Category: 76283-09-5

Wu, Shaoxiang published the artcileThe enantioselective trifluoromethylation of aromatic aldehydes by quaternary ammonium bromide and (IPr)CuF at low catalyst loading, HPLC of Formula: 76283-09-5, the publication is Journal of Fluorine Chemistry (2013), 19-29, database is CAplus.

A general catalytic enantioselective trifluoromethylation of aromatic aldehydes using (IPr)CuF and quinidine-derived quaternary ammonium salt as catalysts has been developed. A wide range of aromatic aldehydes are converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading.

Journal of Fluorine Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C13H19Br2ClN2O, HPLC of Formula: 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mei, Wenwen published the artcileSynthesis and protein-tyrosine phosphatase 1B inhibitory activity evaluation of indolepropyl based 1,3,4-oxadiazole derivatives, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Youji Huaxue (2016), 36(3), 533-539, database is CAplus.

A series of indolepropyl based 1,3,4-oxadiazole derivatives were synthesized by esterification, hydrazidation, cyclization and substitution using indolebutyric acid as starting material. The inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was evaluated. The results indicated that five compounds displayed obviously inhibitory effect against PTP1B in vitro, for instance, compound 5g exhibited the strongest PTP1B inhibitory activity with an IC₅₀ value of 6.74 μg·mL^-1. It was the first example of indolealkyl based oxadiazole derivatives showing PTP1B inhibitory activity.

Youji Huaxue published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rakowitz, D. published the artcileN-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors, Computed Properties of 76283-09-5, the publication is Pharmazie (2007), 62(8), 636-637, database is CAplus and MEDLINE.

Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, resp., were synthesized and evaluated as aldose reductase inhibitors.

Pharmazie published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Computed Properties of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rakowitz, Dietmar published the artcileSynthesis of novel phenylacetic acid derivatives with halogenated benzyl subunit and evaluation as aldose reductase inhibitors, COA of Formula: C7H5Br2F, the publication is European Journal of Pharmaceutical Sciences (2006), 27(2-3), 188-193, database is CAplus and MEDLINE.

In the course of our ongoing studies several substituted benzyloxyphenylacetic acids were prepared Comparison of their aldose reductase inhibition with the biol. activity obtained for recently evaluated benzoic acid analogs revealed the critical role of a methylene spacer between the aromatic core and the acidic function. Starting from the most potent derivative (i.e. 5d, IC₅₀ = 20.9 μM) further structural modifications were performed and their influence on the inhibitory effect was established.

European Journal of Pharmaceutical Sciences published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, COA of Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lee, Jungho published the artcileInsights into constitutional isomeric effects on donor-acceptor intermolecular arrangements in non-fullerene organic solar cells, COA of Formula: C7H5Br2F, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2019), 7(31), 18468-18479, database is CAplus.

Donor-acceptor intermol. interactions and/or arrangements are key factors determining the performance of organic solar cells (OSCs). Herein, two ITIC-based isomeric acceptors (o-F-ITIC and m-F-ITIC) with fluorine atoms at ortho and meta positions within the side chains were developed. The developed acceptors showed different interactions and/or arrangements with the donor counterpart (PBDB-T), which caused a significant variation in the power conversion efficiency (PCE) of OSCs. The PCE of the PBDB-T:o-F-ITIC device was 11.11% vs. 8.90% of the PBDB-T:m-F-ITIC device. A detailed theor. anal. of the intermol. complexes formed between F-ITICs and PBDB-T allows a determination of how the two isomeric acceptors interact differently with PBDB-T. Relative to PBDB-T:m-F-ITIC with a preferential DCI-BDD complex, PBDB-T:o-F-ITIC showed a closer donor-acceptor interaction, with a tightly packed parallel-like DCI-BDT complex, resulting in larger interfacial areas. These behavioral characteristics explain in detail the exptl. results obtained from the comparison of the two blend systems relating to elec. and morphol. properties. Moreover, transient absorption spectroscopy of PBDB-T:o-F-ITIC revealed superior hole/electron transfer and separation processes, providing further evidence of the presence of beneficial intermol. complexes. This study facilitates the understanding of the role of constitutional isomerism both in intermol. interactions and in promoting the development of high-performance OSCs.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, COA of Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Li-Jun published the artcileSynthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(10), 3473-3479, database is CAplus and MEDLINE.

Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds I (R = 4-iodobenzyl), I (R = 4-(trifluoromethyl)benzyl), I (R = 4-nitrobenzyl), I (R = (2-methylthiazol-4-yl)methyl) exhibited significantly inhibitory activities against HBV DNA replication with IC₅₀ values of 5.71, 5.36, 8.90 and 9.08 μM, resp. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C17H18N3NaO3S, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rene, Olivier published the artcileDiscovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties, Computed Properties of 76283-09-5, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(18), 4455-4461, database is CAplus and MEDLINE.

Modification of the δ-sultam ring of RORc inverse agonist 2 led to the discovery of more polar oxa-sultam 65. The less lipophilic inverse agonist (65) displayed high potency in a biochem. assay, which translated into inhibition of IL-17 production in human peripheral blood mononuclear cells. The successful reduction of lipophilicity of this new analog gave rise to addnl. improvements in ROR selectivity and aqueous kinetic solubility, as well as reduction in plasma protein binding, while maintaining high cellular permeability.

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Computed Properties of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zou, Hong Bin published the artcileDesign, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives, Synthetic Route of 76283-09-5, the publication is Bioorganic & Medicinal Chemistry (2006), 14(6), 2060-2071, database is CAplus and MEDLINE.

Five series totalling 51 of sinapyl alc. derivatives were designed and synthesized. Their cytotoxicity analyses were performed on six human tumor cell lines such as PC-3, CNE, KB, A549, BEL-7404, and HeLa. Certain sinapyl alc. derivatives showed significant cytotoxic activities. Compound I exhibited especially potent cytotoxicity against the BEL-7404 cell line with an IC₅₀ value of 0.7 μM, which showed more cytotoxic activity than the pos. control, cisplatin. The structure-cytotoxicity relationships were discussed and the CoMFA anal. was performed using the cytotoxic data against HeLa cells as a template.

Bioorganic & Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C15H21BO2, Synthetic Route of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mederski, WWKR published the artcileNovel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridines. Potent angiotensin II receptor antagonists with high affinity for both the AT₁ and AT₂ subtypes, Product Details of C7H5Br2F, the publication is European Journal of Medicinal Chemistry (1997), 32(6), 479-491, database is CAplus.

The synthesis and pharmacol. activity of balanced high affinity non-peptide angiotensin II antagonists of the AT₁ and AT₂ subtype receptors have been presented. A series of previously prepared AT₁ selective 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]-pyridines were modified at four different positions in order to increase the AT₂ binding affinity by maintaining the nanomolar activity for the AT₁ receptor. The targeted AT₂/AT₁ IC₅₀ binding ratio of ∼ 1 was achieved with a number of compounds possessing a small alkyl chain at C-2, different acetamide groups at N-5 and a 3-fluoro and 2′-carboxamidosulfonyl substituent at the biphenylmethyl moiety. These modifications led to an analog which exhibited an AT₂/AT₁ ratio of 0.74, a subnanomolar AT₁ antagonistic potency (0.18 nM) and a high metabolic stability in rat and monkey liver microsomes in vitro. After oral administration of 3 mg/kg to cynomolgus monkeys, EMD 90423 (potassium salt of the active analog) demonstrated good efficacy and a long duration of action as an antihypertensive agent.

European Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Product Details of C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Jixin published the artcileSalt-Stabilized Silylzinc Pivalates for Nickel-Catalyzed Carbosilylation of Alkenes, Product Details of C7H5Br2F, the publication is Angewandte Chemie, International Edition (2022), 61(17), e202202379, database is CAplus and MEDLINE.

The authors herein report the preparation of solid and salt-stabilized silylzinc pivalates from the corresponding silyllithium reagents via transmetalation with Zn(OPiv)₂. These resulting organosilylzinc pivalates show enhanced air and moisture stability and unique reactivity in the silylative difunctionalization of alkenes. Thus, a practical chelation-assisted Ni-catalyzed regioselective alkyl and benzylsilylation of alkenes was developed, which provides an easy method to access alkyl silanes with broad substrate scope and wide functional group compatibility. Kinetic experiments highlight that the OPiv-coordination is crucial to improve the reactivity of silylzinc pivalates. Also, late-stage functionalizations of druglike mols. and versatile modifications of the products illustrate the synthetical utility of this protocol.

Angewandte Chemie, International Edition published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C12H16N2O2, Product Details of C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary