Hodgson, Herbert H. et al. published their research in Journal of the Chemical Society in 1939 | CAS: 76361-99-4

3-Bromo-2-nitrophenol (cas: 76361-99-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Reference of 76361-99-4

The dissociation constants of m-halogenated phenols and of some of their mononitro derivatives was written by Hodgson, Herbert H.;Smith, Reggie. And the article was included in Journal of the Chemical Society in 1939.Reference of 76361-99-4 This article mentions the following:

Dissociation constants (Ka) at 25闁?for 0.005 N solutions of substituted phenols in 30% EtOH (by volume) or in water were calculated from pH measurements made with the glass electrode. Values of Ka 闁?107 (for 30% EtOH) were: m-fluoro-, 0.00151; 3-fluoro-6-nitro-, 2.34; 3-fluoro-2-nitro-, 1.99; 3-fluoro-4-nitro-, 1.66; m-chloro-, 0.00363; 3-chloro-2-nitro-, 1.78; 3-chloro-4-nitro-, 1.58; m-bromo-, 0.00331; 3-bromo-2-nitro-, 1.66; 3-bromo-4-nitro-, 1.45; m-iodo-, 0.00309; 3-iodo-2-nitro-, 1.29; 3-iodo-4-nitro-, 1.15. Values of Ka 闁?1010 (for water) are: m-fluoro-, 5.37; m-chloro-, 8.51; m-bromo-, 7.76; m-iodo-, 6.76. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-nitrophenol (cas: 76361-99-4Reference of 76361-99-4).

3-Bromo-2-nitrophenol (cas: 76361-99-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Reference of 76361-99-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ansari, Nurul N. et al. published their research in Tetrahedron in 2018 | CAS: 76361-99-4

3-Bromo-2-nitrophenol (cas: 76361-99-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 76361-99-4

Chemoselectivity in the Kosugi-Migita-Stille coupling of bromophenyl triflates and bromo-nitrophenyl triflates with (ethenyl)tributyltin was written by Ansari, Nurul N.;Cummings, Matthew M.;Soderberg, Bjorn C. G.. And the article was included in Tetrahedron in 2018.Reference of 76361-99-4 This article mentions the following:

Kosugi-Migita-Stille cross coupling reactions of (ethenyl)tributyltin with all isomeric permutations of bromophenyl triflate and bromo-nitrophenyl triflate were examined in order to determine the chemoselectivity of carbon-bromine vs. carbon-triflate bond coupling under different reaction conditions. In general, highly selective carbon-bromine bond cross couplings were observed for example bis(triphenylphosphine)palladium dichloride (2 mol %) in 1,4-dioxane at reflux. In contrast, reactions using the same pre-catalyst but in the presence of a three-fold excess of lithium chloride in N,N-dimethylformamide at ambient temperature were in most cases selective for coupling at the carbon-triflate bond. Overall, isolated yields and the selectivity for carbon-bromine bond coupling were significantly higher compared to carbon-triflate bond coupling. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-nitrophenol (cas: 76361-99-4Reference of 76361-99-4).

3-Bromo-2-nitrophenol (cas: 76361-99-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 76361-99-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hodgson, Herbert H. et al. published their research in Journal of the Chemical Society in 1939 | CAS: 76361-99-4

3-Bromo-2-nitrophenol (cas: 76361-99-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Reference of 76361-99-4

The dissociation constants of m-halogenated phenols and of some of their mononitro derivatives was written by Hodgson, Herbert H.;Smith, Reggie. And the article was included in Journal of the Chemical Society in 1939.Reference of 76361-99-4 This article mentions the following:

Dissociation constants (Ka) at 25鎺?for 0.005 N solutions of substituted phenols in 30% EtOH (by volume) or in water were calculated from pH measurements made with the glass electrode. Values of Ka 鑴?107 (for 30% EtOH) were: m-fluoro-, 0.00151; 3-fluoro-6-nitro-, 2.34; 3-fluoro-2-nitro-, 1.99; 3-fluoro-4-nitro-, 1.66; m-chloro-, 0.00363; 3-chloro-2-nitro-, 1.78; 3-chloro-4-nitro-, 1.58; m-bromo-, 0.00331; 3-bromo-2-nitro-, 1.66; 3-bromo-4-nitro-, 1.45; m-iodo-, 0.00309; 3-iodo-2-nitro-, 1.29; 3-iodo-4-nitro-, 1.15. Values of Ka 鑴?1010 (for water) are: m-fluoro-, 5.37; m-chloro-, 8.51; m-bromo-, 7.76; m-iodo-, 6.76. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-nitrophenol (cas: 76361-99-4Reference of 76361-99-4).

3-Bromo-2-nitrophenol (cas: 76361-99-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Reference of 76361-99-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ansari, Nurul N. et al. published their research in Tetrahedron in 2018 | CAS: 76361-99-4

3-Bromo-2-nitrophenol (cas: 76361-99-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 76361-99-4

Chemoselectivity in the Kosugi-Migita-Stille coupling of bromophenyl triflates and bromo-nitrophenyl triflates with (ethenyl)tributyltin was written by Ansari, Nurul N.;Cummings, Matthew M.;Soderberg, Bjorn C. G.. And the article was included in Tetrahedron in 2018.Reference of 76361-99-4 This article mentions the following:

Kosugi-Migita-Stille cross coupling reactions of (ethenyl)tributyltin with all isomeric permutations of bromophenyl triflate and bromo-nitrophenyl triflate were examined in order to determine the chemoselectivity of carbon-bromine vs. carbon-triflate bond coupling under different reaction conditions. In general, highly selective carbon-bromine bond cross couplings were observed for example bis(triphenylphosphine)palladium dichloride (2 mol %) in 1,4-dioxane at reflux. In contrast, reactions using the same pre-catalyst but in the presence of a three-fold excess of lithium chloride in N,N-dimethylformamide at ambient temperature were in most cases selective for coupling at the carbon-triflate bond. Overall, isolated yields and the selectivity for carbon-bromine bond coupling were significantly higher compared to carbon-triflate bond coupling. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-nitrophenol (cas: 76361-99-4Reference of 76361-99-4).

3-Bromo-2-nitrophenol (cas: 76361-99-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 76361-99-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary