Category: 76006-33-2

Wang, Huai-Wei; Wu, Jia-Xue; Huang, Xian-Qiang; Li, Da-Cheng; Wang, Su-Na; Lu, Yi; Dou, Jian-Min published an article in 2022. The article was titled 《RhIII-Catalyzed C-H N-Heteroarylation and Esterification Cascade of Carboxylic Acid with Organoboron Reagents and 1,2-Dichloroethane in One-Pot Synthesis》, and you may find the article in Organic Letters.HPLC of Formula: 76006-33-2 The information in the text is summarized as follows:

A RhIII-catalyzed C(sp2)-H N-heteroarylation and esterification cascade of aryl carboxylic acids with N-heteroaromatic boronates and 1,2-dichloroethane in a one-pot synthesis has been disclosed. The strong coordinating ability of ortho- and meta-substituted pyridine boronates and pyrazoles as well as unsubstituted pyrimidine allows them to serve as the coupling partners. This protocol allows late-stage modification of the key precursor of roflumilast and compounds of pharmaceutical interest, which highlights the potential application of this synthetic method. The experimental part of the paper was very detailed, including the reaction process of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.HPLC of Formula: 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2011,Trabanco, Andres A.; Duvey, Guillaume; Cid, Jose Maria; Macdonald, Gregor J.; Cluzeau, Philippe; Nhem, Vanthea; Furnari, Rocco; Behaj, Nadia; Poulain, Geraldine; Finn, Terry; Poli, Sonia; Lavreysen, Hilde; Raux, Alexandre; Thollon, Yves; Poirier, Nicolas; D’Addona, David; Andres, Jose Ignacio; Lutjens, Robert; Le Poul, Emmanuel; Imogai, Hassan; Rocher, Jean-Philippe published 《New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones》.MedChemComm published the findings.Electric Literature of C8H7BrO2 The information in the text is summarized as follows:

A series of N-propyl-5-substituted isoquinolones was identified as pos. allosteric modulators (PAM) of metabotropic glutamate receptor 2 (mGluR2) via high-throughput screening (HTS). The subsequent synthesis and preliminary SAR exploration that led to the identification of compound 20 are described. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Electric Literature of C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Electric Literature of C8H7BrO2 Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Aihara, Yoshinori; Chatani, Naoto published 《Nickel-Catalyzed Reaction of C-H Bonds in Amides with I2: ortho-Iodination via the Cleavage of C(sp2)-H Bonds and Oxidative Cyclization to β-Lactams via the Cleavage of C(sp3)-H Bonds》.ACS Catalysis published the findings.Computed Properties of C8H7BrO2 The information in the text is summarized as follows:

The first example of the nickel(II)-catalyzed reaction of amides using inexpensive and milder mol. iodine (I2) as an iodinating reagent is reported. The reaction of aromatic amides having an 8-amino-5-chloroquinoline as a directing group with I2 resulted in the production of ortho-iodination products. Deuterium labeling experiments indicate that the cleavage of C-H bonds is irreversible and is likely the rate-determining step, which is in sharp contrast to the previously reported transformation using the same Ni(II) catalyst/8-aminoquinoline chelation system. The reaction is applicable to the synthesis of β-lactams from aliphatic amides as the substrate, in which C(sp3)-H bonds are activated. The results of deuterium labeling experiments indicate that the cleavage of C(sp3)-H bonds is also irreversible.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Computed Properties of C8H7BrO2) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Computed Properties of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Hu, Xiao-Qiang; Hu, Zhiyong; Trita, A. Stefania; Zhang, Guodong; Goossen, Lukas J. published 《Carboxylate-directed C-H allylation with allyl alcohols or ethers》.Chemical Science published the findings.Quality Control of 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

A [Ru(p-cymene)Cl2]2 catalyst activated allyl alcs. and ethers for the regioselective ortho-C-H allylation of aromatic and heteroaromatic carboxylates. The reaction was orthogonal to most C-H functionalizations with allyl alcs. in that allyl arenes rather than carbonyl compounds were obtained. A wide range of substrates were thus smoothly transformed to allylarenes at 50 ° in phosphate-buffered 2,2,2-trichloroethanol. The reaction concept combined the use of abundant reagents and directing groups in a sustainable, waste-minimized method for C-C bond formation. The results came from multiple reactions, including the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Quality Control of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of 3-Bromo-2-methylbenzoic acid Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Zherikova, Kseniya V.; Svetlov, Aleksey A.; Kuratieva, Natalia V.; Verevkin, Sergey P. published 《Structure-property relationships in halogenbenzoic acids: Thermodynamics of sublimation, fusion, vaporization and solubility》.Chemosphere published the findings.Reference of 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

Temperature dependences of vapor pressures for 2-, 3-, and 4-bromobenzoic acid, as well as for five isomeric bromo-methylbenzoic acids were studied by the transpiration method. Melting temperatures and enthalpies of fusion for all isomeric bromo-methylbenzoic acids and 4-bromobenzoic acid were measured with a DSC. The molar enthalpies of sublimation and vaporization were derived. These data together with results available in the literature were collected and checked for internal consistency using a group-additivity procedure and results from X-ray structural diffraction studies. Specific (hydrogen bonding) interactions in the liquid and in the crystal phase of halogenbenzoic acids were quantified based on exptl. values of vaporization and sublimation enthalpies. Structure-property correlations of solubilities of halogenobenzoic acids with sublimation pressures and sublimation enthalpies were developed and solubilities of bromo-benzoic acids were estimated These new results resolve much of the ambiguity in the available thermochem. and solubility data on bromobenzoic acids. The approach based on structure property correlations can be applied for the assessment of water solubility of sparingly soluble drugs. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Reference of 3-Bromo-2-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs》 was written by Carter, David S.; Jacobs, Robert T.; Freund, Yvonne R.; Berry, Pamela W.; Akama, Tsutomu; Easom, Eric E.; Lunde, Christopher S.; Rock, Fernando; Stefanakis, Rianna; McKerrow, James; Fischer, Chelsea; Bulman, Christina A.; Lim, Kee Chong; Suzuki, Brian M.; Tricoche, Nancy; Sakanari, Judy A.; Lustigman, Sara; Plattner, Jacob J.. Synthetic Route of C8H7BrO2 And the article was included in ACS Infectious Diseases in 2020. The article conveys some information:

The optimization of a series of benzimidazole-benzoxaborole hybrid mols. linked via a ketone that exhibit good activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness, is described. The lead identified in this series, 21 (AN15470), was found to have acceptable pharmacokinetic properties to enable an evaluation following oral dosing in an animal model of onchocerciasis. Compound 21was effective in killing worms implanted in Mongolian gerbils when dosed orally as a suspension at 100 mg/kg/day for 14 days but not when dosed orally at 100 mg/kg/day for 7 days. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Synthetic Route of C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Synthetic Route of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Sien; He, Bangyue; Li, Hongyi; Zhang, Xiaofeng; Shang, Yaping; Su, Weiping published their research in Chemistry – A European Journal in 2021. The article was titled 《Facile Synthesis of Alkylidene Phthalides by Rhodium-Catalyzed Domino C-H Acylation/Annulation of Benzamides with Aliphatic Carboxylic Acids》.Related Products of 76006-33-2 The article contains the following contents:

Facile synthesis of alkylidene phthalides I [R1 = H, Me, Ph, etc.; R2 = H, 3-Me, 3-Ph, etc.; R3 = H, Me, Et, etc.; R4 = Et, i-Pr, n-Bu, etc; R3R4 = CH2(CH2)2CH2, CH2(CH2)4CH2] by rhodium-catalyzed domino C-H acylation/annulation of benzamides with aliphatic carboxylic acids. The Rh-catalyzed ortho-C(sp2)-H functionalization of 8-aminoquinoline-derived benzamides with aliphatic acyl fluorides generated in situ from the corresponding acids was developed. This reaction initiated with 8-aminoquinoline-directed ortho-C(sp2)-H acylation, which was accompanied by subsequent intramol. nucleophilic acyl substitution of amide group to produce alkylidene phthalides. This approach exhibited high stereo-selectivity for Z-isomer products and tolerates a variety of functional groups as well as aliphatic carboxylic acids with diverse structural scaffolds. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 76006-33-2In 2020 ,《Nickel-catalyzed dual C(sp2)-H activation of arenes: a new route to diaryl ethers》 appeared in Organic Chemistry Frontiers. The author of the article were Lv, Ningning; Chen, Zhengkai; Yu, Shuling; Liu, Zhanxiang; Zhang, Yuhong. The article conveys some information:

Diaryl ethers were synthesized directly from simple arenes for the first time through dual C(sp2)-H activation with the aid of a bidentate auxiliary by nickel catalysis. The anion of the additive is crucial to the transformation, and the control experiments revealed that the acyloxylated benzamide was the key intermediate. The results came from multiple reactions, including the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Tianyu; Cai, Shi; Cheng, Yao; Zhang, Wanheng; Wang, Minmin; Sun, Huiyong; Guo, Binghua; Li, Zheng; Xiao, Yibei; Jiang, Sheng published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation》.Recommanded Product: 76006-33-2 The author mentioned the following in the article:

Several monoclonal antibodies targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) pathway have been used successfully in anticancer immunotherapy. Inherent limitations of antibody-based therapies remain, however, and alternative small-mol. inhibitors that can block the PD-1/PD-L1 axis are urgent needed. Herein, we report the discovery of compound 17 as a bifunctional inhibitor of PD-1/PD-L1 interactions. 17 inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1. 17 promotes cell-surface PD-L1 internalized into the cytosol and induces the degradation of PD-L1 in tumor cells through a lysosome-dependent pathway. Furthermore, 17 suppresses tumor growth in vivo by activating antitumor immunity. These results demonstrate that 17 targets the PD-1/PD-L1 axis and induces PD-L1 degradation The results came from multiple reactions, including the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: 76006-33-2 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2015,Zhao, Xinge; Xin, Minhang; Huang, Wei; Ren, Yanliang; Jin, Qiu; Tang, Feng; Jiang, Hailong; Wang, Yazhou; Yang, Jie; Mo, Shifu; Xiang, Hua published 《Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton’s tyrosine kinase inhibitors》.Bioorganic & Medicinal Chemistry published the findings.Reference of 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

A series of novel reversible Btk inhibitors has been designed based on the structure of the recently reported preclin. drug RN486. The synthesis and SAR of these compounds are described. Among these derivatives, compound (I) was identified to be a potent and orally available reversible agent with satisfactory Btk enzymic and cellular inhibition in vitro, as well as favorable PK properties and inhibition of arthritis in vivo. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Reference of 3-Bromo-2-methylbenzoic acid The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary