Category: 7073-94-1

In 2018,Rao, Xiaofeng; Li, Naikai; Bai, Heng; Dai, Chaodi; Wang, Zheng; Tang, Wenjun published 《Efficient Synthesis of (-)-Corynoline by Enantioselective Palladium-Catalyzed α-Arylation with Sterically Hindered Substrates》.Angewandte Chemie, International Edition published the findings.Recommanded Product: 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

Sterically hindered substrates can be employed in an enantioselective palladium-catalyzed α-arylation with the chiral monophosphorus ligand BI-DIME. This process enabled an efficient synthesis of the antidepressant (S)-nafenodone (I), a four-step enantioselective synthesis of the Sceletium alkaloid (+)-sceletium A-4 (II), a concise five-step enantioselective synthesis of (-)-corynoline (III), as well as a three-step preparation of (-)-DeN-corynoline (IV).1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 1-Bromo-2-isopropylbenzene) was used in this study.

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Recommanded Product: 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Guofeng; Wu, Yi; Wu, Hai-Hong; Yang, Junfeng; Zhang, Junliang published their research in Journal of the American Chemical Society in 2021. The article was titled 《Pd/GF-Phos-Catalyzed Asymmetric Three-component Coupling Reaction to Access Chiral Diarylmethyl Alkynes》.Computed Properties of C9H11Br The article contains the following contents:

Herein, a Pd-catalyzed enantioselective three-component coupling of N-tosylhydrazone, aryl halide and terminal alkyne under mild conditions utilizing a novel chiral sulfinamide phosphine ligand (GF-Phos), which provided a facile access to chiral diarylmethyl alkynes, the useful synthons in organic synthesis as well as exists as skeleton in many bioactive mols. was reported. A pair of enantiomers of the product could be easily prepared using the same chiral ligand by simply changing the aryl substituents of the N-tosylhydrazone, aryl halide. The salient features of this reaction included the readily available starting materials, general substrate scope, high enantioselectivity, ease of scale up, mild reaction conditions and versatile transformations. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Computed Properties of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Computed Properties of C9H11Br In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Kundu, Gourab; Opincal, Filip; Sperger, Theresa; Schoenebeck, Franziska published an article in Angewandte Chemie, International Edition. The title of the article was 《Air-Stable PdI Dimer Enabled Remote Functionalization: Access to Fluorinated 1,1-Diaryl Alkanes with Unprecedented Speed》.Recommanded Product: 7073-94-1 The author mentioned the following in the article:

This work features a remote arylation in less than 10 min reaction time at room temperature over a distance of up to 11 carbons. The unprecedented speed was enabled by the air-stable PdI dimer [Pd(μ-I)(PCy2t-Bu)]2, which in contrast to its PtBu3 counterpart does not trigger direct coupling at the initiation site, but regioconvergent and chemoselective remote functionalization to yield valuable fluorinated 1,1-diaryl alkanes. This study combined exptl. and computational studies rationalize the origins of switchability, which were primarily due to differences in dispersion interactions. In the experiment, the researchers used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Recommanded Product: 7073-94-1 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Nozawa-Kumada, Kanako; Ono, Kanako; Kurosu, Satoshi; Shigeno, Masanori; Kondo, Yoshinori published an article in Organic & Biomolecular Chemistry. The title of the article was 《Copper-catalyzed aerobic benzylic C(sp3)-H lactonization of 2-alkylbenzamides via N-centered radicals》.Formula: C9H11Br The author mentioned the following in the article:

Copper-catalyzed aerobic C(sp3)-H functionalization of 2-alkylbenzamides for the synthesis of benzolactones were reported. This reaction proceeded via 1,5-hydrogen atom transfer of N-centered radicals directly generated by N-H bond cleavage and did not require the synthesis of pre-functionalized N-centered radical precursors or the use of strong stoichiometric oxidants. In the experiment, the researchers used many compounds, for example, 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Formula: C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Formula: C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 1-Bromo-2-isopropylbenzeneIn 2017 ,《Ruthenium-Catalyzed Site-Selective Intramolecular Silylation of Primary C-H Bonds for Synthesis of Sila-Heterocycles》 was published in Journal of the American Chemical Society. The article was written by Fang, Huaquan; Hou, Wenjun; Liu, Guixia; Huang, Zheng. The article contains the following contents:

Incorporating the silicon element into bioactive organic mols. has received increasing attention in medicinal chem. Moreover, organosilanes are valuable synthetic intermediates for fine chems. and materials. Transition metal-catalyzed C-H silylation has become an important strategy for C-Si bond formations. However, despite the great advances in aromatic C(sp2)-H bond silylations, catalytic methods for aliphatic C(sp3)-H bond silylations are relatively rare. Here we report a pincer ruthenium catalyst for intramol. silylations of various primary C(sp3)-H bonds adjacent to heteroatoms (O, N, Si, Ge), including the first intramol. silylations of C-H bonds α to O, N, and Ge. This method provides a general, synthetically efficient approach to novel classes of Si-containing five-membered [1,3]-sila-heterocycles, including oxasilolanes, azasilolanes, disila-heterocycles, and germasilolane. The trend in the reactivity of five classes of C(sp3)-H bonds toward the Ru-catalyzed silylation is elucidated. Mechanistic studies indicate that the rate-determining step is the C-H bond cleavage involving a ruthenium silyl complex as the key intermediate, while a η2-silene ruthenium hydride species is determined to be an off-cycle intermediate. In addition to this study using 1-Bromo-2-isopropylbenzene, there are many other studies that have used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 1-Bromo-2-isopropylbenzene) was used in this study.

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 1-Bromo-2-isopropylbenzene Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Atropisomerism in diarylamines: structural requirements and mechanisms of conformational interconversion》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Costil, Romain; Sterling, Alistair J.; Duarte, Fernanda; Clayden, Jonathan. Formula: C9H11Br The article mentions the following:

In common with other hindered structures containing two aromatic rings linked by a short tether, diarylamines may exhibit atropisomerism (chirality due to restricted rotation). Previous examples have principally been tertiary amines, especially those with cyclic scaffolds. Little is known of the structural requirement for atropisomerism in structurally simpler secondary and acyclic diarylamines. In this paper we describe a systematic study of a series of acyclic secondary diarylamines, and we quantify the degree of steric hindrance in the ortho positions that is required for atropisomerism to result. Through a detailed exptl. and computational anal., the role of each ortho-substituent on the mechanism and rate of conformational interconversion is rationalized. We also present a simple predictive model for the design of configurationally stable secondary diarylamines. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Formula: C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Formula: C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Asian Journal of Organic Chemistry included an article by Nozawa-Kumada, Kanako; Kurosu, Satoshi; Shigeno, Masanori; Kondo, Yoshinori. Recommanded Product: 7073-94-1. The article was titled 《Peroxydisulfate-Mediated Transition-Metal-Free Oxidative C(sp3)-H Bond Lactonization》. The information in the text is summarized as follows:

An inexpensive, powerful and eco-friendly method for transition-metal-free oxidative C(sp3)-H bond lactonization was developed using sodium peroxydisulfate as the sole oxidant. The cyclization of 2-alkylbenzoic acids containing a primary, secondary or tertiary carbon at the benzylic position proceeded smoothly, affording a variety of lactone derivatives Furthermore, various functional groups such as halogen, cyano, nitro and hydroxy groups were tolerated under the reaction conditions. In the experimental materials used by the author, we found 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Recommanded Product: 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Pitts, Cody Ross; Ling, Bill; Snyder, Joshua A.; Bragg, Arthur E.; Lectka, Thomas published 《Aminofluorination of Cyclopropanes: A Multifold Approach through a Common, Catalytically Generated Intermediate》.Journal of the American Chemical Society published the findings.Synthetic Route of C9H11Br The information in the text is summarized as follows:

We have discovered a highly regioselective aminofluorination of cyclopropanes. Remarkably, four unique sets of conditions-two photochem., two purely chem.-generated the same aminofluorinated adducts in good to excellent yields. The multiple, diverse ways in which the reaction could be initiated provided valuable clues that led to the proposal of a “”unifying”” chain propagation mechanism beyond initiation, tied by a common intermediate. In all, the proposed mechanism herein is substantiated by product distribution studies, kinetic analyses, LFERs, Rehm-Weller estimations of ΔGET, competition experiments, KIEs, fluorescence data, and DFT calculations From a more phys. standpoint, transient-absorption experiments have allowed direct spectroscopic observation of radical ion intermediates (previously only postulated or probed indirectly in photochem. fluorination systems) and, consequently, have provided kinetic support for chain propagation. Lastly, calculations suggest that solvent may play an important role in the cyclopropane ring-opening step. The results came from multiple reactions, including the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Synthetic Route of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Synthetic Route of C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Ong, Derek Yiren; Tejo, Ciputra; Xu, Kai; Hirao, Hajime; Chiba, Shunsuke published 《Hydrodehalogenation of Haloarenes by a Sodium Hydride-Iodide Composite》.Angewandte Chemie, International Edition published the findings.Name: 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

A simple protocol for hydrodebromination and -deiodination of halo(hetero)arenes was enabled by sodium hydride (NaH) in the presence of lithium iodide (LiI). Mechanistic studies showed that an unusual concerted nucleophilic aromatic substitution operates in the present process. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Name: 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Name: 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of the American Chemical Society included an article by Garcia, Kevin J.; Gilbert, Michael M.; Weix, Daniel J.. Application In Synthesis of 1-Bromo-2-isopropylbenzene. The article was titled 《Nickel-Catalyzed Addition of Aryl Bromides to Aldehydes To Form Hindered Secondary Alcohols》. The information in the text is summarized as follows:

Transition-metal-catalyzed addition of aryl halides across carbonyls remains poorly developed, especially for aliphatic aldehydes and hindered substrate combinations. We report here that simple nickel complexes of bipyridine and PyBox can catalyze the addition of aryl halides to both aromatic and aliphatic aldehydes using zinc metal as the reducing agent. This convenient approach tolerates acidic functional groups that are not compatible with Grignard reactions, yet sterically hindered substrates still couple in high yield (33 examples, 70% average yield). Mechanistic studies show that an arylnickel, and not an arylzinc, adds efficiently to cyclohexanecarboxaldehyde, but only in the presence of a Lewis acid co-catalyst (ZnBr2). The experimental process involved the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Application In Synthesis of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 1-Bromo-2-isopropylbenzene Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary