Category: 76006-33-2

In 2010,Bourne, Gregory T.; Kuster, Daniel J.; Marshall, Garland R. published 《Synthesis of the Phenylpyridal Scaffold as a Helical Peptide Mimetic》.Chemistry – A European Journal published the findings.Application In Synthesis of 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

Phenylpyridal- and phenyldipyridal-based scaffolds have been designed and synthesized as novel helical peptide mimetics. The synthesis required optimization and selective alkylation in producing 2,6-functionalized 3-hydroxypyridine derivatives for a convergent scheme. The pyridine analogs were coupled by a series of Suzuki/Stille types cross-coupling reactions. A series of biaryl and teraryl substituted heterocycles, e.g. I, were produced. The synthetic approach was concise and high yielding allowing large variability at the wanted side-chain attachment points. A number of compounds were synthesized to show the versatility of the strategy.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Application In Synthesis of 3-Bromo-2-methylbenzoic acid) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. Application In Synthesis of 3-Bromo-2-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of 3-Bromo-2-methylbenzoic acidIn 2018 ,《Regioselective Functionalization of 4-Methyl-1H-indole for Scalable Synthesis of 2-Cyano-5-formyl-4-methyl-1H-indole》 appeared in Organic Process Research & Development. The author of the article were Zhang, Jun; Hu, Yun; Wang, Haiyu; Guo, Aixin; Kong, Jianshe; Ma, Rujian; Wu, Tao; Wang, Yi; Li, Lian-Sheng; Mai, Wanping; Ren, Pingda; Deng, Xiaohu. The article conveys some information:

We report a five-step synthesis of 2-cyano-5-formyl-4-methyl-1H-indole through sequential functionalization of readily available 4-methyl-1H-indole. Cyano and aldehyde functionalities are regioselectively installed at the 2 and 5 position, resp. The sequence is concise and high-yielding, amenable for kilogram scale production In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Quality Control of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of 3-Bromo-2-methylbenzoic acid Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Reaction Chemistry & Engineering included an article by Aand, Dnyaneshwar; Mahajan, Bhushan; Pabbaraja, Srihari; Singh, Ajay K.. Electric Literature of C8H7BrO2. The article was titled 《Integrated continuous flow/batch protocol for the photoreduction of ortho-methyl phenyl ketones using water as the hydrogen source》. The information in the text is summarized as follows:

Direct utilization of the abundant hydrogen in water for the transfer hydrogenation reaction (THR) is a very attractive and challenging research area. Herein, the first integrated photo-transfer hydrogenation reaction (PTHR) platform for the synthesis of benzhydrol derivatives R1CH(OH)R2 (R1 = Ph, 2-MeC6H4, 4-FC6H4, etc.; R2 = Ph, 2,5-(Me)2C6H3, 3,4-(Me)2C6H3) (26 examples, 33-89% yields) with water as a green reducing agent is reported. This transformation is time and labor-efficient, catalyst-free, and economical and utilizes readily available hydrocarbon(s) (o-Me Ph ketones) as starting materials.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Electric Literature of C8H7BrO2) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Electric Literature of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 76006-33-2In 2020 ,《Determination and Analysis of Solubility of 3-Bromo-2-Methylbenzoic Acid in Different Solvent Systems at Different Temperatures (T = 278.15-328.15 K)》 was published in Journal of Chemical & Engineering Data. The article was written by Gu, Yuanyun; Yang, Wenge; Hao, Aixiang; Xu, Qiang; Hu, Yonghong. The article contains the following contents:

In the present study, the solubility properties of 3-bromo-2-Me benzoic acid were studied by the gravimetric method under atm. pressure. In this experiment, we chose the following eight pure solvents and three binary solvent mixtures: THF, N,N-dimethylformamide, methanol, Et acetate, ethanol, acetonitrile, water, cyclohexane, (water + N,N-dimethylformamide), (Et acetate + Tetrahydrofuran), and (acetonitrile + N,N-dimethylformamide), resp. The exptl. temperature ranged from 278.15 to 328.15 K. The solubility data of 3-bromo-2-Me benzoic acid in different pure solvents were fitted by the modified Apelblat model and the Buchowski-Ksiazaczak λh model. For the solubility data of 3-bromo-2-Me benzoic acid in the three groups of binary solvent mixtures, two binary solvents – solvent-fitting models (combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) model and Jouyban-Acree model) and the modified Apelblat model- were used. By comparing the fitting results of each model, it could be seen that as long as the initial component was determined, the modified Apelblat model had a better correlation in both pure solvents and binary solvent mixtures The exptl. data showed that water, acetonitrile, or cyclohexane could be used as effective antisolvents of 3-bromo-2-Me benzoic acid. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.HPLC of Formula: 76006-33-2 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of 3-Bromo-2-methylbenzoic acidIn 2009 ,《O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Xu, Baihua; Lv, Binhua; Feng, Yan; Xu, Ge; Du, Jiyan; Welihinda, Ajith; Sheng, Zelin; Seed, Brian; Chen, Yuanwei. The article contains the following contents:

Two series of O-spiro C-aryl glucosides were synthesized and tested for inhibition of hSGLT1 and hSGLT2. 6′-O-Spiro C-aryl glucosides exhibited potent in vitro hSGLT2 inhibitory activity but 2′-O-spiro C-aryl glucosides showed no in vitro hSGLT2 inhibitory activity at a screening concentration of 1 μM. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Quality Control of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Quality Control of 3-Bromo-2-methylbenzoic acid The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2013,Vankadari, Srinivas Rao; Mandala, Devender; Pochampalli, Jalapathi; Tigulla, Parthasarathy; Valeru, Anil; Thampu, Rajakomuraiah published 《Synthesis, evaluation of antimicrobial activity, and molecular modeling of novel 2-((4-(2H-benzo[d] [1,2,3] triazol-2-yl)piperidin-1-yl)methyl)-5-substituted phenyl-1,3,4-oxadiazoles》.Medicinal Chemistry Research published the findings.COA of Formula: C8H7BrO2 The information in the text is summarized as follows:

A new series of 2-((4-(2H-benzo[d][1,2,3]triazol-2-yl)piperidin-1-yl)methyl)-5-substituted-phenyl-1,3,4-oxadiazoles I [Ar = Ph, 2-Br-Ph, 3-MeOPh, 3-NO2Ph, etc.] were synthesized by cyclization of 4-((benzotriazol-2-yl)-piperidin-1-yl)-acetic acid hydrazide with various substituted aromatic carboxylic acids in the presence of POCl3. The structures were characterized by spectral data. The representative examples were screened in vitro antibacterial activity and antifungal activity. The compounds showed significant antibacterial activity and showed moderate antifungal activity as that of standards, resp. The data were further compared with structure-based investigations using docking studies with the crystal structure of oxidoreductase (1XDQ) protein organism: Escherichia coli for antibacterial activity and oxidoreductase (3QLS) protein, organism: Candida albicans for antifungal activity. The score values estimated by genetic algorithm were found to have a good correlation with the exptl. inhibitory potencies. The experimental part of the paper was very detailed, including the reaction process of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2COA of Formula: C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. COA of Formula: C8H7BrO2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2009,Gao, Shuanhu; Wang, Qiaoling; Chen, Chuo published 《Synthesis and Structure Revision of Nakiterpiosin》.Journal of the American Chemical Society published the findings.Related Products of 76006-33-2 The information in the text is summarized as follows:

This manuscript describes a convergent synthesis and the revision of the relative stereochem. of nakiterpiosin (I), a marine C-nor-D-homosteroid. Our synthesis features a late-stage carbonylative Stille cross-coupling reaction and a photo-Nazarov cyclization reaction that deliver the complete nakiterpiosin skeleton efficiently. In the part of experimental materials, we found many familiar compounds, such as 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2013,Xia, Guangxin; You, Xiaodi; Liu, Lin; Liu, Haiyan; Wang, Jianfa; Shi, Yufang; Li, Ping; Xiong, Bing; Liu, Xuejun; Shen, Jingkang published 《Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors》.European Journal of Medicinal Chemistry published the findings.Related Products of 76006-33-2 The information in the text is summarized as follows:

The potential roles of 11β-HSD1 inhibitors in metabolic syndrome, T2D and obesity were well established and currently several classes of 11β-HSD1 inhibitors have been developed as promising agents against metabolic diseases. To find potent compounds with good pharmacokinetics, the authors used the bioisosterism approach, and designed the compounds I (R = Ph, cyclohexyl) bearing a 1,2,4-oxadiazole ring to replace the amide group in compound II. Guided by docking study, they then transformed compound I (R = phenyl) into a potent lead compound III by changing the sulfonamide group to an amide. To elaborate this series of piperidyl-oxadiazole derivatives as human 11β-HSD1 inhibitors, they explored the structure-activity relationship of several parts of the lead compound Based on their potency toward human 11β-HSD1 two compounds IV (R1 = 2-Me-3-Br-C6H3, cyclohexyl) were advanced to pharmacokinetic study. It was found that compounds IV are potent and selective human 11β-HSD1 inhibitors with better pharmacokinetic properties than those of the original piperidine-3-carboxamide compound II, and suitable for further in vivo preclin. study in primate model. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2015,Zhang, Xi-Sha; Zhang, Yun-Fei; Li, Zhao-Wei; Luo, Fei-Xian; Shi, Zhang-Jie published 《Synthesis of Dibenzo[c,e]oxepin-5(7H)-ones from Benzyl Thioethers and Carboxylic Acids: Rhodium-Catalyzed Double C-H Activation Controlled by Different Directing Groups》.Angewandte Chemie, International Edition published the findings.COA of Formula: C8H7BrO2 The information in the text is summarized as follows:

A rhodium(III)-catalyzed cross-coupling of benzyl thioethers and aryl carboxylic acids through the two directing groups is reported. Useful structures with diverse substituents were efficiently synthesized in one step with the cleavage of four bonds, such as carbon-hydrogen bond (C-H bond), carbon-sulfur bond (C-S bond), oxygen-hydrogen bond (O-H bond) and the formation of two bonds (carbon-carbon bond C-C bond) and carbon-oxygen bond (C-O bond) formation. The formed structure is the privileged core in natural products and bioactive mols. This work highlights the power of using two different directing groups to enhance the selectivity of a double C-H activation, the first of such examples in cross-oxidative coupling. Under optimized conditions the synthesis of the target compounds was achieved using di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]dirhodium or tris(acetonitrile)[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]rhodium(2+) bis[hexafluoroantimonate] as catalysts. Starting materials included benzyl thioethers, such as [(Methylthio)methyl]benzene derivatives and benzoic acid derivatives The title compounds thus formed included Dibenz[c,e]oxepin-5(7H)-one derivatives, 3,9-dimethyldibenz[c,e]oxepin-5(7H)-one. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2COA of Formula: C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. COA of Formula: C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2010,Payne, Sara L.; Rodriguez-Aristegui, Sonsoles; Bardos, Julia; Cano, Celine; Golding, Bernard T.; Hardcastle, Ian R.; Peacock, Marcus; Parveen, Nahida; Griffin, Roger J. published 《Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

Replacement of the core heterocycle of a defined series of chromen-4-one DNA-PK inhibitors by the isomeric chromen-2-one (coumarin) and isochromen-1-one (isocoumarin) scaffolds was investigated. Structure-activity relationships for DNA-PK inhibition were broadly consistent, albeit with a reduction of potency compared with the parent chromenone. In the experiment, the researchers used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Recommanded Product: 3-Bromo-2-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary