Application of 73908-04-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 73908-04-0 as follows.
General procedure: An oven-dried Schlenk tube containing a stirring bar was charged with NiI2 (2.5-10.0 mol%), L1 (4.4-17.6 mol%) and Mn powder (3 equiv.). The Schlenk tube was then evacuated and back-filled under a CO2 flow (this sequence was repeated three times) and finally an atmospheric pressure of CO2 was established. The corresponding alkyl bromide (0.5 mmol) and DMF (1 M) were added under a CO2 flow. Once added, the Schlenk tube was closed at atmospheric pressure of CO2 (1 atm) and stirred at the desired temperature for 20-48 h. The mixture was then carefully quenched with 2 M HCl to hydrolyse the resulting carboxylate and extracted with EtOAc (three times). The combined organic layer was washed with brine (three times), dried over anhydrous MgSO4, filtrated and evaporated. The resulting crude carboxylic acid was purified by conventional flash chromatography in silica gel using hexanes/EtOAc 3:1 with 1% formic acid.
According to the analysis of related databases, 73908-04-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Julia-Hernandez, Francisco; Moragas, Toni; Cornella, Josep; Martin, Ruben; Nature; vol. 545; 7652; (2017); p. 84 – 88;,
Bromide – Wikipedia,
bromide – Wiktionary