Category: 76283-09-5

《Development of 18F-labeled radiotracers for PET imaging of the adenosine A2A receptor: synthesis, radiolabeling and preliminary biological evaluation》 was published in International Journal of Molecular Sciences in 2021. These research results belong to Lai, Thu Hang; Schroder, Susann; Toussaint, Magali; Dukic-Stefanovic, Sladjana; Kranz, Mathias; Ludwig, Friedrich-Alexander; Fischer, Steffen; Steinbach, Jorg; Deuther-Conrad, Winnie; Brust, Peter; Moldovan, Rares-Petru. Product Details of 76283-09-5 The article mentions the following:

The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomog. (PET) radiotracer to monitor changes of receptor d. and/or occupancy during the A2AR-tailored therapy, authors designed a library of fluorinated analogs based on a recently published lead compound (PPY). Among those, the highly affine 4-fluorobenzyl derivate (Ki(hA2AR) = 5.3 nM) and the 2-fluorobenzyl derivate (Ki(hA2AR) = 2.1 nM) were chosen for 18F-labeling via an alc. enhanced copper-mediated procedure starting from the corresponding boronic acid pinacol ester precursors. Investigations of the metabolic stability of compound I (R = p-18F, o-18F) in CD-1 mice by radio-HPLC anal. revealed parent fractions of more than 76% of total activity in the brain. Specific binding of I (R = o-18F)on mice brain slices was demonstrated by in vitro autoradiog. In vivo PET/magnetic resonance imaging (MRI) studies in CD-1 mice revealed a reasonable high initial brain uptake for both radiotracers, followed by a fast clearance. After reading the article, we found that the author used 4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Product Details of 76283-09-5)

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Product Details of 76283-09-5Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 76283-09-5On March 15, 2019, Ndikuryayo, Ferdinand; Kang, Wei-Ming; Wu, Feng-Xu; Yang, Wen-Chao; Yang, Guang-Fu published an article in European Journal of Medicinal Chemistry. The article was 《Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors》. The article mentions the following:

Involved in the tyrosine degradation pathway, 4-hydroxyphenylpyruvate dioxygenase (HPPD) is an important target for treating type I tyrosinemia. To discover novel HPPD inhibitors, we proposed a hydrophobicity-oriented drug design (HODD) strategy based on the interactions between HPPD and the com. drug NTBC. Most of the new compounds showed improved activity, compound d23 being the most active candidate (IC50 = 0.047 μM) with about 2-fold more potent than NTBC (IC50 = 0.085 μM). Therefore, compound d23 is a potential drug candidate to treat type I tyrosinemia. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Product Details of 76283-09-5)

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Product Details of 76283-09-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Insights into constitutional isomeric effects on donor-acceptor intermolecular arrangements in non-fullerene organic solar cells》 was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019. These research results belong to Lee, Jungho; Go, Eun Min; Dharmapurikar, Satej; Xu, Jianqiu; Lee, Sang Myeon; Jeong, Mingyu; Lee, Kyu Cheol; Oh, Jiyeon; Cho, Yongjoon; Zhang, Chunfeng; Xiao, Min; Kwak, Sang Kyu; Yang, Changduk. Formula: C7H5Br2F The article mentions the following:

Donor-acceptor intermol. interactions and/or arrangements are key factors determining the performance of organic solar cells (OSCs). Herein, two ITIC-based isomeric acceptors (o-F-ITIC and m-F-ITIC) with fluorine atoms at ortho and meta positions within the side chains were developed. The developed acceptors showed different interactions and/or arrangements with the donor counterpart (PBDB-T), which caused a significant variation in the power conversion efficiency (PCE) of OSCs. The PCE of the PBDB-T:o-F-ITIC device was 11.11% vs. 8.90% of the PBDB-T:m-F-ITIC device. A detailed theor. anal. of the intermol. complexes formed between F-ITICs and PBDB-T allows a determination of how the two isomeric acceptors interact differently with PBDB-T. Relative to PBDB-T:m-F-ITIC with a preferential DCI-BDD complex, PBDB-T:o-F-ITIC showed a closer donor-acceptor interaction, with a tightly packed parallel-like DCI-BDT complex, resulting in larger interfacial areas. These behavioral characteristics explain in detail the exptl. results obtained from the comparison of the two blend systems relating to elec. and morphol. properties. Moreover, transient absorption spectroscopy of PBDB-T:o-F-ITIC revealed superior hole/electron transfer and separation processes, providing further evidence of the presence of beneficial intermol. complexes. This study facilitates the understanding of the role of constitutional isomerism both in intermol. interactions and in promoting the development of high-performance OSCs. The experimental process involved the reaction of 4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Formula: C7H5Br2F)

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Formula: C7H5Br2F Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary