Category: 74896-66-5

An, Peng published the artcileSterically Shielded, Stabilized Nitrile Imine for Rapid Bioorthogonal Protein Labeling in Live Cells, Recommanded Product: Methyl 3,5-dibromo-4-methylbenzoate, the main research area is stabilized nitrile imine bioorthogonal protein labeling mammalian cell.

In pursuit of fast bioorthogonal reactions, reactive moieties have been increasingly employed for selective labeling of biomols. in living systems, posing a challenge in attaining reactivity without sacrificing selectivity. To address this challenge, here the authors report a bioinspired strategy in which mol. shape controls the selectivity of a transient, highly reactive nitrile imine dipole. By tuning the shape of structural pendants attached to the ortho position of the N-aryl ring of diaryltetrazoles, precursors of nitrile imines, the authors discovered a sterically shielded nitrile imine that favors the 1,3-dipolar cycloaddition over the competing nucleophilic addition The photogenerated nitrile imine exhibits an extraordinarily long half-life of 102 s in aqueous medium, owing to its unique mol. shape that hinders the approach of a nucleophile as shown by DFT calculations The utility of this sterically shielded nitrile imine in rapid (∼1 min) bioorthogonal labeling of glucagon receptor in live mammalian cells was demonstrated.

Journal of the American Chemical Society published new progress about 1,3-Dipolar cycloaddition reaction. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Recommanded Product: Methyl 3,5-dibromo-4-methylbenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Amano, Taisei published the artcileNew Strategy for Synthesis of Bis-Pocket Metalloporphyrins Enabling Regioselective Catalytic Oxidation of Alkanes, Application of Methyl 3,5-dibromo-4-methylbenzoate, the main research area is metalloporphyrin ruthenium double pocket preparation oxidation catalyst; alkane oxidation preparation alkanol alkanone ruthenium metalloporphyrin double pocket.

Meso-Quaterphenyl-substituted metalloporphyrins (bis-pocket porphyrins) were prepared; the ruthenium porphyrin undergoes oxidation to dioxoruthenium species, which catalyze oxidation of alkanes by pyridine N-oxides into alkanols and alkanones,. Cytochrome P 450 selectively hydroxylates the ω and ω-1 positions of fatty acids. Among synthetic oxidizing catalysts, Suslick’s bis-pocket porphyrin Mn or Fe complex achieved ω oxidation for the first time, but the yield in the preparation of the catalyst was poor due to steric hindrance, and in addition, the catalyst turnover number in the oxidation reaction was low. We have devised a new synthetic strategy involving the introduction of eight bulky aryl groups at the 2,6-positions of the meso-Ph groups after construction of the porphyrin skeleton. This strategy greatly improved the yield in synthesis of the catalyst, and a number of derivatives of bis-pocket porphyrin and their metal complexes were prepared These Ru complexes show unique ω-1 selectivity and provide a much higher turnover number in the oxidation of linear alkane with 2,6-dichloropyridine N-oxide, as compared to the reaction catalyzed by conventional Ru porphyrins.

Bulletin of the Chemical Society of Japan published new progress about Aliphatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Application of Methyl 3,5-dibromo-4-methylbenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary