Category: 7314-86-5

Reference of 7314-86-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7314-86-5 name is 1,3,5,7-Tetrabromoadamantane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A 250 ml three-necked flask equipped with a condenser was charged with 5.0 g (ie, 11. Ommol) of tetrabromoadamantane and 20 mL (ie, leOmmol) of o-methoxybromobenzene. An inverted funnel was pipetted from the upper end of the condenser to a 30% NaOH aqueous solution to absorb the HBr produced by the reaction. Under 5 C cold water bath, 1.2g (S Jie 4.5mmol) of AlBr3 was added to the reaction system, and the reaction was continued under a cold water bath for 1 hour, then the cold water bath was withdrawn and the reaction was resumed to room temperature for about 3 hours. Finally, the reaction system In the oil bath was heated to 60 C for 4 hours, the reaction was cooled to room temperature, poured into 100mL of acidic ice water and stirred lh.After the ice has completely melted, 100 ml of ethyl acetate is added to the mixture for extraction. The organic layer is washed with water until neutral, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and the filtrate is concentrated. The concentrated solution is then slowly added dropwise to 100 ml Methanol, precipitation, to give a pale yellow solid 6.9g, 72% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3,5,7-Tetrabromoadamantane, and friends who are interested can also refer to it.

Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Chen Jinping; Li Yi; Yu Tianjun; Zeng Yi; (20 pag.)CN107324978; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 7314-86-5,Some common heterocyclic compound, 7314-86-5, name is 1,3,5,7-Tetrabromoadamantane, molecular formula is C10H12Br4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 250ml three-necked flask equipped with a condenser tube5.0 g (ie 11.0 mmol) of tetrabromoadamantane and20 mL (ie, 165 mmol) of m-dibromobenzene,Condenser duct from the upper end connected to an inverted funnel 30% NaOH aqueous solution,To absorb the HBr produced by the reaction.Cold water bath at 5 ,To the reaction system was added 1.2g (ie, 4.5mmol) of AlBr3, stirring was continued under a cold water bath for 1 hour,Then remove the cold water bath,Return to room temperature for about 3 hours,The final reaction system was heated in an oil bath to 60 C for 4 hours,The reaction solution was cooled to room temperature,Pour into 100 mL of acidic ice water and stir for 1 h.After the ice is completely melted, 100 ml of methylene chloride is added to the mixture for extraction. The organic layer is washed with water until neutral, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and the filtrate is concentrated. The concentrated solution is then slowly added dropwise to 100 ml Methanol, precipitation,9.31 g of a pale yellow solid was obtained in a yield of 79%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3,5,7-Tetrabromoadamantane, its application will become more common.

Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Chen Jinping; Li Yi; Yu Tianjun; Zeng Yi; (18 pag.)CN107266319; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 7314-86-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7314-86-5, name is 1,3,5,7-Tetrabromoadamantane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1,3-dibromobenzene (70 mL) was added to a mixture of 1,3,5,7-tetrabromoadamantane (5.0 g, 11.1 mmol) and AlCl3 powder (4.0 g,30.0 mmol), at 0 C. The mixture was then stirred at ambient temperaturefor 36 h. After quenching the reaction by adding ice water, theorganic layer was diluted with chloroform and filtered. The filtrate waswashed with deionised water and brine and then dried over magnesiumsulfate. After evaporation to remove volatiles, 1,3,5,7-tetrakis(1,3-bibromophenyl)adamantane was obtained as a white solid from thecrystallization in chloroform (9.6 g, 81% yield). 1H NMR (DMSO-d6,400 MHz): delta (ppm) 7.80 (s, 8H), 7.69 (s, 4H), 2.05 (s, 12H); 13C NMR(CDCl3-d3, 400 MHz): delta (ppm) 150.7, 131.5, 126.2, 122.4, 45.3, 38.3.Anal. Calcd for C34H24Br8: C, 38.10; H, 2.26; Found: C, 38.11; H, 2.21.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3,5,7-Tetrabromoadamantane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Xiong; Guo, Jianwei; Tong, Rui; Topham, Paul D.; Wang, Jiawei; Reactive and functional polymers; vol. 130; (2018); p. 126 – 132;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 7314-86-5,Some common heterocyclic compound, 7314-86-5, name is 1,3,5,7-Tetrabromoadamantane, molecular formula is C10H12Br4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound (1) of Example Ia was reacted with sodium cyanide in DMSO under irradiation at 254 nm as described in G. S. Lee et al., Org. Lett. Vol. 6, No. 11, 2004, 1705-1707, scheme 2a, (c). Tetracyanoadamantane was obtained in 63% yield.

The synthetic route of 7314-86-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GE HEALTHCARE AS; WO2009/21948; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary