Category: 74896-66-5

Manchand, Percy S. published the artcileA convenient synthesis of 3,5-dimethoxy-4-methylbenzoic acid, Product Details of C9H8Br2O2, the main research area is benzoic acid dimethoxymethyl; bromination toluic acid; methoxylation methyldibromobenzoate.

4-MeC6H4CO2Me, prepared in 95% yield from 4-MeC6H4CO2H, was stirred with AlCl3 and Br at room temperature 30 min and then at 80-8° 1 h to give 65% 3,5,4-Br2MeC6H2CO2Me (I). Treating I in pyridine with NaOMe in the presence of CuCl gave 81% 3,5,4-(MeO)2MeC6H2CO2Me, which was hydrolyzed to the title acid.

Synthesis published new progress about Methoxylation. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Product Details of C9H8Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stelmach, John E. published the artcileDesign and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase, HPLC of Formula: 74896-66-5, the main research area is phenyl piperidinyl piperazino dichlorophenylquinazolinone preparation p38 MAP kinase inhibitor; chlorophenylquinazolinone piperidinyl piperazino preparation p38 MAP kinase inhibition pharmokinetic; piperidinylchlorofluorophenylquinazolinone tertbutyl preparation inhibitor p38 MAP kinase TNF; dichlorophenylquinazolinone preparation p38 MAP kinase inhibitor; quinazolinone dichlorophenyl preparation p38 MAP kinase inhibitor; human TNF alpha production inhibition chlorofluorophenylquinazolinone.

The development of potent, orally bioavailable (in rat) and selective dihydroquinazolinone inhibitors I (R = CO2Me, R1 = H, Br, 2-FC6H4, etc.; R = OMe, R1 = 2-Cl-4-FC6H3, 2,4-F2C6H3, 2-ClC6H4), II (R1 = 2-Cl-4-FC6H3, 2,4-F2C6H3, 2-ClC6H4, X = none, O, NH, CH2, CO, Y = CH, N) and III (R2 = Me, Et, CHMe2, etc.) of p38α MAP kinase is described. For example, III (R2 = CMe3) was prepared via the Still coupling of I (R = OSO2CF3, R1 = 2-Cl-4-FC6H3) with 1-tert-butyl-4-(trimethylstannyl)-1,2,3,6-tetrahydropyridine. These analogs are hybrids of a pyridinylimidazole p38α inhibitor reported by Merck Research Laboratories and VX-745. Optimization of the C-5 Ph and the C-7 piperidinyl substituents led to the identification of III (R2 = CMe3) which gave excellent suppression of TNF-α production in LPS-stimulated whole blood (IC50=10 nM) and good oral exposure in rats (F=68%, AUCn PO=0.58 μM h).

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, HPLC of Formula: 74896-66-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Saeed, Aamer published the artcileMethyl 3,5-dibromo-4-methylbenzoate, Safety of Methyl 3,5-dibromo-4-methylbenzoate, the main research area is methyl dibromo methylbenzoate ester crystal structure; mol structure methyl dibromomethylbenzoate ester; weak hydrogen bond methyl dibromomethylbenzoate ester.

In the title compound, C9H8Br2O2, the mol. is essentially planar with an r.m.s. deviation of 0.0652 Å from the mean plane through all non-H atoms and a dihedral angle of 7.1 (2)° between the benzene ring plane and the carboxylate substituent. In the crystal structure, weak C-H…Br hydrogen bonds and weak intermol. O…Br contacts [3.095 (2) Å], link adjacent mols. into layers parallel to (102). Addnl. weak intermol. C-H…O hydrogen bond interactions stack the layers above and below the mol. plane and down the a axis. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Bromination. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Safety of Methyl 3,5-dibromo-4-methylbenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quan, Cui published the artcileSynthesis of carbon nanotubes and porous carbons from printed circuit board waste pyrolysis oil, HPLC of Formula: 74896-66-5, the main research area is synthesis porous carbon printed circuit board waste pyrolysis oil; carbon nanotube synthesis printed circuit board waste pyrolysis oil.

The possibility and feasibility of using pyrolysis oil from printed circuit board (PCB) waste as a precursor for advanced carbonaceous materials is presented. The PCB waste was 1st pyrolyzed in a laboratory scale fixed bed reactor at 600° to prepare pyrolysis oil. The anal. of pyrolysis oil by gas chromatog.-mass spectroscopy indicated that it contained a very high proportion of phenol and phenol derivatives It was then polymerized in formaldehyde solution to synthesize pyrolysis oil-based resin which was used as a precursor to prepare C nanotubes (CNTs) and porous carbons. SEM and transmission microscopy investigation showed that the resulting CNTs had hollow cores with outer diameter of ∼338 nm and wall thickness of ∼86 nm and most of them were filled with metal nanoparticles or nanorods. X-ray diffraction reveals that CNTs have an amorphous structure. N adsorption isotherm anal. indicated the prepared porous carbons had a Brunauer-Emmett-Teller surface area of 1214 m2/g. The mechanism of the formation of the CNTs and porous carbons is discussed.

Journal of Hazardous Materials published new progress about Carbon nanotubes. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, HPLC of Formula: 74896-66-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rice, Kenneth D. published the artcilePyrazolopyrimidines as dual Akt/p70S6K inhibitors, SDS of cas: 74896-66-5, the main research area is pyrazolopyrimidine preparation Akt p70S6K inhibitor SAR.

Activation of the PI3K/Akt/mTOR kinase pathway is frequently associated with human cancer. Selective inhibition of p70S6 Kinase, which is the last kinase in the PI3K pathway, is not sufficient for strong tumor growth inhibition and can lead to activation of upstream proteins including Akt through relief of a neg. feedback loop. Targeting multiple sites in the PI3K pathway might be beneficial for optimal activity. In this manuscript we report the design of dual Akt/p70S6K inhibitors and the evaluation of the lead compound 11b (I) in vivo, which was eventually advanced into clin. development.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, SDS of cas: 74896-66-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tuxen, Jens published the artcileHighly Fluorous Porphyrins as Model Compounds for Molecule Interferometry, Recommanded Product: Methyl 3,5-dibromo-4-methylbenzoate, the main research area is porphyrin perfluoroalkyl preparation quantum interference.

The synthesis and characterization of seven tailor-made highly fluorous porphyrin derivatives are described, as large perfluoroalkyl-functionalized organic mols. are the most complex objects for which the quantum wave nature has been observed so far. We have found, in particular, that tetrakis(pentafluorophenyl)porphyrin is a suitable starting point for a modular synthesis that is geared towards porphyrin derivatives with many peripheral fluorous chains. This allows us to tailor and optimize the sublimation features of these compounds for mol. interferometry. We have analyzed the evaporation process of one member of the series by determining the enthalpy of evaporation, as the creation of a sufficiently intense, slow mol. beam is crucial for quantum interference experiments We present the quantum fringe pattern of a second member of the series, which we could obtain in a Kapitza-Dirac-Talbot-Lau interferometer.

European Journal of Organic Chemistry published new progress about Evaporation enthalpy. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Recommanded Product: Methyl 3,5-dibromo-4-methylbenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kelly, Martha J. published the artcileDiscovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia, Related Products of bromides-buliding-blocks, the main research area is tetrahydrotriazinecarbonitrile derivative MGL3196 thyroid hormone receptor agonist dyslipidemia treatment.

The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). A pyridazinone series has been identified that is significantly more THR-β selective than earlier analogs. Optimization of this series by the addition of a cyanoazauracil substituent improved both the potency and selectivity and led to MGL-3196 (53), which is 28-fold selective for THR-β over THR-α in a functional assay. Compound 53 showed outstanding safety in a rat heart model and was efficacious in a preclin. model at doses that showed no impact on the central thyroid axis. In reported studies in healthy volunteers, 53 exhibited an excellent safety profile and decreased LDL cholesterol (LDL-C) and triglycerides (TG) at once daily oral doses of 50 mg or higher given for 2 wk.

Journal of Medicinal Chemistry published new progress about Anticholesteremic agents. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Hui-Yan published the artcileAssembly of Two Metal-Organic Frameworks Based on Distinct Cobalt Dimeric Building Blocks Induced by Ligand Modification: Gas Adsorption and Magnetic Properties, Related Products of bromides-buliding-blocks, the main research area is cobalt pyridinylbenzoate preparation porosity gas adsorption enthalpy antiferromagnetic exchange; crystal structure cobalt pyridinylbenzoate dimeric building block MOF.

Solvothermal reaction of 3,5-di(pyridin-4-yl)benzoic acid (HDPB) with Co(II) leads to a novel metal-organic framework, [Co2O(DPB)2(DMF)2]·xS (1), which represents a rare reo-type net with trigonal prismatic Co dimer, [Co2O(CO2)2N4] as building blocks to construct a 3-dimensional framework containing three different types of nanoscale M12L12 and M24L12 polyhedron cages. More interestingly, under the same condition, the assembly of 4-methyl-3,5-di(pyridin-4-yl)benzoic acid (HMDPB) with Co(II) facilitates the formation of a cationic framework, [Co2(MDPB)3(DMF)](NO3)·xS (2), with Co dimer, [Co2(CO2)3N4], as building blocks. Complex 2 represents the 1st example of a zeolite-like network with 48-nuclear SOD cage. The significant effect of subtle modification of ligand on the overall MOFs is discussed. Also, the gas adsorption studies reveal that 1 exhibits permanent porosity and selective CO2 uptake. Variable-temperature magnetic susceptibility measurements show that both 1 and 2 exhibit antiferromagnetic behavior.

Inorganic Chemistry published new progress about Adsorption enthalpy, isosteric. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huo, Zhaohui published the artcileCopolymeric films obtained by electropolymerization of porphyrins and dipyridyl-spacers including Dawson-type polyoxometalates, Product Details of C9H8Br2O2, the main research area is polyoxometalate porphyrin copolymer electropolymerization oxidation reduction potential.

This paper reports the formation of hybrid polyoxometalate-porphyrin copolymeric films obtained by the electro-oxidation of zinc-β-octaethylporphyrin (ZnOEP) in the presence of a functionalized Dawson-type polyoxometalate bearing two pyridyl groups (POMdbme3,3, Py-POM-Py) which will be compared to the copolymer obtained from ZnOEP and a dipyridyl compound without POM (ibme3,3). The resulting film has been characterized by UV-visible absorption spectroscopy, XPS, and at. force microscopy. Electrochem. quartz crystal microbalance was employed to investigate the poly-porphyrin-POMs deposition mass.

Journal of Solid State Electrochemistry published new progress about Electrochemical polymerization. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Product Details of C9H8Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lai, Holden W. H. published the artcileFunctionalized Rigid Ladder Polymers from Catalytic Arene-Norbornene Annulation Polymerization, Recommanded Product: Methyl 3,5-dibromo-4-methylbenzoate, the main research area is ladder polymer arene norbornene annulation polymerization.

Rigid ladder polymers represent a unique polymer architecture but have limited synthetic accessibility and structural diversity. Using catalytic arene-norbornene annulation (CANAL) polymerization, we synthesized ladder polymers consisting of rigid and kinked norbornyl benzocyclobutene backbones and bearing various functional groups, such as alc., amine, ester, carbamate, amide, benzyl bromide, azide, and heterocycles. The incorporation of functional groups was achieved by either copolymerization of functionalized ladder-type dinorbornenes or postpolymn. functionalization. Functionalization of ladder polymers allows modification of their solubility, compatibility, and other properties, expanding their utilities. These ladder polymers remain microporous and highly glassy, which are desirable for separation and high-temperature applications.

ACS Macro Letters published new progress about Cyclization (polymerization). 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Recommanded Product: Methyl 3,5-dibromo-4-methylbenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary