Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73096-42-1, name is 5-(2-Bromophenyl)tetrazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H5BrN4
A suspension of [5-(2-BROMOPHENYL)-1 H-TETRAZOLE (4.] 50 [G] ; 20.0 [MMOL)] in ter-butyl methyl ether (40 ml) is warmed to [45C] and [METHANESULFONIC] acid (0.058 [G ;] 0.60 [MMOL)] is added. A solution of 3,4-dihydro-2H-pyran (1.90 ml ; 21 [MMOL)] in tert-butyl methyl ether (21 ml) is added to the resulting mixture over 1 hour at [45C.] The mixture is further stirred for 6 hours at [45C.] The resulting solution is cooled to about [0C] and a solution of sodium hydrogencarbonate (2.4 [G)] in water (30 ml) is added. The aqueous phase is separated and extracted with ter-butyl methyl ether (10 [ML).] The combined organic phases are washed twice with a 1 N KOH solution (10 mi each) and once with a solution of 10 weight-% of sodium chloride in water (10 ml). The resulting organic phase is dried over anhydrous sodium sulfate, filtered and evaporated in vacuo to afford a mixture of [5- (2-BROMOPHENYL)-2-] [(TETRAHYDROPYRAN-2-YL)-2H-TETRAZOLE (N2-ISOMER)] and [5- (2-BROMOPHENY))-1- (TETRAHYDROPYRAN-] [2-YL)-1 H-TETRAZOLE (N1-ISOMER)] in a ratio of about 93: 7 (according [TO 1H-NMR) aS AN ORANGE] oil. 1H-NMR of N2-isomer [(400] MHz, CDCI3) : 1.72-1. 85 [(M,] 3 H), 2.18-2. 26 (m, 2 H), 2.45-2. 54 (m, 1 H), 3.80-3. 86 (m, 1 H), 4.01-4. [07] (m, 1 H), 6.12-6. 15 (m, 1 H), 7.31-7. 35 (m, [1] H), 7.41-7. 45 (m, [1] H), 7.73-7. 75 (m, 1 H), [7 :] 87-7.90 (m, 1 H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 73096-42-1.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/26847; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary