Category: 7073-94-1

Product Details of 7073-94-1In 2018 ,《Silylation of Aryl Halides with Monoorganosilanes Activated by Lithium Alkoxide》 was published in Organic Letters. The article was written by Yoshida, Takumi; Ilies, Laurean; Nakamura, Eiichi. The article contains the following contents:

Li alkoxide activates a monoorganosilane to generate a transient LiH/alkoxysilane complex, which quickly reacts with aryl and alkenyl halides at 25° to deliver a diorganosilane product. Exptl. and theor. studies suggest that the reaction includes nucleophilic attack of LiH on the halogen atom of the organic halide to generate a transient organolithium/alkoxysilane intermediate, which undergoes quick C-Si bond formation within the complex. In the experimental materials used by the author, we found 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Product Details of 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of 1-Bromo-2-isopropylbenzeneIn 2016 ,《Microwave-assisted copper- and palladium-catalyzed Sonogashira-type coupling of aryl bromides and iodides with trimethylsilylacetylene》 was published in Tetrahedron Letters. The article was written by Lei, Yonghua; Hu, Tianhan; Wu, Xingsen; Wu, Yue; Xiang, Hua; Sun, Haopeng; You, Qidong; Zhang, Xiaojin. The article contains the following contents:

An efficient and rapid method was developed for the synthesis of 1-aryl-2-(trimethylsilyl)acetylene. Copper and palladium-catalyzed Sonogashira-type coupling of trimethylsilylacetylene and aryl bromides or iodides in the presence of triethylamine as base under microwave irradiation in acetonitrile afforded the desired 1-aryl-2-(trimethylsilyl)acetylene. The use of microwave was found to significantly improve the reaction yield and shorten the reaction time. In the experiment, the researchers used many compounds, for example, 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Application In Synthesis of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 1-Bromo-2-isopropylbenzene Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis, Structural Characterization, and Coordination Chemistry of (Trineopentylphosphine)palladium(aryl)bromide Dimer Complexes ([(Np3P)Pd(Ar)Br]2)》 was written by Hu, Huaiyuan; Vasiliu, Monica; Stein, Trent H.; Qu, Fengrui; Gerlach, Deidra L.; Dixon, David A.; Shaughnessy, Kevin H.. Application In Synthesis of 1-Bromo-2-isopropylbenzeneThis research focused ontrineopentylphosphine palladium aryl bromide dimer preparation crystal mol structure; cross coupling Buchwald Hartwig amination trineopentylphosphine palladium aryl bromide; binding equilibrium pyridine trineopentylphosphine palladium aryl bromide dimer. The article conveys some information:

A series of [(PNp3)Pd(Ar)Br]2 complexes (PNp3 = trineopentylphosphine, Ar = 4-tolyl, 4-tert-butylphenyl, 2-tolyl, 4-methoxy-2-methylphenyl, 2-isopropylphenyl, and 2,6-dimethylphenyl) were synthesized and structurally characterized by x-ray crystallog. and d. functional theory optimized structures. The trineopentylphosphine ligand is able to accommodate coordination of other sterically demanding ligands through changes in its conformation. These conformational changes can be seen in changes in percent buried volume of the PNp3 ligand. The binding equilibrium of the [(PNp3)Pd(Ar)Br]2 complexes with pyridine derivatives were determined exptl. and analyzed computationally. The binding equilibrium are sensitive to the steric demand of the pyridine ligand and less sensitive to the steric demand of the aryl ligand on palladium. In contrast to previous studies, the binding equilibrium do not correlate with pyridine basicity. The binding equilibrium results are relevant to fundamental ligand coordination steps in cross-coupling reactions, such as Buchwald-Hartwig aminations. X-ray crystal structures of [(PNp3)Pd(Ar)Br]2 (PNp3 = trineopentylphosphine) are reported and compared to DFT-optimized geometries. The PNp3 ligand is highly flexible, allowing coordination of hindered aryl ligands. Binding equilibrium with pyridine depend primarily on the steric demand of the pyridine and the aryl ligand, whereas pyridine basicity is not a major factor. In the experiment, the researchers used many compounds, for example, 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Application In Synthesis of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Application In Synthesis of 1-Bromo-2-isopropylbenzene Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Gildner, Peter G.; DeAngelis, Andrew; Colacot, Thomas J. published 《Palladium-Catalyzed N-Arylation of Cyclopropylamines》.Organic Letters published the findings.Computed Properties of C9H11Br The information in the text is summarized as follows:

A general method has been developed for the previously challenging arylation of cyclopropylamine and N-arylcyclopropylamines. Highly active, air-stable, and com. available R-allylpalladium precatalysts provide access to a wide range of (hetero)arylated cyclopropylanilines in high yields. Precatalysts [(tBuBrettPhos)Pd(allyl)]OTf and [(BrettPhos)Pd(crotyl)]OTf deliver monoarylated products, while (PtBu3)Pd(crotyl)Cl is suited for preparing unsym. diarylated products. The developed conditions tolerate a range of functional groups and heterocycles, allowing access to an array of arylated cyclopropylamines, a motif present in prominent drug mols.1-Bromo-2-isopropylbenzene(cas: 7073-94-1Computed Properties of C9H11Br) was used in this study.

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Computed Properties of C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Nature Communications included an article by He, Zhi-Tao; Hartwig, John F.. SDS of cas: 7073-94-1. The article was titled 《Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds》. The information in the text is summarized as follows:

A generally applicable approach to attach small rings to a wide range of aromatic compounds by palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters was reported. The direct α-arylation of cyclopropyl esters and cyclobutyl esters was achieved in high yield by ensuring that rate of coupling exceeded rate of Claisen condensation. The α-arylation of azetidines was achieved without ring opening of strained saturated heterocycle by conducting reactions with an azetidine derivative bearing a benzyl protecting group on nitrogen. Mechanistic studies showed that α-arylation of small rings was challenging because of the weak acidity of α C-H bond (cyclopropanes), strong sensitivity of strained esters to Claisen condensation (cyclobutatanes), or facile decomposition of enolates (azetidinyl esters). In the experiment, the researchers used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1SDS of cas: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. SDS of cas: 7073-94-1 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Konishi, Hideyuki; Fujita, Ririka; Yamaguchi, Miyuki; Manabe, Kei published an article in Organic Letters. The title of the article was 《Synthesis of Symmetrical Sulfides Enabled by a Sulfur Dioxide Surrogate Acting as a Divalent Sulfur Source》.Electric Literature of C9H11Br The author mentioned the following in the article:

A safe and practical methodol. for synthesizing sym. sulfides using iodoarenes and potassium metabisulfite (K2S2O5) was presented. While K2S2O5 was known as a convenient sulfur dioxide surrogate, here it acted as a divalent sulfur source, pioneering its potential utility. The reaction exhibited wide substrate generality in which even highly bulky substrates can be applied to afford sterically congested sulfides. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Electric Literature of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Electric Literature of C9H11Br The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Paradiso, Veronica; Bertolasi, Valerio; Costabile, Chiara; Caruso, Tonino; Dabrowski, Michal; Grela, Karol; Grisi, Fabia published 《Expanding the Family of Hoveyda-Grubbs Catalysts Containing Unsymmetrical NHC Ligands》.Organometallics published the findings.Electric Literature of C9H11Br The information in the text is summarized as follows:

Hoveyda-Grubbs 2nd-generation catalysts containing N-alkyl/N’-aryl N-heterocyclic carbene (NHC) ligands were synthesized and studied in representative olefin metathesis reactions. Steric perturbations of unsym. NHCs were achieved through modulation of the hindrance of alkyl (neopentyl, neophyl, cyclohexyl) and aryl (2-isopropylphenyl, mesityl) substituents at the N atoms in combination with different backbone configurations (syn and anti). The NHC substitution patterns strongly influence the stability and reactivity of the corresponding complexes. In general, complexes bearing an anti NHC backbone are more stable and more active than their corresponding syn isomers. In both the series, the presence of bulky, highly branched N-alkyl groups tends to give reduced catalytic differences between syn and anti isomers, whereas the nature of the N’-aryl substituent (2-isopropylphenyl or mesityl) gives rise to different activity and/or selectivity. Of note, an N’-mesityl catalyst with anti backbone is highly competent in the ethenolysis of Et oleate, achieving up to 90% selectivity for the formation of terminal olefins. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Electric Literature of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Electric Literature of C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Haichao; Lau, Vincent Ho Man; Xu, Pan; Chan, Tsz Hin; Huang, Zhongxing published an article in Nature Communications. The title of the article was 《Diverse synthesis of α-tertiary amines and tertiary alcohols via desymmetric reduction of malonic esters》.Electric Literature of C9H11Br The author mentioned the following in the article:

While conventional methods towards these motifs often rely on enantioselective carbon-carbon or carbon-heteroatom bond formation reactions, a desym. method was developed here by selectively hydrosilylating one of the esters of easily accessible α-substituted α-amino- and -oxymalonic esters. The desymmetrization was enabled by a suite of dinuclear zinc catalysts with pipecolinol-derived tetradentate ligands and could accommodate a diverse panel of heteroatom substituents, including secondary amides, tertiary amines and ethers of different sizes. The polyfunctionalized reduction products, in return, had provided expeditious approaches to enantioenriched nitrogen- and oxygen-containing mols., including dipeptides, vitamin analogs, and natural metabolites. The experimental process involved the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Electric Literature of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Electric Literature of C9H11Br The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 7073-94-1In 2018 ,《Au-Catalyzed Oxidative Arylation: Chelation-Induced Turnover of ortho-Substituted Arylsilanes》 was published in ACS Catalysis. The article was written by Robinson, Matthew P.; Lloyd-Jones, Guy C.. The article contains the following contents:

Ortho-Substituted aryl silanes have previously been found to undergo much slower Au-catalyzed intermol. arylation than their m,p-substituted isomers, with many examples failing to undergo turnover at all. A method to indirectly quantify the rates of C-Si auration of o-substituted aryl silanes, under conditions of turnover, has been developed. All examples are found to undergo very efficient C-Si auration, indicative that it is the subsequent C-H auration that is inhibited by the ortho substituent. A simple Ar-Au conformational model suggests that C-H auration can be accelerated by chelation. A series of ortho-functionalized aryl silanes are shown to undergo efficient arylation. In the experimental materials used by the author, we found 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Recommanded Product: 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《”Bulky-Yet-Flexible” α-Diimine Palladium-Catalyzed Reductive Heck Cross-Coupling: Highly Anti-Markovnikov-Selective Hydroarylation of Alkene in Air》 was published in Journal of Organic Chemistry in 2020. These research results belong to Yang, Xu-Wen; Li, Dong-Hui; Song, A-Xiang; Liu, Feng-Shou. Synthetic Route of C9H11Br The article mentions the following:

To pursue a highly regioselective and efficient reductive Heck reaction, a series of moisture- and air-stable α-diimine palladium precatalysts was rationally designed, readily synthesized, and fully characterized. The relationship between the structures of the palladium complexes and the catalytic properties was investigated. It was revealed that the “”bulky-yet-flexible”” palladium complexes allowed highly anti-Markovnikov-selective hydroarylation of alkenes with (hetero)aryl bromides under aerobic conditions. Further, synthetic application of the present protocol could provide rapid and straightforward access to functional and biol. active mols. In the experiment, the researchers used many compounds, for example, 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Synthetic Route of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Synthetic Route of C9H11Br Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary