Category: 7073-94-1

In 2017,Yoon, Dong-Oh; Zhao, Xiaodi; Son, Dohyun; Han, Jung Tae; Yun, Jaesook; Shin, Dongyun; Park, Hyun-Ju published 《SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists》.ACS Medicinal Chemistry Letters published the findings.Name: 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

G-protein coupled receptor 40 (GPR40) has been considered to be an attractive drug target for the treatment of type 2 diabetes because of its role in free fatty acids-mediated enhancement of glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. A series of indole-5-propanoic acid compounds were synthesized, and their GPR40 agonistic activities were evaluated by nuclear factor of activated T-cells reporter assay and GSIS assay in the MIN-6 insulinoma cells. Three compounds, 8h (3-(2-(2-chlorophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 58.6 nM), 8i (3-(2-(3-chlorophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 37.8 nM), and 8o (3-(2-(2-bromophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 9.4 nM), were identified as potent GPR40 agonists with good GSIS effects. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Name: 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 1-Bromo-2-isopropylbenzene Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Uzarewicz-Baig, Magdalena; Wilhelm, Rene published 《Straightforward Diastereoselective Synthesis of P-Chirogenic (1R)-1,8,8-Trimethyl-2,4-diaza-3-phosphabicyclo[3.2.1]octane 3-Oxides: Application as Chiral NMR Solvating Agents》.Heteroatom Chemistry published the findings.Application In Synthesis of 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

A direct route to enantio- and diastereopure nitrogen-substituted phosphine oxides has been developed. The desired P-stereogenic compounds were obtained in good yields and high purity. The starting point of the synthesis was (+)-camphor, which is a readily available compound from the chiral pool. The new nitrogen-substituted phosphine oxides could be transformed from their pentavalent state to their trivalent form with N,O-bis(trimethylsilyl)acetamide, which makes them potential chiral ligands. It was possible to apply these compounds as chiral-solvating agents in chiral recognition experiments with a racemic alc. and acid. In addition to this study using 1-Bromo-2-isopropylbenzene, there are many other studies that have used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Application In Synthesis of 1-Bromo-2-isopropylbenzene) was used in this study.

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application In Synthesis of 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Tria, George S.; Abrams, Tinya; Baird, Jason; Burks, Heather E.; Firestone, Brant; Gaither, L. Alex; Hamann, Lawrence G.; He, Guo; Kirby, Christina A.; Kim, Sunkyu; Lombardo, Franco; Macchi, Kaitlin J.; McDonnell, Donald P.; Mishina, Yuji; Norris, John D.; Nunez, Jill; Springer, Clayton; Sun, Yingchuan; Thomsen, Noel M.; Wang, Chunrong; Wang, Jianling; Yu, Bing; Tiong-Yip, Choi-Lai; Peukert, Stefan published 《Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer》.Journal of Medicinal Chemistry published the findings.Reference of 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

In breast cancer, estrogen receptor alpha (ERα) pos. cancer accounts for approx. 74% of all diagnoses, and in these settings, it is a primary driver of cell proliferation. Treatment of ERα pos. breast cancer has long relied on endocrine therapies such as selective estrogen receptor modulators, aromatase inhibitors, and selective estrogen receptor degraders (SERDs). The steroid-based anti-estrogen fulvestrant, the only approved SERD, is effective in patients who have not previously been treated with endocrine therapy as well as in patients who have progressed after receiving other endocrine therapies. Its efficacy, however, may be limited due to its poor physicochem. properties. THe authors describe the design and synthesis of a series of potent benzothiophene-containing compounds that exhibit oral bioavailability and preclin. activity as SERDs. This article culminates in the identification of LSZ102 (I), a compound in clin. development for the treatment of ERα pos. breast cancer. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Reference of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Reference of 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium Catalyzed C-O Coupling of Amino Alcohols for the Synthesis of Aryl Ethers》 was written by Mikus, Malte S.; Sanchez, Carina; Fridrich, Cary; Larrow, Jay F.. Application of 7073-94-1 And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

Amine containing aryl ethers are common pharmacophore motifs that continue to emerge from drug discovery efforts. As amino alcs. are readily available building blocks, practical methodologies for incorporating them into more complex structures are highly desirable. We report our efforts to explore the application of Pd-catalyzed C-O coupling methods to the arylation of 1,2- and 1,3-amino alcs. [e.g., 1-bromo-4-(trifluoromethyl)benzene + amino alc. I → II (82%, 68% isolated)]. We established general and reliable conditions, under which we explored the scope and limitations of the transformation. The insights gained have been valuable in employing this methodol. within a fast-moving drug discovery environment, which we anticipate will be of general interest to the synthesis and catalysis communities. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Application of 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Application of 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Su, Bo; Hartwig, John F. published 《Ir-Catalyzed enantioselective, intramolecular silylation of methyl C-H Bonds》.Journal of the American Chemical Society published the findings.Recommanded Product: 7073-94-1 The information in the text is summarized as follows:

2-Isopropylphenyl hydrosilanes undergo intramol. silylative asym. cyclization, catalyzed by iridium chiral oxazolinylpyridine and oxazolinylquinoline complexes, giving chiral 3-methyl-1-silaindanes with >95% enantioselectivity, the dehydrogenative coupling being promoted by addition of hydrogen acceptors, 3,3-dimethyl-1-butene or norbornene. We report highly enantioselective intramol., silylations of unactivated, primary C(sp3)-H bonds. The reactions form dihydrobenzosiloles in high yields with excellent enantioselectivities by functionalization of enantiotopic Me groups under mild conditions. The reaction is catalyzed by an iridium complex generated from [Ir(COD)OMe]2 and chiral dinitrogen ligands that we recently disclosed. The C-Si bonds in the enantioenriched dihydrobenzosiloles were further transformed to C-Cl, C-Br, C-I, and C-O bonds in final products. The potential of this reaction was illustrated by sequential C(sp3)-H and C(sp2)-H silylations and functionalizations, as well as diastereoselective C-H silylations of a chiral, natural-product derivative containing multiple types of C-H bonds. Preliminary mechanistic studies suggest that C-H cleavage is the rate-determining step. The experimental process involved the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Recommanded Product: 7073-94-1 Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Weglarz, Izabela; Michalak, Karol; Mlynarski, Jacek published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Zinc-Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2-Aryl-Substituted Pyrrolidines as Pharmaceutical Building Blocks》.Quality Control of 1-Bromo-2-isopropylbenzene The article contains the following contents:

The first successful enantioselective hydrosilylation of cyclic imines promoted by a chiral zinc complex was reported. In situ generated zinc-ProPhenol complex with silane afforded pharmaceutically relevant enantioenriched 2-aryl-substituted pyrrolidines in high yields and with excellent enantioselectivities (up to 99% ee). The synthetic utility of presented methodol. was demonstrated in an efficient synthesis of the corresponding chiral cyclic amines, being pharmaceutical drug precursors to the Aticaprant and Larotrectinib. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Quality Control of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Quality Control of 1-Bromo-2-isopropylbenzene Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Koshino, Seitaro; Taniguchi, Tohru; Monde, Kenji; Kwon, Eunsang; Hayashi, Yujiro published their research in Chemistry – A European Journal in 2021. The article was titled 《Enantiodivergent One-Pot Synthesis of Axially Chiral Biaryls Using Organocatalyst-Mediated Enantioselective Domino Reaction and Central-to-Axial Chirality Conversion》.Product Details of 7073-94-1 The article contains the following contents:

Enantiodivergent one-pot synthesis of biaryls I (Ar = 2-O2NC6H4, 2-IC6H4, 1-naphthyl, etc.; R = H, 6-Br, 7-Br) from aryl aldehydes II and cinnamaldehydes ArCH:CHCHO has been developed using a catalytic amount of a single chiral source. A domino organocatalyst-mediated enantioselective Michael reaction and aldol condensation provided centrally chiral dihydronaphthalenes with excellent enantioselectivity, from which an enantiodivergent chirality conversion from central-to-axial chirality was achieved. Both enantiomers of biaryls I were obtained with excellent enantioselectivity. All transformations can be conducted in a single reaction vessel. A plausible reaction mechanism for the enantiodivergence is proposed. The results came from multiple reactions, including the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Product Details of 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Product Details of 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Knorr, Rudolf; Lattke, Ernst; Ruhdorfer, Jakob; von Roman, Ulrich; Firl, Joachim; Boehrer, Petra published 《What can 13C and 1H NMR lithiation shifts tell us about the charge distribution in α-arylvinyllithium compounds?》.Journal of Organometallic Chemistry published the findings.Application of 7073-94-1 The information in the text is summarized as follows:

The energetically stabilizing delocalization of neg. elec. charge from the Li-C(α) bond into the aryl π system of α-arylvinyllithiums, Ar-C(Li)=CH2, is most efficient with an orthogonal relationship of the aryl ring plane and the C=C double-bond plane. This aryl conformation remains favored with at least one ortho-substituent in the α-aryl group. The lithiation NMR shifts, Δδ = δ(R-Li) – δ(R-H), of the remote, para-positioned 13C and 1H nuclei appear to be dominated by the delocalized π charge (quasi-benzyllithium), as judged through comparison of the C-para/para-H lithiation shift quotients with that of benzyllithium. The magnitudes |Δδ(C-para)| observed with two α-(2-alkylphenyl)vinyllithiums are highest for the trisolvated monomers in THF and decrease with decreasing solvation and increasing aggregation. In 3-lithio-1,1-dimethylindene, on the other hand, the α-aryl group is conformationally fixed in a coplanar relationship with the C=C double bond; this prevents a direct π charge delocalization from the Li-C(α) bond into the adjacent aryl ring with the expected result of Δδ(C-para) ≈ 0 in the absence of electron donor ligands. However, the disolvated dimer of this conformationally flattened α-arylvinyllithium exhibited a Δδ(C-para) value whose magnitude was reduced by only 51% from that of the disolvated dimer of the above α-(2-methylphenyl)vinyllithium with its orthogonal orientation. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Application of 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 7073-94-1 Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Li, Zheng; Liu, Chunxia; Xu, Xue; Qiu, Qianqian; Su, Xin; Dai, Yuxuan; Yang, Jianyong; Li, Huilan; Shi, Wei; Liao, Chen; Pan, Miaobo; Huang, Wenlong; Qian, Hai published 《Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes》.European Journal of Medicinal Chemistry published the findings.Name: 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

The free fatty acid receptor 1 (FFA1) has emerged as an attractive anti-diabetic target that mediates glucose-stimulated insulin secretion. Several FFA1 agonists have been reported, but many of them possessed somewhat high lipophilicity and/or mol. weight Herein, the authors describe the identification of sulfone-carboxylic acid moiety with the multiple advantages of reducing lipophilicity, cytotoxicity and β-oxidation associated with compound 2 (I). Further structure-activity relationship study based on the privileged scaffolds led to the discovery of 2-{(4-[(2′-chloro-[1,1′-biphenyl]-3-yl)methoxy]phenyl)sulfonyl}acetic acid (compound 20), which showed a better balance than compound 2 in terms of physicochem. properties, cytotoxicity profiles and pharmacokinetic properties. Subsequent in vivo studies demonstrated that compound 20 robustly improves the glucose tolerance both in normal and type 2 diabetic models without the risk of hypoglycemia. Compared to the high risk of TAK-875 induced liver toxicity, there was no significant adverse effects such as hepatic and renal toxicity were observed in the chronic toxicity studies of compound 20 even at the higher dose. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Name: 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Name: 1-Bromo-2-isopropylbenzene The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,European Journal of Medicinal Chemistry included an article by Li, Zheng; Liu, Chunxia; Yang, Jianyong; Zhou, Jiaqi; Ye, Zhiwen; Feng, Dazhi; Yue, Na; Tong, Jiayi; Huang, Wenlong; Qian, Hai. Reference of 1-Bromo-2-isopropylbenzene. The article was titled 《Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold》. The information in the text is summarized as follows:

Based on an old phenoxyacetic acid scaffold, CPU014 (compound 14) has been identified as a superior agonist by comprehensive exploration of structure-activity relationship. In vitro toxicity study suggested that CPU014 has lower risk of hepatotoxicity than TAK-875. During acute toxicity study (5-500 mg/kg), a favorable therapeutic window of CPU014 was observed by evaluation of plasma profiles and liver slices. Moreover, CPU014 promotes insulin secretion in a glucose-dependent manner, while no GLP-1 secretion has been enhanced. Other than good pharmacokinetic properties, CPU014 significantly improved glucose tolerance both in normal and diabetic models without the risk of hypoglycemia. These subversive findings provided a safer candidate CPU014, which is currently in preclin. study to assess its potential for the treatment of diabetes. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Reference of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Reference of 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary