Category: 7766-50-9

Adding a certain compound to certain chemical reactions, such as: 7766-50-9, name is 11-Bromo-1-undecene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7766-50-9, Recommanded Product: 7766-50-9

To a solution of 11-Bromoundec-1-ene (2.2 mL, 10.1 mmol) in dry DMF (100 mL) was added 0.75 g (10.1 mmol) of NaN3. The solution was stirred for 12 h at room temperature. The reaction mixture was poured into 20 mL water and extracted with ethyl acetate (2 x 30 mL). The combined organic layer was washed with saturated NaCl solution and dried over anhydrous Na2SO4. Solvent was removed under reduced pressure to obtain the product as yellow oil. The product was used for the next step without any further purification. Yield: 1.9 g (96 %).Rf: 0.96 (1:9 Ethyl acetate & Cyclohexane).1H-NMR (CDCl3, 300 MHz, ppm): delta = 1.30 (s, 12H), 1.60 (m, 2H), 2.05 (m, 2H), 3.26 (t, J = 7.0 Hz, 2H), 4.96 (m, 2H), 5.83 (m, 1H). 13C-NMR (CDCl3, 75 MHz, ppm): delta = 26.9, 29.0, 29.1, 29.3, 29.3, 29.5, 29.6, 34.0, 51.7, 114.3, 139.3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 11-Bromo-1-undecene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Bhabak, Krishna P.; Proksch, Denny; Redmer, Susanne; Arenz, Christoph; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6154 – 6161;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7766-50-9, name is 11-Bromo-1-undecene, A new synthetic method of this compound is introduced below., Computed Properties of C11H21Br

[0129] 86 mmol of 1 1 -bromo1 -undecene and 91 mmol of triethoxy silane were added to a single neck RBF attached with an attached reflux condenser. Then 1.0 mL Karstedt’s catalyst (2 Wt. % solution in toluene, 0.1 mmol)) was added via syringe and flask was in the oil bath between 70 C for 2h. 1H NMR of the crude mixture showed a complete consumption of chain end olefin groups, however, a close examination of the spectrum showed presence of -15-20% olefin rearrangement products. Separation of (1 1 – bromoundecyl) triethoxysilane from rearrangement olefin and excess triethoxy silane was achieved by fractional distillation under high vacuum (Yield 67%).

The synthetic route of 7766-50-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; BOBADE, Sachin; POLISHCHUK, Orest; PADMANABAN, Munirathna; BASKARAN, Durairaj; (65 pag.)WO2019/81450; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 7766-50-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7766-50-9, name is 11-Bromo-1-undecene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1 ml of 50% aqueous sodium hydroxide (0.012 mol) and 23.4 g of tetra(ethylene glycol) (0.12 mol) was stirred for 0.5 h in an oil bath at 100 C. under Ar, and 2.8 g of 11-bromoundec-1-ene (0.012 mol) was then added. At the completion of the reaction as indicated by the TLC analysis, the reaction mixture was cooled and extracted several times with hexane. The combined organic layers were washed with brine and dried over sodium sulfate. After evaporation of the solvent in vacuo, the crude product was purified by chromatography column on silica gel (hexane/ethyl acetate, 1:1) to give pure product 2.5 g (yield: 60%). 1H NMR (CDCl3) delta 5.82-5.72 (m, 1H), 4.97-4.87 (m, 2H), 3.68-3.64 (t, 2H, J=4.8 Hz), 3.62-3.54 (m, 14H), 3.42-3.39 (t, 2H, J=7.2 Hz), 2.01-1.97 (m, 3H), 1.55-1.50 (m, 2H), 1.35-1.24 (m, 12H). 13C NMR (CDCl3) delta 139.5, 114.4, 72.8, 71.8, 70.8, 70.7, 70.5, 70.2, 34.0, 29.8, 29.7, 29.6, 29.3, 29.1, 26.3. MS ES+ m/z 369.28 (M+Na).

The synthetic route of 11-Bromo-1-undecene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Oakland University; Zeng, Xiangqun; Shen, Zhihong; (42 pag.)US9366672; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 7766-50-9,Some common heterocyclic compound, 7766-50-9, name is 11-Bromo-1-undecene, molecular formula is C11H21Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: p-Benzenediol (Hydroquinone, defined as BP1 here) (2.2 g,20 mmol) and sodium hydroxide (2.4 g, 60 mmol) were dissolved in 120 mL DMF in a 250-mL round bottomed Schlenk flask, then themixture was stirred for 30 min, and a solution of 11-bromo-1-undecene (12 g, 51.5 mmol) in DMF (120 mL) was added dropwise over 10 min. The resulting reaction mixture was heated at 70 C and left stirring for more than 8 h. Subsequently, the reaction was cooled to RT and quenched with addition of diethyl ether (100 mL) and water (100 mL). The aqueous phase was extracted with diethyl ether (300 mL 2), and the combined organic fractions were washed with brine and dried over MgSO4 and concentrated. The residue was recrystallized from EtOH twice to obtain 6.1 g BP1-M1. Yield: 74%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 11-Bromo-1-undecene, its application will become more common.

Reference:
Article; Song, Shaofei; Miao, Weijun; Wang, Zongbao; Gong, Dirong; Chen, Zhong-Ren; Polymer; vol. 64; (2015); p. 76 – 83;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 7766-50-9, name is 11-Bromo-1-undecene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7766-50-9, 7766-50-9

The absolute configuration of acetates 5 and 6 was confirmed by alternative chiral synthesis of (2S’,122)-2-acetoxy-12-heptadecene (6) using hydrolytic kinetic resolu- tion (HKR) as the key step (FIG. 6), as follows: 37.5 mmol of butyl lithium (15 ml of 2.5 M solution in hexane) was added under argon at -700C to 3.45 ml (30.0 mmol) of 1-hexyne (9) in 50 ml THF. After stirring 0.5 hours, 5 ml of HMPA and 1.8 ml (8.20 mmol) of 11-bromo-l-undecene (10) was added. The reaction mixture was then warmed to room temperature, stirred 24 hours, quenched with aq. NH4Cl, and extracted with hexane (2 x 50 ml). Combined extracts were washed with brine, dried (anh. MgSO4), and solvents evaporated. The crude product was filtered through 10 g of silica eluting with hexane, yielding 2.05 g of hydrocarbon 11 (85% pure by GC; 7.65 mmol). Without further purification compound 11 was treated with 13.1 mmol of r¡ã-chloroperoxybenzoic acid at 0C in 20 ml of dichloromethane. After 3 hours, the mixture was warmed to room temperature, and after a subsequent 30 min quenched with 50 ml of 2N NaOH and treated with 100 ml of ether. The organic layer was separated, washed with water and brine, and dried (anh. MgSO4). After filtration, removal of solvents in vacuo and flash chromatography, 0.82 g (87% pure by GC; 2.85 mmol) of unsaturated epoxide 12 was obtained. Epoxide 12 in 3 ml of dry THF with 0.030 ml of water was subjected to HKR with freshly prepared R,R-1 Jacobsen catalyst (7,8) [25 mg of (R,R)-N,NN -bis(3 ,5-di-tert-butylsalicylidene)-l ,2-cyclohexanediaminocobalt(II) (Aldrich Chemical Company, Milwaukee, WI) stirred 1 hour with 0.20 ml of toluene and 0.050 ml of acetic acid, and solvents removed in vacuo]. After stirring the reaction mixture 7 days, the recovered (R)-epoxide 13 was separated by flash chromatography [15 g of silica with hexanerether (80:20) as eluent] from the diol 14 and the catalyst, affording 0.4 g of 85% pure (R)-epoxide 13. After removal of solvents, 13 was dissolved in 2 ml of ether and added to a lithium aluminum hydride suspension (10 mmol) in 20 ml of ether. After stirring 3 hours, the reaction mixture was quenched with 2nu NaOH, and the organic phase removed and evaporated. The resulting acetylenic alcohol 15 was hydrogenated in 30 ml of hexane with Lindlar catalyst (5% palladium on calcium carbonate poisoned with lead, 100 mg) and 1 ml of quinoline, yielding 0.350 g of (25′,12Z)-2-hydroxy-12-heptadecene (4). Acetylation of 4, as described above, and further flash column purification gave 0.350 g (1.18 mmol) of (25,12Z)-2-acetoxy-12-heptadecene (6) (yield 14.5% based on 11-bromo-l-undecene 10) with 85% ee.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 11-Bromo-1-undecene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRIES, Regine; KHASKIN, Grigori; DAROOGHEH, Hassan; MART, Cafer; BRITTON, Robert; GRIES, Gerhard; WO2007/79563; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

The chemical industry reduces the impact on the environment during synthesis 7766-50-9, name is 11-Bromo-1-undecene, I believe this compound will play a more active role in future production and life. 7766-50-9

p-Benzenediol (Hydroquinone, defined as BP1 here) (2.2 g,20 mmol) and sodium hydroxide (2.4 g, 60 mmol) were dissolved in 120 mL DMF in a 250-mL round bottomed Schlenk flask, then themixture was stirred for 30 min, and a solution of 11-bromo-1-undecene (12 g, 51.5 mmol) in DMF (120 mL) was added dropwise over 10 min. The resulting reaction mixture was heated at 70 C and left stirring for more than 8 h. Subsequently, the reaction was cooled to RT and quenched with addition of diethyl ether (100 mL) and water (100 mL). The aqueous phase was extracted with diethyl ether (300 mL 2), and the combined organic fractions were washed with brine and dried over MgSO4 and concentrated. The residue was recrystallized from EtOH twice to obtain 6.1 g BP1-M1. Yield: 74%.

The chemical industry reduces the impact on the environment during synthesis 7766-50-9. I believe this compound will play a more active role in future production and life.

Reference:
Article; Song, Shaofei; Miao, Weijun; Wang, Zongbao; Gong, Dirong; Chen, Zhong-Ren; Polymer; vol. 64; (2015); p. 76 – 83;,
Bromide – Wikipedia,
bromide – Wiktionary