Qin, Dabin; Huang, Kun; Wang, Wei published the artcile< A convenient access to 3-substituted benzofuran derivatives via palladium nanoparticles-catalyzed intramolecular Heck reaction>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is benzofuran palladium nanoparticle catalyst intramol Heck reaction.

A concise and efficiently route for the synthesis of 3-substituted benzofurans via the intramol. Heck reaction of bromoaryl 3-phenylallyl ethers has been developed. This simple and highly efficient palladium nanoparticles-catalyzed system showed good catalytic activity. The desired products were afforded in good to high yields (45%∼96%).

Youji Huaxue published new progress about Heck reaction. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yin, Biaolin; Cai, Congbi; Zeng, Guohui; Zhang, Ruoqi; Li, Xiang; Jiang, Huanfeng published the artcile< A Novel Entry to Functionalized Benzofurans and Indoles via Palladium(0)-Catalyzed Arylative Dearomatization of Furans>, Computed Properties of 81107-97-3, the main research area is benzofuran indole preparation palladium phosphine catalyst furan ring opening; furan arylation dearomatizatin palladium phosphine catalyst benzofuran indole preparation.

A novel entry to functionalized benzofurans and indoles from furans in moderate to good yields has been developed. This protocol involves palladium(0)-catalyzed dearomatizing intramol. arylation of the furan ring, formation of a π-allylic palladium complex, furan ring opening, and a β-hydride elimination sequence.

Organic Letters published new progress about Arylation (intramol.). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Computed Properties of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fier, Patrick S.; Maloney, Kevin M. published the artcile< Direct Conversion of Haloarenes to Phenols under Mild, Transition-Metal-Free Conditions>, Related Products of 81107-97-3, the main research area is phenol preparation nucleophilic aromatic substitution Lossen rearrangement haloarene; hydroxylation electron deficient haloarene heteroarene acetohydroxamic acid.

A high-yielding and practical method for the synthesis of phenols from electron-deficient haloarenes and heteroarenes has been developed. The products are formed from acetohydroxamic acid as the hydroxide source via a novel SNAr reaction/Lossen rearrangement sequence. Notably, these reactions employ inexpensive and air-stable reagents, require no special handling, occur under mildly basic conditions, and form products in high yields in the presence of electrophilic and protic functionality. The utility of this methodol. is demonstrated by the high-yielding hydroxylation of two base-sensitive complex substrates.

Organic Letters published new progress about Aromatic nitrogen heterocycles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Related Products of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yamamoto, Satoshi; Hashiguchi, Shohei; Miki, Shokyo; Igata, Yumiko; Watanabe, Toshifumi; Shiraishi, Mitsuru published the artcile< Synthesis and biological activity of novel 1,3-benzoxazine derivatives as K+ channel openers>, Synthetic Route of 81107-97-3, the main research area is benzoxazine preparation potassium channel opener.

A new series of 1,3-benzoxazine derivatives with a 2-pyridine 1-oxide group at C-4, I (R1 = Cl, Br, CF3, NO2, CCH, etc.; R2 = H, Cl, F, Br, OEt, Me), was designed to explore novel K+ channel openers. Synthesis was carried out by using a palladium(0)-catalyzed carbon-carbon bond formation reaction of imino-triflates II with organozinc reagents and via a new one-pot 1,3-benzoxazine skeleton formation reaction of benzoylpyridines. The compounds were tested for vasorelaxant activity in tetraethylammonium, chloride (TEA) and BaCl2-induced and high KCl-induced contraction of rat aorta to identify potential K+ channel openers, and also for oral hypotensive effects in spontaneously hypertensive rats. An electron-withdrawing group with the proper shape at C6 and a Me or halo group at C7 of the 1,3-benzoxazine nucleus were required for the development of optimal vasorelaxant and hypotensive activity. In particular, 2-(6-bromo-7-chloro-2,2-dimethyl-2H-1,3-benzoxazin-4-yl)pyridine 1-oxide showed more potent vasorelaxant activity (EC50 = 0.14 μm) against TEA and BaCl2-induced contraction and longer hypotensive effects than cromakalim.

Chemical & Pharmaceutical Bulletin published new progress about Potassium channel openers. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Synthetic Route of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Achard, Thierry; Belokon’, Yuri N.; Fuentes, Jose A.; North, Michael; Parsons, Teresa published the artcile< Influence of aromatic substituents on metal(II)salen catalyzed, asymmetric synthesis of α-methyl α-amino acids>, Electric Literature of 81107-97-3, the main research area is amino acid methyl asym synthesis; alanine derivative asym benzylation salen copper catalyst mol structure; transition metal Schiff base complex catalyst preparation mol structure.

The influence of substituents on both the aromatic rings of the catalyst, and the benzylidene unit of the substrate are investigated in the (salen)copper(II) catalyzed asym. benzylation of alanine derivatives Catalysts with electron-donating, and electron-withdrawing substituents of various sizes and at various locations on the aromatic rings of the salen ligand were prepared, but all exhibited inferior enantioselectivity to the parent (salen)copper(II) complex. In contrast, the introduction of halogenated substituents onto the aromatic ring of the N-benzylidene alanine Me ester substrate was found to enhance the enantioselectivity of the alkylation with a para-chloro substituent giving optimal results. A new procedure for the preparation of the catalysts which avoids the need for chromatog. on sephadex LH20 is reported, and the optimal catalyst obtained in this way was found to be a cobalt(salen) complex.

Tetrahedron published new progress about Amino acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Electric Literature of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Achard, Thierry; Belokon’, Yuri N.; Fuentes, Jose A.; North, Michael; Parsons, Teresa published the artcile< Influence of aromatic substituents on metal(II)salen catalyzed, asymmetric synthesis of α-methyl α-amino acids>, Electric Literature of 81107-97-3, the main research area is amino acid methyl asym synthesis; alanine derivative asym benzylation salen copper catalyst mol structure; transition metal Schiff base complex catalyst preparation mol structure.

The influence of substituents on both the aromatic rings of the catalyst, and the benzylidene unit of the substrate are investigated in the (salen)copper(II) catalyzed asym. benzylation of alanine derivatives Catalysts with electron-donating, and electron-withdrawing substituents of various sizes and at various locations on the aromatic rings of the salen ligand were prepared, but all exhibited inferior enantioselectivity to the parent (salen)copper(II) complex. In contrast, the introduction of halogenated substituents onto the aromatic ring of the N-benzylidene alanine Me ester substrate was found to enhance the enantioselectivity of the alkylation with a para-chloro substituent giving optimal results. A new procedure for the preparation of the catalysts which avoids the need for chromatog. on sephadex LH20 is reported, and the optimal catalyst obtained in this way was found to be a cobalt(salen) complex.

Tetrahedron published new progress about Amino acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Electric Literature of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jana, Amit Kumar; Singh, Jyotsana; Ganesher, Asha; Kumar, Amit; Banerjee, Arpita; Kumar, Deepak; Verma, Sarvesh Kumar; Sharma, Ashok Kumar; Bhatta, Rabi Sankar; Konwar, Rituraj; Panda, Gautam published the artcile< Tyrosine-Derived Novel Benzoxazine Active in a Rat Syngenic Mammary Tumor Model of Breast Cancer>, Reference of 81107-97-3, the main research area is benzoxazine derivative anticancer breast cancer apoptosis.

In continuing efforts of improving benzoxazepine derivatives as an anti-breast cancer agent, a new chem. entity, benzoxazine, was designed from scaffold morphing. Structure-activity relationship studies revealed that H, -OMe, -CF3, and -F were well tolerated on R1 and R2 positions of ring A, and R2 as -CH2CH2N(CH2)4 (N-Et pyrrolidine) and -CH2CH2N(CH2)5 (N-Et piperidine) chains on ring D increased activities (Series B, Figure 3). 13d selected as a lead compound (IC50: 0.20 to 0.65 μM) induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells. Compound 13d was formulated into 13d-f using cyclodextrin to improve its solubility for a pharmacokinetic, in vivo efficacy study. Both 13d and 13d-f regressed tumor growth at concentrations of 5 and 20 mg/kg better than tamoxifen without any mortality in a rat syngenic mammary tumor model. Collectively, our data suggest that tyrosine-derived novel benzoxazine 13d could be a potential lead for the treatment of breast cancer and hence deserve further in-depth studies.

Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Reference of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary