Category: 7073-94-1

Adding a certain compound to certain chemical reactions, such as: 7073-94-1, name is 1-Bromo-2-isopropylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7073-94-1, Product Details of 7073-94-1

General procedure: In the oven dried flask 1-Boc-piperazine (3 g, 16.12 mmol), Pd2(dba)3 (0.25 g, 0.27 mmol), BINAP (0.34 g, 0.08 mmol), sodium tert-butoxide (1.62 g, 18.82 mmol) were solubilized in toluene (8mL) in inert atmosphere. After 10 min a solution of 2-bromo-1,1?-biphenyl (1.14 ml, 6.72 mmol) in toluene (2 mL) was added and the reaction was heated up to 100 C and stirred overnight. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate and filtered through the pad of celite. The solution was then concentrated under reduced pressure. Product was purified using column chromatography on silica gel with AcOEt/petroleum ether = 1/9 (v/v) as eluting system. To give 1.5 g (70%) of tert-butyl 4-([1,1′-biphenyl]-2-yl)piperazine-1-carboxylate which was then subjected to the Boc deprotection reaction according to protocol described above to yield 1.13 g (100%) of 1-([1,1′-biphenyl]-2-yl)piperazine as a free base.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-isopropylbenzene, and friends who are interested can also refer to it.

Reference:
Article; Canale, Vittorio; Kurczab, Rafaa; Partyka, Anna; SataAa, Grzegorz; Witek, Jagna; Jastrzaebska-Wiaesek, Magdalena; Pawaowski, Maciej; Bojarski, Andrzej J.; WesoAowska, Anna; Zajdel, Pawea; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 202 – 211;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 7073-94-1, name is 1-Bromo-2-isopropylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7073-94-1, name: 1-Bromo-2-isopropylbenzene

1-Bromo-2-isopropylbenzene (15.0 g, 75.3 mmol),4-chlorophenylboronic acid (14.1 g, 90.4 mmol),Tetrakistriphenylphosphine palladium (1.74 g, 1.51 mmol),Potassium carbonate (20.8 g, 151 mmol),Tetrabutylammonium bromide 4.86 g, 15.1 mmol),Toluene (80mL),Ethanol (80 mL) and deionized water (80 mL) were added to a round bottom flask.Raise to 75-80 C under nitrogen atmosphere and stir for 16 hours;The reaction solution was cooled to room temperature, and toluene (150 mL) was added for extraction.The organic phases were combined, dried over anhydrous magnesium sulfate and filtered.The solvent is removed under reduced pressure;The obtained crude product was recrystallized and purified using a dichloromethane/n-heptane system.Intermediate I-B-1 (7.89 g, 45%) was obtained as a yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-isopropylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanxi Laite Optoelectric Materials Co., Ltd.; Ma Tiantian; Feng Zhen; Li Hongyan; Li Jian; Sha Xunshan; (37 pag.)CN110105225; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7073-94-1, name is 1-Bromo-2-isopropylbenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H11Br

n-Butyl lithium (1.45 mL, 3.63 mmol, 2.5 M in hexane) was added dropwise to a solution of 1-bromo-2-isopropylbenzene (678 mg, 3.41 mmol) in dry diethyl ether (10 mL) at 0 C. The colorless solution was warmed to room temperature and stirred for 3 h. Then, the solution was added dropwise to a dry diethyl ether (5 mL) solution of compound B (434 mg, 1.14 mmol) at -78 C. The yellow solution was warmed to room temperature and stirred for 30 min. The color turned to red. The reaction was followed by TLC and then quenched with NH4Cl (aq) at 0 C. The organic phase was separated and reserved. The aqueous phase was extracted with diethyl ether (3 ¡Á 30 mL). The combined organic phases were washed with water (2 ¡Á 30 mL) and brine (1 ¡Á 30 mL). The organic phase was dried over Na2SO4. The solvent was distilled off by rotary evaporation. The crude product was purified by flash column chromatography on silica gel using hexane/diethyl ether (20/1) as eluent. The product was isolated as a yellow solid (120 mg, yield: 88%). 1H NMR (400 MHz, CDCl3, 25 C): 0.96 (9H, CH(CH3)2), 0.98 (3H, d, J = 6.8 Hz, CH(CH3)2), 1.05 (6H, d, J = 6.8 Hz, CH(CH3)2), 2.89 (2H, sept, CH(CH3)2), 3.02 (1H, sept, CH(CH3)2), 4.19 (1H, br, NH), 5.52 (1H, s, NCH), 6.96 (2H, m, Ar-H), 7.07 (3H, s, Ar-H), 7.11 (1H, d, J = 1.2 Hz, Ar-H), 7.21 (1H, m, Ar-H), 7.28-7.39 (3H, m, Ar-H), 7.37 (1H, d, J = 7.6 Hz, Py-H), 7.57-7.64 (3H, m, Ar-H), 7.68-7.71 (1H, m, Ar-H), 8.97 (1H, s, indole-NH). 13C NMR (100.62 MHz, CDCl3, 25 C): delta = 23.97, 24.01, 24.05, 24.30, 28.00, 28.82, 66.18, 100.43, 111.54, 117.97, 119.74, 120.26, 121.33, 123.27, 123.63, 123.71, 125.81, 126.17, 127.47, 127.72, 129.31, 136.45, 136.87, 137.30, 139.43, 137.30, 139.43, 142.56, 142.96, 146.56, 149.53, and 162.48.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Li, Gang; Lamberti, Marina; Mazzeo, Mina; Pappalardo, Daniela; Pellecchia, Claudio; Journal of Molecular Catalysis A: Chemical; vol. 370; (2013); p. 28 – 34;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7073-94-1, name is 1-Bromo-2-isopropylbenzene, A new synthetic method of this compound is introduced below., Computed Properties of C9H11Br

1-Br-2-isopropylbenzene (1.306 g, 6.561 mmol, 2.7 eq)Was added THF (13.122 mL) and t-BuLi (8.36 mL) was added at -78 C. This was reacted for 2 hours and then heated to room temperature to prepare lithium cumene. The ligand precursor prepared above N-(2,6-diisopropylphenyl)-1-(6-(2-methyl-1,2,3,4-tetrahydroquinolin-8-yl)pyridin-2-yl)methanimine(1 g, 2.43 mmol, 1 eq) was added diethyl ether (24.3 mL), and the lithium cumene was added dropwise at -78 C. The reaction was allowed to warm to room temperature overnight, quenched with 1 N NH4Cl and worked up with Ether / H2O. The water was dried with Na2SO4 and the solvent was vacuum dried with a rotary evaporator. Yellow oil, 1.48 g, was obtained in quantitative yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LG Chemical Co., Ltd.; Han, Hyo Jung; Han, Ki Won; Jang, Jae Kwon; Lee, Eun Jung; Lee, Chung Hoon; (59 pag.)KR2017/95036; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary