Pirrung, Michael C. published the artcile19F-Encoded Combinatorial Libraries: Discovery of Selective Metal Binding and Catalytic Peptoids, Recommanded Product: 3-Bromo-2-fluoro-5-methylbenzoic acid, the main research area is aryl fluoride preparation labeling solid support combinatorial chem; fluorine 19 encoded combinatorial peptoid library solid phase synthesis; metal binding screening combinatorial peptoid library; acylation autocatalyst screening combinatorial peptoid library; amine cyclic anhydride coupling solid phase combinatorial library.
A 19F NMR method for encoding of combinatorial libraries has been developed. Aryl fluorides whose chem. shifts are modified by aromatic substituents were prepared and attached to resin support beads that were used in the split-pool synthesis of peptoids. The detection of the 19F NMR signal of tags derived from a single “”big bead”” was demonstrated. The library diversity arises from amines and the cyclic anhydrides used in their acylation. The resulting 90-compound library was examined for metal ion binding, whereupon novel ligands for iron and copper were discovered. The metal-binding constants of some of these peptoids were in the low micromolar range. The library was also examined for catalysis of self-acylation.
Journal of Combinatorial Chemistry published new progress about Amines Role: CMB (Combinatorial Study), RCT (Reactant), RACT (Reactant or Reagent). 72518-16-2 belongs to class bromides-buliding-blocks, name is 3-Bromo-2-fluoro-5-methylbenzoic acid, and the molecular formula is C8H6BrFO2, Recommanded Product: 3-Bromo-2-fluoro-5-methylbenzoic acid.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary