Category: 76006-33-2

In 2018,Tetrahedron included an article by Rashad, Adel A.; Neyts, Johan; Leyssen, Pieter; Keller, Paul A.. Category: bromides-buliding-blocks. The article was titled 《A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of Chikungunya virus replication》. The information in the text is summarized as follows:

Mycophenolic acid (MPA) has been previously reported as an inhibitor of the Chikugunya virus (CHIKV) with an EC50 value of 0.2 μM. We used MPA as a lead compound designing and synthesizing a series of isatins and benzolactones in a typical medicinal chem. program. The synthesis and testing of 19 derivatives produced compounds with no desired activity which prompted us to retest the lead compound, MPA. We can reveal that MPA shows no anti-CHIKV activity and therefore needs to be reassessed as a lead compound for this target. In addition to this study using 3-Bromo-2-methylbenzoic acid, there are many other studies that have used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Category: bromides-buliding-blocks) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Category: bromides-buliding-blocks Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Rh-Catalyzed Annulation of Benzoic Acids, Formaldehyde, and Malonates via ortho-Hydroarylation to Indanones》 was published in Organic Letters in 2020. These research results belong to Yu, Shuling; Lv, Ningning; Hong, Chao; Liu, Zhanxiang; Zhang, Yuhong. Product Details of 76006-33-2 The article mentions the following:

A three-component reaction from readily available low-cost materials of benzoic acids, formaldehyde, and malonates for the preparation of indanones by rhodium catalysis is reported. The annulation is initiated by an ortho-hydroarylation of benzoic acids, and a Lewis acid is not required. The solvent has a significant influence to the reaction, and 2-substituted or nonsubstituted indanones are obtained by the change of solvent. In addition to this study using 3-Bromo-2-methylbenzoic acid, there are many other studies that have used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Product Details of 76006-33-2) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Product Details of 76006-33-2 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ACS Catalysis included an article by Zhang, Guodong; Hu, Zhiyong; Bertoli, Giulia; Goossen, Lukas J.. Application In Synthesis of 3-Bromo-2-methylbenzoic acid. The article was titled 《Iridium-Catalyzed Synthesis of Substituted Indanones from Aromatic Carboxylates and Unsaturated Ketones》. The information in the text is summarized as follows:

A catalytic annulation is presented that provides straightforward, modular synthetic access to 3-substituted indanones from benzoic acids and α,β-unsaturated ketones. It is catalyzed by a bimetallic Ir/In system and proceeds via hydroarylation followed by Claisen condensation and optional retro-Claisen deacylation. The annulation may be combined into a one-pot procedure with the synthesis of the unsaturated ketone substrates from aldehydes and acetone. Two complementary reaction protocols are provided that are applicable to diversely functionalized electron-rich and electron-poor substrates. In the experiment, the researchers used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Application In Synthesis of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Application In Synthesis of 3-Bromo-2-methylbenzoic acid In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Selectively Oxidative C(sp2)-H/C(sp3)-H Cross-Coupling of Benzamides with Amides by Nickel Catalysis》 was published in Organic Letters in 2020. These research results belong to Lv, Ningning; Yu, Shuling; Hong, Chao; Han, De-Man; Zhang, Yuhong. Quality Control of 3-Bromo-2-methylbenzoic acid The article mentions the following:

The oxidative cross-coupling between the α-C(sp3)-H bond of amide in DMAc and the inert ortho-C(sp2)-H bond of benzamides is achieved for the first time by nickel catalysis, with the assistance of 8-aminoquinolyl group in the presence of a silver oxidant. Notably, the selectivity of conversion can be perfectly controlled by modulating the oxidant additives, and the products from the coupling of the C(sp3)-H bond adjacent to nitrogen of amides with benzamides are approached through the use of peroxide. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Quality Control of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Quality Control of 3-Bromo-2-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Siyuan; Zhou, Yangkun; Huang, Hanmin published their research in Organic Letters in 2021. The article was titled 《Palladium-Catalyzed Tandem Carbonylative Diels-Alder Reaction for Construction of Bridged Polycyclic Skeletons》.Electric Literature of C8H7BrO2 The article contains the following contents:

A palladium-catalyzed tandem carbonylative lactonization and Diels-Alder cycloaddition reaction between aldehyde-tethered benzyl halides I (R1 = H, X = Cl, Br; R1 = 4-Cl, 3-Br, 5-MeO, etc., X = Br) and alkenes R2R3C:CHR4 [R2 = H, n-BuO, ClCH2CH2O, BocNH, Ph, 2-MeC6H4, 4-ClC6H4, etc., R3 = R4 = H; R2 = Ph, R3 = Me, R4 = H; R2R4 = OCH2CH2, (CH2)3, (CH2)6; etc.] has been developed. A range of alkenes and aldehyde-tethered benzyl halides bearing different substituents can be successfully transformed into the corresponding bridged polycyclic compounds II in good yields. This strategy provides a unique approach to complex lactone-containing bridged polycyclic compounds In the part of experimental materials, we found many familiar compounds, such as 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Electric Literature of C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Electric Literature of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yu, Mingming; Gao, Yuhan; Zhang, Lin; Zhang, Yingjie; Zhang, Yiyan; Yi, Hong; Huang, Zhiliang; Lei, Aiwen published an article in Green Chemistry. The title of the article was 《Electrochemical-induced benzyl C-H amination towards the synthesis of isoindolinones via aroyloxy radical-mediated C-H activation》.Category: bromides-buliding-blocks The author mentioned the following in the article:

A novel electrochem. strategy to selectively and sustainably access isoindolinones I [R1 = H, 7-Me, 5-F, etc.; R2 = H, Me, Et, n-Pr, i-Pr, n-Bu; R3 = Me, n-Pr, i-Pr, n-Bu, cyclopropyl, CD3] using simple o-alkyl benzoic acids and nitriles as substrates under metal catalyst and external oxidant-free conditions was developed. Meanwhile, nitrile as the nitrogen source plays a vital role, as its derived intermediate facilitates the construction of the amide bond in the product. Mechanistic investigations suggest that aroyloxy radicals were involved in this transformation, which initiated the benzylic C-H amination event by a 1,5-HAT process. The protocol showed a very good functional group tolerance.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Category: bromides-buliding-blocks) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2012,Ueno, Satoshi; Komiya, Sadakazu; Tanaka, Takeshi; Kuwano, Ryoichi published 《Intramolecular SN’-Type Aromatic Substitution of Benzylic Carbonates at their Para-Position》.Organic Letters published the findings.Category: bromides-buliding-blocks The information in the text is summarized as follows:

The benzylic carbonates, which connect with an active methine through an o-phenylene tether at their meta-position, are cyclized by Pd(η3-C3H5)Cp-S-Phos catalyst, yielding 3-methyl-9,10-dihydrophenanthrenes, e.g., I. In the catalytic cyclization, the internal nucleophile attacks not the ortho-carbon but the para-carbon of the benzylic ester. The [3 + 2] cycloaddition of m-(silylmethyl)benzyl carbonates with alkylidene malonates was developed from the palladium-catalyzed intramol. SN’-type aromatic substitution. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Category: bromides-buliding-blocks)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Ligand-Enabled Pd(II)-Catalyzed C(sp3)-H Lactonization Using Molecular Oxygen as Oxidant》 was written by Qian, Shaoqun; Li, Zi-Qi; Li, Minyan; Wisniewski, Steven R.; Qiao, Jennifer X.; Richter, Jeremy M.; Ewing, William R.; Eastgate, Martin D.; Chen, Jason S.; Yu, Jin-Quan. Synthetic Route of C8H7BrO2 And the article was included in Organic Letters in 2020. The article conveys some information:

Pd(II)-catalyzed C-H lactonization of o-Me benzoic acid substrates has been achieved using mol. oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct biol. important benzolactone scaffolds. The use of a gas mixture of 5% oxygen in nitrogen demonstrated the possibility for its application in pharmaceutical manufacturing In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Synthetic Route of C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Synthetic Route of C8H7BrO2 Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Hu, Xiao-Qiang; Hu, Zhiyong; Zhang, Guodong; Sivendran, Nardana; Goossen, Lukas J. published 《Catalytic C-N and C-H Bond Activation: ortho-Allylation of Benzoic Acids with Allyl Amines》.Organic Letters published the findings.Recommanded Product: 76006-33-2 The information in the text is summarized as follows:

A facile insertion of ruthenium into aromatic C-H and allylic C-N bonds are the key steps in a [Ru(p-cymene)Cl2]2-catalyzed ortho-C-H allylation of benzoic acids. This protocol allows drawing on the large pool of allylic amines for state-of-the-art ortho-functionalizations of arenes I (R = 2-Et, 2-F, 3-Me, etc.), turning neutral amines into leaving groups. Concise syntheses of biol. active compounds provide further evidence of the synthetic potential of this methodol. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Recommanded Product: 76006-33-2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhu, Peiyu; Zhang, Jian; Yang, Yifei; Wang, Lixun; Zhou, Jinpei; Zhang, Huibin published an article in Molecular Diversity. The title of the article was 《Design, synthesis and biological evaluation of isoxazole-containing biphenyl derivatives as small-molecule inhibitors targeting the programmed cell death-1/ programmed cell death-ligand 1 immune checkpoint》.HPLC of Formula: 76006-33-2 The author mentioned the following in the article:

Monoclonal antibodies targeting the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) immune checkpoint have achieved enormous success in cancer immunotherapy. But the antibody-based immunotherapies carry a number of unavoidable deficiencies such as poor pharmacokinetic properties and immunogenicity. Small-mol. PD-1/PD-L1 inhibitors offer the superiority of complementarity with monoclonal antibodies and represent an appealing alternative. A novel series of isoxazole-containing biphenyl compounds were designed, synthesized and evaluated as PD-1/PD-L1 inhibitors in this paper. The structure-activity relationship of the novel synthesized compounds indicated that the ring-closure strategy of introducing isoxazole could be employed and the 3-cyanobenzyl group was significant for the inhibitory activity against the PD-1/PD-L1 protein-protein interactions. Mol. docking studies were performed to help understand the binding mode of the small-mol. inhibitor with the PD-L1 dimer. In particular, compound II-12 was a promising anti-PD-1/PD-L1 inhibitor with the IC50 value of 23.0 nM, providing valuable information for future drug development. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. HPLC of Formula: 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary