Category: 76437-44-0

Synthesis of novel fluorophenyl, furan tagged benzylthiopyrimidine derivatives was written by Maddila, Suresh;Lavanya, Palakondu;Jonnalagadda, Sreekanth B.. And the article was included in Chemija in 2013.Application of 76437-44-0 This article mentions the following:

A series of 6-(4-fluorophenyl)-2-(substituted benzylthio)-4-(furan-2-yl)-1,6- dihydropyrimidine derivatives I (R = H, 3-F, 4-CH₃, 4-NO₂, etc.) have been synthesized from 2-acetylfuran through a multi-step reaction sequence. The key intermediate II reacted with various substituted benzyl bromides in the presence of K₂CO₃ to afford the desired products, which were characterized by IR, ¹H NMR, LCMS, and elemental anal. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Application of 76437-44-0).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 76437-44-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cu²⁺ ion crosslinked carboxymethylcellulose/diatomite composite beads as an efficient catalyst for CuAAC reactions was written by Zeng, Fang;Zhang, Mingjuan;Li, Yiqun. And the article was included in Polymers for Advanced Technologies in 2021.Application of 76437-44-0 This article mentions the following:

Cu²⁺-crosslinked CM-cellulose/diatomite composite beads (CuII@CMC/DE) were prepared in simple and efficient way using ionic crosslinking techniques. In CuII@CMC/DE beads, diatomite serves as a reinforcing filler, and divalent copper cation acts as crosslinking agent. The chem. structure and morphol. of as-fabricated CuII@CMC/DE beads were well characterized using various techniques such as ICP, FT-IR, XRD, SEM, EDS, elemental mapping, TEM, XPS, and TGA. The CuII@CMC/DE beads exerted superior catalytic performance in CuAAC reactions of benzyl halides, sodium azide, and alkynes to yield regioselective 1,4-disubstituted-1,2,3-triazoles in excellent yields under green conditions. In these resultant catalytic composite beads, Cu²⁺ was used not only as a crosslinking agent but also as a metal catalyst for CuAAC reaction. The composite beads can be easily separated by filter and reused at least four times without any significant decrease on its activity and selectivity. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Application of 76437-44-0).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon闁艰京鐗梤omine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 76437-44-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, Synthesis, and Pharmacological Evaluation of Fused 灏?Homophenylalanine Derivatives as Potent DPP-4 Inhibitors was written by Jiang, Tao;Zhou, Yuren;Chen, Zhuxi;Sun, Peng;Zhu, Jianming;Zhang, Qiang;Wang, Zhen;Shao, Qiang;Jiang, Xiangrui;Li, Bo;Chen, Kaixian;Jiang, Hualiang;Wang, Heyao;Zhu, Weiliang;Shen, Jingshan. And the article was included in ACS Medicinal Chemistry Letters in 2015.Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene This article mentions the following:

Dipeptidyl peptidase-4 (DPP-4) inhibitors are accepted as a favorable class of agents for the treatment of type 2 diabetes. Herein, a series of fused 灏?homophenylalanine derivatives as novel DPP-4 inhibitors was designed, synthesized, and evaluated for their inhibitory activities against DPP-4. Most of them displayed excellent DPP-4 inhibitory activities and good selectivity. Among them, 9aa, 18a, and 18m also showed good efficacy in an oral glucose tolerance test (OGTT) in ICR mice. Moreover, when dosed 8 h prior to glucose challenge, 18m showed significantly greater potency than sitagliptin. It thus provides potential candidates for the further development into potent drugs targeting DPP-4. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of novel fluorophenyl, furan tagged benzylthiopyrimidine derivatives was written by Maddila, Suresh;Lavanya, Palakondu;Jonnalagadda, Sreekanth B.. And the article was included in Chemija in 2013.Application of 76437-44-0 This article mentions the following:

A series of 6-(4-fluorophenyl)-2-(substituted benzylthio)-4-(furan-2-yl)-1,6- dihydropyrimidine derivatives I (R = H, 3-F, 4-CH₃, 4-NO₂, etc.) have been synthesized from 2-acetylfuran through a multi-step reaction sequence. The key intermediate II reacted with various substituted benzyl bromides in the presence of K₂CO₃ to afford the desired products, which were characterized by IR, ¹H NMR, LCMS, and elemental anal. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Application of 76437-44-0).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 76437-44-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cu²⁺ ion crosslinked carboxymethylcellulose/diatomite composite beads as an efficient catalyst for CuAAC reactions was written by Zeng, Fang;Zhang, Mingjuan;Li, Yiqun. And the article was included in Polymers for Advanced Technologies in 2021.Application of 76437-44-0 This article mentions the following:

Cu²⁺-crosslinked CM-cellulose/diatomite composite beads (CuII@CMC/DE) were prepared in simple and efficient way using ionic crosslinking techniques. In CuII@CMC/DE beads, diatomite serves as a reinforcing filler, and divalent copper cation acts as crosslinking agent. The chem. structure and morphol. of as-fabricated CuII@CMC/DE beads were well characterized using various techniques such as ICP, FT-IR, XRD, SEM, EDS, elemental mapping, TEM, XPS, and TGA. The CuII@CMC/DE beads exerted superior catalytic performance in CuAAC reactions of benzyl halides, sodium azide, and alkynes to yield regioselective 1,4-disubstituted-1,2,3-triazoles in excellent yields under green conditions. In these resultant catalytic composite beads, Cu²⁺ was used not only as a crosslinking agent but also as a metal catalyst for CuAAC reaction. The composite beads can be easily separated by filter and reused at least four times without any significant decrease on its activity and selectivity. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Application of 76437-44-0).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 76437-44-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, Synthesis, and Pharmacological Evaluation of Fused β-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors was written by Jiang, Tao;Zhou, Yuren;Chen, Zhuxi;Sun, Peng;Zhu, Jianming;Zhang, Qiang;Wang, Zhen;Shao, Qiang;Jiang, Xiangrui;Li, Bo;Chen, Kaixian;Jiang, Hualiang;Wang, Heyao;Zhu, Weiliang;Shen, Jingshan. And the article was included in ACS Medicinal Chemistry Letters in 2015.Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene This article mentions the following:

Dipeptidyl peptidase-4 (DPP-4) inhibitors are accepted as a favorable class of agents for the treatment of type 2 diabetes. Herein, a series of fused β-homophenylalanine derivatives as novel DPP-4 inhibitors was designed, synthesized, and evaluated for their inhibitory activities against DPP-4. Most of them displayed excellent DPP-4 inhibitory activities and good selectivity. Among them, 9aa, 18a, and 18m also showed good efficacy in an oral glucose tolerance test (OGTT) in ICR mice. Moreover, when dosed 8 h prior to glucose challenge, 18m showed significantly greater potency than sitagliptin. It thus provides potential candidates for the further development into potent drugs targeting DPP-4. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cu²⁺ ion crosslinked carboxymethylcellulose/diatomite composite beads as an efficient catalyst for CuAAC reactions was written by Zeng, Fang;Zhang, Mingjuan;Li, Yiqun. And the article was included in Polymers for Advanced Technologies in 2021.Application of 76437-44-0 This article mentions the following:

Cu²⁺-crosslinked CM-cellulose/diatomite composite beads (CuII@CMC/DE) were prepared in simple and efficient way using ionic crosslinking techniques. In CuII@CMC/DE beads, diatomite serves as a reinforcing filler, and divalent copper cation acts as crosslinking agent. The chem. structure and morphol. of as-fabricated CuII@CMC/DE beads were well characterized using various techniques such as ICP, FT-IR, XRD, SEM, EDS, elemental mapping, TEM, XPS, and TGA. The CuII@CMC/DE beads exerted superior catalytic performance in CuAAC reactions of benzyl halides, sodium azide, and alkynes to yield regioselective 1,4-disubstituted-1,2,3-triazoles in excellent yields under green conditions. In these resultant catalytic composite beads, Cu²⁺ was used not only as a crosslinking agent but also as a metal catalyst for CuAAC reaction. The composite beads can be easily separated by filter and reused at least four times without any significant decrease on its activity and selectivity. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Application of 76437-44-0).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 76437-44-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary