Category: 766-46-1

Related Products of 766-46-1, The chemical industry reduces the impact on the environment during synthesis 766-46-1, name is 2′-Bromophenylacetylene, I believe this compound will play a more active role in future production and life.

General procedure: To a solution of sulfonyl azides 1 (0.6 mmol), o-bromo-phenylacetylenes 2 (0.5 mmol), aromatic amines 3 (0.55 mmol), and CuI (0.05 mmol) in DMSO (2 mL) in Schlenk tube was added TEA (0.5 mmol) slowly via a syringe. The reaction solution was stirred at room temperature under N2 for 2 h. The solution was then added to CuI (0.05 mmol), K2CO3 (1 mmol), and l-proline (0.2 mmol), and the mixture was stirred at 60 C under N2 for 4 h. The reaction mixture was partitioned between ethyl acetate and saturated aq NH4Cl, the organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel with petroleum ether and ethyl acetate (6:1 to 9:1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2′-Bromophenylacetylene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jin, Hongwei; Zhou, Bingwei; Wu, Zhi; Shen, Yang; Wang, Yanguang; Tetrahedron; vol. 67; 6; (2011); p. 1178 – 1182;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 766-46-1, name is 2′-Bromophenylacetylene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 766-46-1, Application In Synthesis of 2′-Bromophenylacetylene

To a 10 mL screw cap vial, 2-bromophenylacetylene (0.5 mmol) and a solution of azidopentafluoroethane in THF (?0.60 mmol, 3-4 mL) were added. An aqueous solution of CuSO4-5H2O (1 mol·l-1, 0.05 mmol, 50 mul) and sodium L-ascorbate (1 mol·l-1, 0.05 mmol, 50 mul) were added, the vial was closed and the content was stirred at rt for 18 h. Saturated aqueous NH4Cl (10 mL) was added and the product was extracted into CH2Cl2 (3*10 mL). The combined organic phase was washed with water (2*10 mL), dried (MgSO4), filtered and solvent was removed under reduced pressure. Purification by column chromatography (silicagel) gave pure product as a white solid. Yield 37%; Rf (cyklohexane:EtOAc 95:5)=0.53; IR (CHCl3, film) v=1430, 1210, 1128, 1077, 972 cm; 1H NMR (400 MHz, CDCl3) delta=8.63 (s, 1H), 8.15 (dd, J=7.8, 1.7 Hz, 1H), 7.70 (dd, J=8.1, 1.2 Hz, 1H), 7.47 (td, J=7.6, 1.3 Hz, 1H), 7.29 (td, 1H); 13C NMR (101 MHz, CDCl3) delta=146.4, 133.9, 131.1, 130.6, 129.4, 128.1, 121.6, 121.4, 117.2 (qt, 1JC-F=287.5 Hz, 2JC-F=41.2 Hz, CF3), 110.3 (tq, 1JC-F=271.4 Hz, 1JC-F=43.2 Hz, CF2); 19F NMR (376 MHz, CDCl3) delta=-84.4 (s, 3F), -99.2 (s, 2F); HRMS (ESI) m/z calculated for C10H6N3BrF5 [M+H]+: 341.9660, found 341.9661.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2′-Bromophenylacetylene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ustav organicke chemie a biochemie AV CR, v.v.i.; CF Plus Chemicals s.r.o.; BEIER, Petr; MATOUSEK, Vaclav; BLASTIK, Zsofia E.; VOLTROVA, Svatava; (12 pag.)US2019/161452; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 766-46-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 766-46-1, name is 2′-Bromophenylacetylene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

under high purity nitrogen atmosphere, into 10ml of Schlek reaction tube was 0.02mmol benzoquinolin triphenylphosphine ring iridium hydrogen adduct material (4), 1mmol2- bromophenyl acetylene, 2mmol benzyl alcohol, and 1.0 mmol of potassium carbonate in 3ml of toluene, the reaction tube was replaced with nitrogen 3 times, then in an oil bath with magnetic stirring and heated to 110 deg.] C, the reaction was refluxed for 20 hours. Oil bath was removed, the water bath to room temperature; 3ml adding water to the reaction liquid, extracted three times with 5ml of dichloromethane, and the combined organic phases were dried over anhydrous MgSO4 for 30 minutes and filtered; the filtrate was concentrated on a rotary evaporator, the remaining oil residue ether as eluent, separated by thin layer chromatography on silica gel to give the pure product 1-phenyl-3 (2-bromophenyl) -1-propanone, yield 88%.

The synthetic route of 2′-Bromophenylacetylene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Luoyang Normal University; Li, Xiao Dong; Li, gongmei; Xu, Chen; Hao, Xin Qi; Xiao, Zhi Qiang; (10 pag.)CN103242372; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 766-46-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 766-46-1, name is 2′-Bromophenylacetylene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In a 25 mL of flask, t-BuLi (2 mmol, 1.6 M in pentane) was added dropwise at -78 C to a stirred solution of o-bromoethynylbenzene (1 mmol, 181 mg) or its derivative (1 mmol) in Et2O (5 mL) and the reaction mixture was allowed to warm to room temperature. After stirring at room temperature for 1 h, S8 (0.25 mmol, 64 mg) was added and the reaction was stirred at room temperature for 2 h. The solvent of the reaction mixture was evaporated under vacuum and THF (5 ml) was added. After that, an electrophile (2 mmol) was added dropwise at room temperature. After stirring at room temperature for 1 h, the solvent of the reaction mixture was evaporated under vacuum. The residue was purified by chromatography to give products 4 and 6.

The synthetic route of 2′-Bromophenylacetylene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Zitao; Geng, Weizhi; Wang, Hanliu; Zhang, Shaoguang; Zhang, Wen-Xiong; Xi, Zhenfeng; Tetrahedron Letters; vol. 52; 51; (2011); p. 6997 – 6999;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 766-46-1, These common heterocyclic compound, 766-46-1, name is 2′-Bromophenylacetylene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In an appropriate amount of organic solvent DMSO,Adding 100 mmol of the compound of the above formula (I),170 mmol of the compound of the above formula (II),5 mmol two-component composite catalyst (a mixture of 1.5 mmol PdCl 2 (cod) and 3.5 mmol ferrocene), 18 mmol of the above ligand L1130 mmol of oxidant m-chloroperoxybenzoic acid and 25 mmol of acid promoter trifluoroacetic acid,After joining,The temperature was raised to 45 C and the reaction was stirred at this temperature for 6 hours.After the reaction is over,Cool naturally to room temperature,filter,The filtrate was washed thoroughly with deionized water and then with acetic acidEster extraction 2-3 times,Combine the organic phase,And dried over anhydrous magnesium sulfate,Concentrated under reduced pressure,The residue was separated by silica gel column chromatography.An equal volume ratio of a mixture of n-pentane and acetone is used as an elution solvent.Thereby obtaining a compound of the above formula (III),The yield was 96.7%.

The synthetic route of 766-46-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yancheng Geruiyin Chemical Co., Ltd.; Ding Gang; (10 pag.)CN105130769; (2018); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 766-46-1, name is 2′-Bromophenylacetylene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 766-46-1, Safety of 2′-Bromophenylacetylene

General procedure: A THF solution (5.0 mL) of 1 (1.0 mmol) was treated with Bu3SnOMe (1.0 mmol) and t-BuOK (0.5 mmol). The mixture was stirred for 4.5 h under nitrogen at reflux. The reaction mixture was then treated with 3 (207.1 mg, 0.98 mmol), P(t-Bu)3 (0.035 mmol) and Pd2(dba)3 (0.018 mmol) at room temperature, and the mixture was stirred under nitrogen at room temperature for 8 h. After workup with diethylether (3 × 10.0 mL)/NH4Faq (10%, 10.0 mL), the organic layer was dried over MgSO4. After filtration, the solvents were evaporated. The crude product was subjected to column chromatography on silica gel to afford 4a-i. 4a,13 4b,10 4c,14 4d,14 4e,14 4f,14 4g,15 4h14 and 4i14 are known compounds and were identified by their previously reported spectroscopic data.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2′-Bromophenylacetylene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Peng, Li-Fen; Wang, Bing-Hao; Wang, Ming; Tang, Zi-Long; Jiang, Yan-Zi; Jiao, Yin-Chun; Xu, Xin-Hua; Journal of Chemical Research; vol. 42; 5; (2018); p. 235 – 238;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 766-46-1, name is 2′-Bromophenylacetylene, A new synthetic method of this compound is introduced below., Application In Synthesis of 2′-Bromophenylacetylene

General procedure: To the mixture of phenylacetylene (1 mmol), water (3.0 mL),silver perfluorooctanesulfonate (5 mol%) and perfluorooctane sulfonateacid (2 mol%) was added. The mixture was stirred at 100 Cfor 8 h. The solution was extracted with n-hexane (diethyl ether)(3 5 mL), the combined extract was dried with anhydrous MgSO4. The rest of the solution was used for the next cycle of reaction. Theextraction solvent was removed and the crude product was separatedby column chromatography to give the pure sample.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Dong, Qizhi; Li, Ningbo; Qiu, Renhua; Wang, Jinying; Guo, Cancheng; Xu, Xinhua; Journal of Organometallic Chemistry; vol. 799-800; (2015); p. 122 – 127;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 766-46-1, name is 2′-Bromophenylacetylene, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 766-46-1

General procedure: A solution of1-iodo-2-methoxybenzene derivatives 5a-c or 1-iodo-2-methoxynathpthlene (5d) (1.0equiv.), 1-bromo-2-ethynylbenzene (6) (1.2 equiv.), Pd(PPh3)4 (5 mol%), and CuI (5 mol%) indegassed triethylamine and degassed THF was stirred at room temperature for 15 h under a nitrogenatmosphere. The reaction mixture was diluted with CHCl3 and washed with saturated NH4Cl aq. andbrine. The organic layer was dried over MgSO4. After removal of the solvent under reduced pressure,the residue was purified by chromatography on SiO2 to give the corresponding asymmetricdiarylacetylene derivatives 3a-d. The product 3a was characterized by comparing its spectral data withprevious report.[S1] The structures of the products 3b-d were assigned by their 1H and 13C-NMR, IR,mass spectra.

According to the analysis of related databases, 766-46-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Umeda, Rui; Shimizu, Yuji; Ida, Yuta; Ikeshita, Masahiro; Suzuki, Shuichi; Naota, Takeshi; Nishiyama, Yutaka; Tetrahedron Letters; vol. 60; 2; (2019); p. 183 – 186;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 766-46-1, These common heterocyclic compound, 766-46-1, name is 2′-Bromophenylacetylene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of sulfonyl azides 1 (0.6 mmol), o-bromo-phenylacetylenes 2 (0.5 mmol), aromatic amines 3 (0.55 mmol), and CuI (0.05 mmol) in DMSO (2 mL) in Schlenk tube was added TEA (0.5 mmol) slowly via a syringe. The reaction solution was stirred at room temperature under N2 for 2 h. The solution was then added to CuI (0.05 mmol), K2CO3 (1 mmol), and l-proline (0.2 mmol), and the mixture was stirred at 60 C under N2 for 4 h. The reaction mixture was partitioned between ethyl acetate and saturated aq NH4Cl, the organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel with petroleum ether and ethyl acetate (6:1 to 9:1).

Statistics shows that 2′-Bromophenylacetylene is playing an increasingly important role. we look forward to future research findings about 766-46-1.

Reference:
Article; Jin, Hongwei; Zhou, Bingwei; Wu, Zhi; Shen, Yang; Wang, Yanguang; Tetrahedron; vol. 67; 6; (2011); p. 1178 – 1182;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 766-46-1, The chemical industry reduces the impact on the environment during synthesis 766-46-1, name is 2′-Bromophenylacetylene, I believe this compound will play a more active role in future production and life.

General procedure: A THF solution (5.0 mL) of 1 (1.0 mmol) was treated with Bu3SnOMe (1.0 mmol) and t-BuOK (0.5 mmol). The mixture was stirred for 4.5 h under nitrogen at reflux. The reaction mixture was then treated with 3 (207.1 mg, 0.98 mmol), P(t-Bu)3 (0.035 mmol) and Pd2(dba)3 (0.018 mmol) at room temperature, and the mixture was stirred under nitrogen at room temperature for 8 h. After workup with diethylether (3 × 10.0 mL)/NH4Faq (10%, 10.0 mL), the organic layer was dried over MgSO4. After filtration, the solvents were evaporated. The crude product was subjected to column chromatography on silica gel to afford 4a-i. 4a,13 4b,10 4c,14 4d,14 4e,14 4f,14 4g,15 4h14 and 4i14 are known compounds and were identified by their previously reported spectroscopic data.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2′-Bromophenylacetylene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Peng, Li-Fen; Wang, Bing-Hao; Wang, Ming; Tang, Zi-Long; Jiang, Yan-Zi; Jiao, Yin-Chun; Xu, Xin-Hua; Journal of Chemical Research; vol. 42; 5; (2018); p. 235 – 238;,
Bromide – Wikipedia,
bromide – Wiktionary