Category: 707-34-6

Application of 707-34-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 707-34-6 name is 1,3,5-Tribromoadamantane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step seven, equipped with a condenser, a thermometer four 5L reaction flask were successively added 473g1.3.5- tribromo adamantane, 946 g silver sulfate, 946 g of water and 94.6ml of toluene, stirring was started, 946 g of concentrated sulfuric acid was added dropwise, complete after the temperature was raised to about 110 deg.] C under reflux for 16 hours. (2 in the control) document.write(“”); Step 8 After completion of the reaction, the temperature was lowered to room temperature, filtered, the filter cake was washed with 700ml of water and the combined filtrate, the filtrate was added 250g sodium bromide was stirred for half an hour excess silver ions precipitate was filtered, the filter cake was washed with 300ml of water, combined filtrate. The filtrate was diluted with 500ml of water was added.document.write(“”); Step 9 using 30% sodium hydroxide solution PH = 12-13, at a temperature controlled above 75 , use up to about 2850 g of liquid caustic soda, After completion, it was cooled to 25-30 & deg.] C slowly, stirred for 30min, filtered, and collected by filtration cake. document.write(“”); Step 10, the filter cake was added to 1.8L of methanol, 57g of activated carbon, stirred for IH, filtered, and the filtrate was recovered white paste, into 1.5L petroleum ether was filtered to give the product as a white solid 210g. (3 in the control)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3,5-Tribromoadamantane, and friends who are interested can also refer to it.

Reference:
Patent; XuzhouBokang Information Chemicals co., LTD; FU, ZHIWEI; (9 pag.)CN104628526; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 707-34-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 707-34-6, name is 1,3,5-Tribromoadamantane, This compound has unique chemical properties. The synthetic route is as follows.

A 250 ml three-necked flask equipped with a condenser was charged with 3.7 g (10 mmol) of 1,3,5-tribromoadamantane, 16.0 g of 1,3-dibromo-2-methoxybenzene (60.0 mmol) and30 ml of 1,2-dichloroethane,Condenser duct from the upper end connected to an inverted funnel 30% NaOH aqueous solution,To absorb the HBr produced by the reaction.At 0 ice water bath,1.0 g (ie, 4.0 mmol) of AlBr3 was added to the reaction system,Continue stirring in the ice water bath for half an hour,Then gradually returned to room temperature,The reaction system was heated in an oil bath to 60 C for 5 hours,The reaction solution was cooled to room temperature,Pour into 100 mL of acidic ice water and stir for 1 h.After the ice has completely melted, 100 ml of methylene chloride is added to the mixture for extraction. The organic layer is washed with water until neutral, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and the filtrate is concentrated. The mixture is then recrystallized from a mixed solution of ethyl acetate and methanol ,6.58 g of a white solid was obtained in a yield of 71%.

The chemical industry reduces the impact on the environment during synthesis 1,3,5-Tribromoadamantane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Chen Jinping; Li Yi; Yu Tianjun; Zeng Yi; (18 pag.)CN107266319; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 707-34-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 707-34-6, name is 1,3,5-Tribromoadamantane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE I Synthesis of 1,3,5-Triethynyladamantane Vinyl bromide (60 mL) was added, dropwise, over 1.5 h to a solution of 1,3,5-tribromoadamantane (43 g, 115 mmol) and aluminum chloride (10 g) in CH2 Cl2 (100 mL) at a rate such that the internal temperature did not exceed -20 C. The progress of reaction, as indicated by the disappearance of 1,3,5-tribromoadamantane, was monitored by GLC and 1 H NMR. The reaction mixture was stirred at -20 C. for 1.5 hours, diluted with dichloromethane and poured slowly over crushed ice and concentrated hydrochloric acid (40 mL). The organic layer was separated and the aqueous layer was extracted with dichloromethane. The combined organic layers were washed with water, dried (MgSO4) and filtered and solvent was evaporated under reduced pressure to give 80 g of crude 1,3,5-tris(2,2-dibromoethyl)adamantane. The crude material was dissolved in DMSO (350 mL) and potassium t-butoxide (80 g, 714 mmol) was added portion-wise over a period of 20 minutes. The mixture was stirred at ambient temperature for 48 h, diluted with dichloromethane and poured over crushed ice/water/concentrated hydrochloric acid (5 mL). The organic layer was separated and the aqueous layer was extracted with dichloromethane. The combined organic layers were washed with water and brine, dired (MgSO4), filtered and stripped of solvent under reduced pressure to give an oil. This oil was distilled under reduced pressure (120-130 C./0.5 mm) to give 14,6 g (61%) of 1,3,5-triethynyladamantane. An analytical sample was recrystallized from pentane: mp. 84-86 C; IR 3350 and 2150 cm-1; 1 H NMR delta 2.13 (s, 3 H, C CH) and 1,96 (s, 6 H) and 1.79 (m, 7 H); Anal. Calcd for C16 H16; C, 92.26; H, 7.74. Found: C, 92.10; H, 7.79.

The synthetic route of 1,3,5-Tribromoadamantane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Baum; Kurt; Archibald; Thomas G.; Malik; Aslam A.; US5017734; (1991); A;,
Bromide – Wikipedia,
bromide – Wiktionary