7073-94-1 Archives - Page 7 of 9 - Bromides-buliding-blocks

Yabushita, Kenya’s team published research in Journal of the American Chemical Society in 2019 | CAS: 7073-94-1

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 7073-94-1 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

In 2019,Journal of the American Chemical Society included an article by Yabushita, Kenya; Yuasa, Akihiro; Nagao, Kazunori; Ohmiya, Hirohisa. Application of 7073-94-1. The article was titled 《Asymmetric Catalysis Using Aromatic Aldehydes as Chiral α-Alkoxyalkyl Anions》. The information in the text is summarized as follows:

We have developed a new umpolung strategy for catalytically forming a chiral α-alkoxyalkyl anion from an aromatic aldehyde for use in asym. synthesis. The reaction between aromatic aldehydes and aryl or allyl electrophiles with a silylboronate utilizing a chiral copper-N-heterocyclic carbene catalyst and a palladium-bisphosphine catalyst in a synergistic manner occurred with high enantioselectivities to deliver the three-component coupling products, chiral silyl-protected secondary alc. derivatives Our method features the catalytic generation of enantioenriched chiral α-alkoxyalkylcopper(I) intermediates from aldehydes and their subsequent palladium-catalyzed stereospecific cross-coupling. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Application of 7073-94-1)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cao, Lixin’s team published research in Macromolecules (Washington, DC, United States) in 2022 | CAS: 7073-94-1

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Related Products of 7073-94-1

In 2022,Cao, Lixin; Cai, Zhengguo; Li, Mingyuan published an article in Macromolecules (Washington, DC, United States). The title of the article was 《Phosphinobenzenamine Nickel Catalyzed Efficient Copolymerization of Methyl Acrylate with Ethylene and Norbornene》.Related Products of 7073-94-1 The author mentioned the following in the article:

A series of phosphinobenzenamine-based nickel complexes bearing substituted phenylphosphine ligands were synthesized and characterized. These nickel complexes combined with methylaluminoxane (MAO) exhibited very high activity (~106 g mol-1 h-1) and good thermal stability for norbornene polymerization The nickel catalysts were able to conduct copolymerization of norbornene and Me acrylate (MA) with high activity (3.76 x 105 g mol-1 h-1) to give high-mol.-weight functionalized cyclic olefin copolymer (COC) with reasonable MA incorporation (2.39-6.47 mol %). Moreover, the nickel catalysts also promote the copolymerization of ethylene and MA with moderate activity (~104 g mol-1 h-1) to produce semicrystalline high-mol.-weight polar functionalized polyethylene (PE). The MA incorporation in the copolymer was controlled in a wide range (up to 15.5 mol %). These complexes without any sterically bulky substituent on the ligand are distinctive examples of earth-abundant nickel complexes toward the direct copolymerization of ethylene or norbornene with the challenging vinyl polar monomer MA. The results came from multiple reactions, including the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Related Products of 7073-94-1)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Farizyan, Mirxan’s team published research in Journal of the American Chemical Society in 2021 | CAS: 7073-94-1

Farizyan, Mirxan; Mondal, Arup; Mal, Sourjya; Deufel, Fritz; van Gemmeren, Manuel published their research in Journal of the American Chemical Society in 2021. The article was titled 《Palladium-Catalyzed Nondirected Late-Stage C-H Deuteration of Arenes》.Computed Properties of C9H11Br The article contains the following contents:

Herein, palladium catalyzed nondirected late-stage deuteration of arenes is discussed. Key aspects include the use of D2O as a convenient and easily available deuterium source and the discovery of highly active N,N-bidentate ligands containing an N-acyl sulfonamide group. The reported protocol enables high degrees of deuterium incorporation via a reversible C-H activation step and features an extraordinary functional group tolerance, allowing for the deuteration of complex substrates. This is exemplified by the late-stage isotopic labeling of various pharmaceutically relevant motifs and related scaffolds. This method, among other applications, will prove useful as a tool in drug development processes and for mechanistic studies. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Computed Properties of C9H11Br)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Munday, Elizabeth S.’s team published research in Angewandte Chemie, International Edition in 2020 | CAS: 7073-94-1

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 1-Bromo-2-isopropylbenzene Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

《Isothiourea-Catalyzed Atropselective Acylation of Biaryl Phenols via Sequential Desymmetrization/Kinetic Resolution》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Munday, Elizabeth S.; Grove, Markas A.; Feoktistova, Taisiia; Brueckner, Alexander C.; Walden, Daniel M.; Young, Claire M.; Slawin, Alexandra M. Z.; Campbell, Andrew D.; Cheong, Paul Ha-Yeon; Smith, Andrew D.. Reference of 1-Bromo-2-isopropylbenzene The article mentions the following:

Nonracemic biaryldiol monoesters such as I were prepared by desymmetrization of racemic biaryldiols with isobutyric anhydride and diisopropylethylamine in CH2Cl2 in the presence of nonracemic imidazo- or pyrimidobenzothiazoles. The optimal catalyst depended on the substitution pattern of the biaryldiol. The kinetics of the reaction were determined to understand the enantioselectivity of the acylation; the observed enantioselectivity is a result of an enantioselective desymmetrization coupled to a chiroablative kinetic resolution The free energies and structures of potential transition states were determined using DFT calculations to understand the factors leading to high enantiocontrol; maintenance of substrate planarity to maximize a 1,5-S···O interaction within the key acyl ammonium intermediate is the major determinant of acylation selectivity and thus product enantioselectivity. In the experiment, the researchers used many compounds, for example, 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Reference of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 1-Bromo-2-isopropylbenzene Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Jingjing’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 7073-94-1

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.SDS of cas: 7073-94-1

In 2022,Li, Jingjing; Ye, Jianxun; Zhou, Jiayu; Li, Jing; Liu, Delong; Zhang, Wanbin published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《RuPHOX-Ru catalyzed asymmetric hydrogenation of α-substituted tetralones via a dynamic kinetic resolution》.SDS of cas: 7073-94-1 The author mentioned the following in the article:

The efficient RuPHOX-Ru catalyzed asym. hydrogenation of α-substituted tetralones via a dynamic kinetic resolution has been achieved for the synthesis of chiral tetrahydronaphthols. The mechanism study indicated that hydrogenation with H2 gas, rather than transfer hydrogenation with EtOH solvent as the hydrogen source, predominates in the reaction pathway. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-isopropylbenzene(cas: 7073-94-1SDS of cas: 7073-94-1)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rodriguez Castanon, Jesus’s team published research in Journal of Polymer Science, Part A: Polymer Chemistry in 2017 | CAS: 7073-94-1

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Safety of 1-Bromo-2-isopropylbenzene The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

In 2017,Rodriguez Castanon, Jesus; Sano, Natsuhiro; Shiotsuki, Masashi; Sanda, Fumio published 《Synthesis of poly(1-chloro-2-arylacetylene)s with high cis-content and examination of their absorption/emission properties》.Journal of Polymer Science, Part A: Polymer Chemistry published the findings.Safety of 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

A series of 1-chloro-2-arylacetylenes [Cl-CC-Ar, Ar = C6H5 (1), C6H4-p-iPr (2), C6H4-p-OiPr (3), C6H4-p-NHC(O)OtBu (4), and C6H4-o-iPr (5)] were polymerized using (tBu3P)PdMeCl/silver trifluoromethanesulfonate (AgOTf) and MoCl5/SnBu4 catalysts. The corresponding polymers [poly(1)-poly(5)] with weight-average mol. weights of 6500-690,000 were obtained in 10-91% yields. THF-insoluble parts, presumably high-mol. weight polymers, were formed together with THF-soluble polymers by the Pd-catalyzed polymerization The Pd catalyst polymerized nonpolar monomers 1 and 2 to give the polymers in yields lower than the Mo catalyst, while the Pd catalyst polymerized polar monomers 3 and 4 to give the corresponding polymers in higher yields. The 1H NMR and UV-vis absorption spectra of the polymers indicated that the cis-contents of the Pd-based polymers were higher than those of the Mo-based polymers, and the conjugation length of the Pd-based polymers was shorter than that of the Mo-based polymers. Pd-based poly(5) emitted fluorescence most strongly among poly(1)-poly(5). © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym.Chem. 2016. In the experiment, the researchers used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Safety of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Safety of 1-Bromo-2-isopropylbenzene The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The origin of a common compound about 7073-94-1

The synthetic route of 7073-94-1 has been constantly updated, and we look forward to future research findings.

Electric Literature of 7073-94-1, These common heterocyclic compound, 7073-94-1, name is 1-Bromo-2-isopropylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A sealed 10mL glass tube containing substrate 1a-1s (1.5mmol), trimethylsilylacetylene (1.5mmol), triethylamine (7.5mmol), Pd(PPh3)2Cl2 (5mol%), CuI (10mol%), and acetonitrile (1mL) was placed in the cavity of a microwave reactor and irradiated for 2-10min, at 120C and power 150W. After cooling to room temperature by an N2-flow, the tube was removed from the rotor. The reaction mixture was combined with dichloromethane (30mL) and water (30mL). The organic layer was separated and washed with water (2×30mL), dried over sodium sulfate, and concentrated. Purification by column chromatography, eluting with petroleum ether gave 1-aryl-2-(trimethylsilyl)acetylenes (2a-2s) as coloured oils or solids. All the products 2a-2s were characterized by 1H NMR and EI-MS. (See Supporting Information file for characterization data of 1H NMR and EI-MS spectrum.)

The synthetic route of 7073-94-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lei, Yonghua; Hu, Tianhan; Wu, Xingsen; Wu, Yue; Xiang, Hua; Sun, Haopeng; You, Qidong; Zhang, Xiaojin; Tetrahedron Letters; vol. 57; 10; (2016); p. 1100 – 1103;,
Bromide – Wikipedia,
bromide – Wiktionary

Analyzing the synthesis route of 7073-94-1

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 7073-94-1, A common heterocyclic compound, 7073-94-1, name is 1-Bromo-2-isopropylbenzene, molecular formula is C9H11Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of dihydroisoquinolinone 8 (2.0 mmol), aryl/heteroaryl bromide (3.0 mmol), palladium acetate (0.2 mmol) and BINAP (0.2 mmol) in dioxane (10.0 mL) was degassed with argon. Then sodium tert-butoxide (3.0 mmol) was added. The reaction mixture was heated at 100 C under argon for 1 h, and then it was cooled to room temperature, quenched with ammonium chloride, and extracted with EtOAc. The organic extract was washed with brine, dried over sodium sulfate, and concentrated in vacuo. The crude material obtained was purified by silica-gel flash column chromatography to give the desired dihydroisoquinolinone 9.

Reference:
Article; Hu, Min; Guzzo, Peter R.; Zha, Congxiang; Nacro, Kassoum; Yang, Yuh-Lin; Hassler, Carla; Liu, Shuang; Tetrahedron Letters; vol. 53; 7; (2012); p. 846 – 848;,
Bromide – Wikipedia,
bromide – Wiktionary

Share a compound : 7073-94-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-isopropylbenzene, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 7073-94-1, name is 1-Bromo-2-isopropylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7073-94-1, Product Details of 7073-94-1

To a solution of 1-bromo-2-isopropylbenzene (300 mg, 1.51 mmol) in dry THF (4.0 mL) cooled at -78 C, n-BuLi (1.6 M in n-hexane, 1.04 mL, 1.66 mmol) was added dropwise over 20 min. The mixturewas stirred for 15 min and dry DMF (128muL, 1.66 mmol) was slowly added at -78 C. After 15 minthe temperature was raised up to -10 C and water was added. The mixture was extracted 3 timeswith dichloromethane (5 mL), and the combined organic layers were dried over anhydrous Na2SO4,filtered and concentrated. The residue was purified by flash chromatography on silica gel (1:20 ethylacetate/petroleum ether), to give 10SI as a colorless oil (61% yield). 1H NMR (300 MHz, CDCl3): delta10.36 (s, 1H), 7.81 (d, 1H, J = 7.8 Hz), 7.55 (t, 1H, J = 7.5 Hz), 7.44 (d, 1H, J = 4.8 Hz), 7.34 (t, 1H, J =7.5 Hz), 4.01 – 3.95 (m, 1H), 1.32 (s, 3H), 1.25 (s, 3H).

Reference:
Article; D’Alessandro, Sarah; Alfano, Gloria; Di Cerbo, Luisa; Brogi, Simone; Chemi, Giulia; Relitti, Nicola; Brindisi, Margherita; Lamponi, Stefania; Novellino, Ettore; Campiani, Giuseppe; Gemma, Sandra; Basilico, Nicoletta; Taramelli, Donatella; Baratto, Maria Camilla; Pogni, Rebecca; Butini, Stefania; Bioorganic Chemistry; vol. 89; (2019);,
Bromide – Wikipedia,
bromide – Wiktionary

Introduction of a new synthetic route about 7073-94-1

Application of 7073-94-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7073-94-1, name is 1-Bromo-2-isopropylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A Teflon-lined autoclave (25 mL) was charged with MeONa (1.08 g, 20.0 mmol), MeOH (10 mL), CuCl (40 mg, 0.40 mmol), HCOOMe (0.25 mL, 0.97 g/mL, 4.0 mmol), and monohaloarene (10.0 mmol) then heated to 115 C, with stirring, for 2 h. After completion of the reaction, the reactor was cooled to room temperature. The mixture was stirred for 0.5 h in the open, then concentrated to recover pure MeOH. Diethyl ether (15 mL) and dilute hydrochloric acid (1.6 M, 15 mL) were added to the residue. The mixture separated into two layers, and the aqueous phase was extracted with diethyl ether (15 mL x 3). The combined organic layers were dried over anhydrous Na2SO4 and concentrated to give a residue which was purified by column chromatography on silica gel (mobile phase: petroleum ether-ethyl acetate 15:1) to furnish 1 (conversion and selectivity were determined by GC-MS analysis). The purity of the recovered MeOH was measured as more than 99 % by GC, and the water content of the recovered MeOH was measured as less than 0.12 % by use of the Karl Fischer method.

Reference:
Article; Guo, Ying; Ji, Si-Zhe; Chen, Cheng; Liu, Hong-Wei; Zhao, Jian-Hong; Zheng, Yu-Lin; Ji, Ya-Fei; Research on Chemical Intermediates; vol. 41; 11; (2015); p. 8651 – 8664;,
Bromide – Wikipedia,
bromide – Wiktionary