Synthetic Route of 716320-92-2,Some common heterocyclic compound, 716320-92-2, name is 5,6-Dibromo-1H-benzo[d][1,2,3]triazole, molecular formula is C6H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of IPrAuCl (6.2 mg, 0.01 mmol) and AgNTf2 (4 mg, 0.01 mmol) in 1,2-dichloroethane (3 mL), was added o-alkynylarylazide 1a (43.8 mg, 0.2 mmol) and benzotriazole 2a (95 mg, 0.8 mmol) stepwisely at rt. The reaction mixture was stirred at 80 C with TLC monitoring until complete consumption of the starting material 1a (48 h). Concentration of the reaction mixture, followed by purification through flash chromatography (petroleum/EtOAc = 5/1 as the eluent) afforded 3a (38 mg) and 3a (8.5 mg) as two yellow solid products (75 % total yield, 3a/3a=4.5/1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Dibromo-1H-benzo[d][1,2,3]triazole, its application will become more common.
Reference:
Article; Chen, Bai-Ling; Chen, Zili; Li, Tao; Zhu, Li-Li; Tetrahedron Letters; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary